Author: "Ragettli, Martina S." / Publisher: graduate school of public health, seoul national university, seoul, south korea - Searchworks@Jio Institute Digital Library Search Results

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24 results on '"Ragettli, Martina S."'

1. Comparison for the effects of different components of temperature variability on mortality : A multi-country time-series study

Author: Wen, Bo, Wu, Yao, Guo, Yuming, Gasparrini, Antonio, Tong, Shilu, Overcenco, Ala, Urban, Aleš, Schneider, Alexandra, Entezari, Alireza, Vicedo-Cabrera, Ana Maria, Zanobetti, Antonella, Analitis, Antonis, Zeka, Ariana, Tobias, Aurelio, Nunes, Baltazar, Alahmad, Barrak, Armstrong, Ben, Forsberg, Bertil, Pan, Shih-Chun, Íñiguez, Carmen, Ameling, Caroline, Valencia, César De la Cruz, Åström, Christofer, Houthuijs, Danny, Van Dung, Do, Royé, Dominic, Indermitte, Ene, Lavigne, Eric, Mayvaneh, Fatemeh, Acquaotta, Fiorella, de'Donato, Francesca, Rao, Shilpa, Sera, Francesco, Carrasco-Escobar, Gabriel, Kan, Haidong, Orru, Hans, Kim, Ho, Holobaca, Iulian-Horia, Kyselý, Jan, Madureira, Joana, Schwartz, Joel, Jaakkola, Jouni J.K., Katsouyanni, Klea, Diaz, Magali Hurtado, Ragettli, Martina S., Hashizume, Masahiro, Pascal, Mathilde, Coélho, Micheline de Sousa Zanotti Stagliorio, Ortega, Nicolás Valdés, Ryti, Niilo, Scovronick, Noah, Michelozzi, Paola, Matus Correa, Patricia, Goodman, Patrick, Saldiva, Paulo Hilario Nascimento, Raz, Raanan, Abrutzky, Rosana, Osorio, Samuel, Dang, Tran Ngoc, Colistro, Valentina, Huber, Veronika, Lee, Whanhee, Seposo, Xerxes, Honda, Yasushi, Kim, Yoonhee, Guo, Yue Leon, Bell, Michelle L., Li, Shanshan, Wen, Bo, Wu, Yao, Guo, Yuming, Gasparrini, Antonio, Tong, Shilu, Overcenco, Ala, Urban, Aleš, Schneider, Alexandra, Entezari, Alireza, Vicedo-Cabrera, Ana Maria, Zanobetti, Antonella, Analitis, Antonis, Zeka, Ariana, Tobias, Aurelio, Nunes, Baltazar, Alahmad, Barrak, Armstrong, Ben, Forsberg, Bertil, Pan, Shih-Chun, Íñiguez, Carmen, Ameling, Caroline, Valencia, César De la Cruz, Åström, Christofer, Houthuijs, Danny, Van Dung, Do, Royé, Dominic, Indermitte, Ene, Lavigne, Eric, Mayvaneh, Fatemeh, Acquaotta, Fiorella, de'Donato, Francesca, Rao, Shilpa, Sera, Francesco, Carrasco-Escobar, Gabriel, Kan, Haidong, Orru, Hans, Kim, Ho, Holobaca, Iulian-Horia, Kyselý, Jan, Madureira, Joana, Schwartz, Joel, Jaakkola, Jouni J.K., Katsouyanni, Klea, Diaz, Magali Hurtado, Ragettli, Martina