1. T cell Large Granular Lymphocytic Leukemia with Pulmonary Hypertension.
- Author
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Khalid S, Daw H, Jacob M, and Nakashima M
- Subjects
- Adult, Humans, Hypertension, Pulmonary complications, Hypertension, Pulmonary immunology, Leukemia, Large Granular Lymphocytic complications, Leukemia, Large Granular Lymphocytic immunology, Male, Prognosis, T-Lymphocytes, Cytotoxic immunology, Hypertension, Pulmonary pathology, Leukemia, Large Granular Lymphocytic pathology, T-Lymphocytes, Cytotoxic pathology
- Abstract
T cell large granular lymphocytic leukemia is a hematological disorder which is characterized by the proliferation of CD 3+ cytotoxic T cells. We present a case about a patient who was diagnosed with T cell large granular lymphocytic leukemia and then developed pulmonary hypertension. He was treated for his leukemia with methotrexate and simultaneously treated for his pulmonary hypertension with selexipag and ambrisentan. As his leukemia improved, we also noticed an improvement in his pulmonary hypertension from a NYHA class IV to class I. Hence, we believe there is an etiopathological link between the T cell large granular leukemia and associated pulmonary hypertension.
- Published
- 2018