1. SARS-CoV-2-associated gut microbiome alteration; A new contributor to colorectal cancer pathogenesis.
- Author
-
Mozaffari SA, Salehi A, Mousavi E, Zaman BA, Nassaj AE, Ebrahimzadeh F, Nasiri H, Valedkarimi Z, Adili A, Asemani G, and Akbari M
- Subjects
- Humans, SARS-CoV-2, Dysbiosis, Gastrointestinal Microbiome genetics, COVID-19, Colorectal Neoplasms
- Abstract
The emergence of a novel coronavirus, COVID-19, in December 2019 led to a global pandemic with more than 170 million confirmed infections and more than 6 million deaths (by July 2022). Studies have shown that infection with SARS-CoV-2 in cancer patients has a higher mortality rate than in people without cancer. Here, we have reviewed the evidence showing that gut microbiota plays an important role in health and is linked to colorectal cancer development. Studies have shown that SARS-CoV-2 infection leads to a change in gut microbiota, which modify intestinal inflammation and barrier permeability and affects tumor-suppressor or oncogene genes, proposing SARS-CoV-2 as a potential contributor to CRC pathogenesis., Competing Interests: Competing interests The authors declare that they have no competing interests., (Copyright © 2022 Elsevier GmbH. All rights reserved.)
- Published
- 2022
- Full Text
- View/download PDF