S., Hashizume, Masahiro, Pascal, Mathilde, Coélho, Micheline de Sousa Zanotti Stagliorio, Ortega, Nicolás Valdés, Ryti, Niilo, Scovronick, Noah, Michelozzi, Paola, Matus Correa, Patricia, Goodman, Patrick, Saldiva, Paulo Hilario Nascimento, Raz, Raanan, Abrutzky, Rosana, Osorio, Samuel, Dang, Tran Ngoc, Colistro, Valentina, Huber, Veronika, Lee, Whanhee, Seposo, Xerxes, Honda, Yasushi, Kim, Yoonhee, Guo, Yue Leon, Bell, Michelle L., and Li, Shanshan
Abstract: Background: Temperature variability (TV) is associated with increased mortality risk. However, it is still unknown whether intra-day or inter-day TV has different effects. Objectives: We aimed to assess the association of intra-day TV and inter-day TV with all-cause, cardiovascular, and respiratory mortality. Methods: We collected data on total, cardiovascular, and respiratory mortality and meteorology from 758 locations in 47 countries or regions from 1972 to 2020. We defined inter-day TV as the standard deviation (SD) of daily mean temperatures across the lag interval, and intra-day TV as the average SD of minimum and maximum temperatures on each day. In the first stage, inter-day and intra-day TVs were modelled simultaneously in the quasi-Poisson time-series model for each location. In the second stage, a multi-level analysis was used to pool the location-specific estimates. Results: Overall, the mortality risk due to each interquartile range [IQR] increase was higher for intra-day TV than for inter-day TV. The risk increased by 0.59% (95% confidence interval [CI]: 0.53, 0.65) for all-cause mortality, 0.64% (95% CI: 0.56, 0.73) for cardiovascular mortality, and 0.65% (95% CI: 0.49, 0.80) for respiratory mortality per IQR increase in intra-day TV0–7 (0.9 °C). An IQR increase in inter-day TV0–7 (1.6 °C) was associated with 0.22% (95% CI: 0.18, 0.26) increase in all-cause mortality, 0.44% (95% CI: 0.37, 0.50) increase in cardiovascular mortality, and 0.31% (95% CI: 0.21, 0.41) increase in respiratory mortality. The proportion of all-cause deaths attributable to intra-day TV0–7 and inter-day TV0–7 was 1.45% and 0.35%, respectively. The mortality risks varied by lag interval, climate area, season, and climate type. Conclusions: Our results indicated that intra-day TV may explain the main part of the mortality risk related to TV and suggested that comprehensive evaluations should be proposed in more countries to help protect human health.
Published: 2024
Full Text: View/download PDF

2. Comparison for the effects of different components of temperature variability on mortality : A multi-country time-series study

Author: Wen, Bo, Wu, Yao, Guo, Yuming, Gasparrini, Antonio, Tong, Shilu, Overcenco, Ala, Urban, Aleš, Schneider, Alexandra, Entezari, Alireza, Vicedo-Cabrera, Ana Maria, Zanobetti, Antonella, Analitis, Antonis, Zeka, Ariana, Tobias, Aurelio, Nunes, Baltazar, Alahmad, Barrak, Armstrong, Ben, Forsberg, Bertil, Pan, Shih-Chun, Íñiguez, Carmen, Ameling, Caroline, Valencia, César De la Cruz, Åström, Christofer, Houthuijs, Danny, Van Dung, Do, Royé, Dominic, Indermitte, Ene, Lavigne, Eric, Mayvaneh, Fatemeh, Acquaotta, Fiorella, de'Donato, Francesca, Rao, Shilpa, Sera, Francesco, Carrasco-Escobar, Gabriel, Kan, Haidong, Orru, Hans, Kim, Ho, Holobaca, Iulian-Horia, Kyselý, Jan, Madureira, Joana, Schwartz, Joel, Jaakkola, Jouni J.K., Katsouyanni, Klea, Diaz, Magali Hurtado, Ragettli, Martina S., Hashizume, Masahiro, Pascal, Mathilde, Coélho, Micheline de Sousa Zanotti Stagliorio, Ortega, Nicolás Valdés, Ryti, Niilo, Scovronick, Noah, Michelozzi, Paola, Matus Correa, Patricia, Goodman, Patrick, Saldiva, Paulo Hilario Nascimento, Raz, Raanan, Abrutzky, Rosana, Osorio, Samuel, Dang, Tran Ngoc, Colistro, Valentina, Huber, Veronika, Lee, Whanhee, Seposo, Xerxes, Honda, Yasushi, Kim, Yoonhee, Guo, Yue Leon, Bell, Michelle L., Li, Shanshan, Wen, Bo, Wu, Yao, Guo, Yuming, Gasparrini, Antonio, Tong, Shilu, Overcenco, Ala, Urban, Aleš, Schneider, Alexandra, Entezari, Alireza, Vicedo-Cabrera, Ana Maria, Zanobetti, Antonella, Analitis, Antonis, Zeka, Ariana, Tobias, Aurelio, Nunes, Baltazar, Alahmad, Barrak, Armstrong, Ben, Forsberg, Bertil, Pan, Shih-Chun, Íñiguez, Carmen, Ameling, Caroline, Valencia, César De la Cruz, Åström, Christofer, Houthuijs, Danny, Van Dung, Do, Royé, Dominic, Indermitte, Ene, Lavigne, Eric, Mayvaneh, Fatemeh, Acquaotta, Fiorella, de'Donato, Francesca, Rao, Shilpa, Sera, Francesco, Carrasco-Escobar, Gabriel, Kan, Haidong, Orru, Hans, Kim, Ho, Holobaca, Iulian-Horia, Kyselý, Jan, Madureira, Joana, Schwartz, Joel, Jaakkola, Jouni J.K., Katsouyanni, Klea, Diaz, Magali Hurtado, Ragettli, Martina S., Hashizume, Masahiro, Pascal, Mathilde, Coélho, Micheline de Sousa Zanotti Stagliorio, Ortega, Nicolás Valdés, Ryti, Niilo, Scovronick, Noah, Michelozzi, Paola, Matus Correa, Patricia, Goodman, Patrick, Saldiva, Paulo Hilario Nascimento, Raz, Raanan, Abrutzky, Rosana, Osorio, Samuel, Dang, Tran Ngoc, Colistro, Valentina, Huber, Veronika, Lee, Whanhee, Seposo, Xerxes, Honda, Yasushi, Kim, Yoonhee, Guo, Yue Leon, Bell, Michelle L., and Li, Shanshan
Abstract: Background: Temperature variability (TV) is associated with increased mortality risk. However, it is still unknown whether intra-day or inter-day TV has different effects. Objectives: We aimed to assess the association of intra-day TV and inter-day TV with all-cause, cardiovascular, and respiratory mortality. Methods: We collected data on total, cardiovascular, and respiratory mortality and meteorology from 758 locations in 47 countries or regions from 1972 to 2020. We defined inter-day TV as the standard deviation (SD) of daily mean temperatures across the lag interval, and intra-day TV as the average SD of minimum and maximum temperatures on each day. In the first stage, inter-day and intra-day TVs were modelled simultaneously in the quasi-Poisson time-series model for each location. In the second stage, a multi-level analysis was used to pool the location-specific estimates. Results: Overall, the mortality risk due to each interquartile range [IQR] increase was higher for intra-day TV than for inter-day TV. The risk increased by 0.59% (95% confidence interval [CI]: 0.53, 0.65) for all-cause mortality, 0.64% (95% CI: 0.56, 0.73) for cardiovascular mortality, and 0.65% (95% CI: 0.49, 0.80) for respiratory mortality per IQR increase in intra-day TV0–7 (0.9 °C). An IQR increase in inter-day TV0–7 (1.6 °C) was associated with 0.22% (95% CI: 0.18, 0.26) increase in all-cause mortality, 0.44% (95% CI: 0.37, 0.50) increase in cardiovascular mortality, and 0.31% (95% CI: 0.21, 0.41) increase in respiratory mortality. The proportion of all-cause deaths attributable to intra-day TV0–7 and inter-day TV0–7 was 1.45% and 0.35%, respectively. The mortality risks varied by lag interval, climate area, season, and climate type. Conclusions: Our results indicated that intra-day TV may explain the main part of the mortality risk related to TV and suggested that comprehensive evaluations should be proposed in more countries to help protect human health.
Published: 2024
Full Text: View/download PDF

3. Comparison for the effects of different components of temperature variability on mortality : A multi-country time-series study

Author: Wen, Bo, Wu, Yao, Guo, Yuming, Gasparrini, Antonio, Tong, Shilu, Overcenco, Ala, Urban, Aleš, Schneider, Alexandra, Entezari, Alireza, Vicedo-Cabrera, Ana Maria, Zanobetti, Antonella, Analitis, Antonis, Zeka, Ariana, Tobias, Aurelio, Nunes, Baltazar, Alahmad, Barrak, Armstrong, Ben, Forsberg, Bertil, Pan, Shih-Chun, Íñiguez, Carmen, Ameling, Caroline, Valencia, César De la Cruz, Åström, Christofer, Houthuijs, Danny, Van Dung, Do, Royé, Dominic, Indermitte, Ene, Lavigne, Eric, Mayvaneh, Fatemeh, Acquaotta, Fiorella, de'Donato, Francesca, Rao, Shilpa, Sera, Francesco, Carrasco-Escobar, Gabriel, Kan, Haidong, Orru, Hans, Kim, Ho, Holobaca, Iulian-Horia, Kyselý, Jan, Madureira, Joana, Schwartz, Joel, Jaakkola, Jouni J.K., Katsouyanni, Klea, Diaz, Magali Hurtado, Ragettli, Martina S., Hashizume, Masahiro, Pascal, Mathilde, Coélho, Micheline de Sousa Zanotti Stagliorio, Ortega, Nicolás Valdés, Ryti, Niilo, Scovronick, Noah, Michelozzi, Paola, Matus Correa, Patricia, Goodman, Patrick, Saldiva, Paulo Hilario Nascimento, Raz, Raanan, Abrutzky, Rosana, Osorio, Samuel, Dang, Tran Ngoc, Colistro, Valentina, Huber, Veronika, Lee, Whanhee, Seposo, Xerxes, Honda, Yasushi, Kim, Yoonhee, Guo, Yue Leon, Bell, Michelle L., Li, Shanshan, Wen, Bo, Wu, Yao, Guo, Yuming, Gasparrini, Antonio, Tong, Shilu, Overcenco, Ala, Urban, Aleš, Schneider, Alexandra, Entezari, Alireza, Vicedo-Cabrera, Ana Maria, Zanobetti, Antonella, Analitis, Antonis, Zeka, Ariana, Tobias, Aurelio, Nunes, Baltazar, Alahmad, Barrak, Armstrong, Ben, Forsberg, Bertil, Pan, Shih-Chun, Íñiguez, Carmen, Ameling, Caroline, Valencia, César De la Cruz, Åström, Christofer, Houthuijs, Danny, Van Dung, Do, Royé, Dominic, Indermitte, Ene, Lavigne, Eric, Mayvaneh, Fatemeh, Acquaotta, Fiorella, de'Donato, Francesca, Rao, Shilpa, Sera, Francesco, Carrasco-Escobar, Gabriel, Kan, Haidong, Orru, Hans, Kim, Ho, Holobaca, Iulian-Horia, Kyselý, Jan, Madureira, Joana, Schwartz, Joel, Jaakkola, Jouni J.K., Katsouyanni, Klea, Diaz, Magali Hurtado, Ragettli, Martina S., Hashizume, Masahiro, Pascal, Mathilde, Coélho, Micheline de Sousa Zanotti Stagliorio, Ortega, Nicolás Valdés, Ryti, Niilo, Scovronick, Noah, Michelozzi, Paola, Matus Correa, Patricia, Goodman, Patrick, Saldiva, Paulo Hilario Nascimento, Raz, Raanan, Abrutzky, Rosana, Osorio, Samuel, Dang, Tran Ngoc, Colistro, Valentina, Huber, Veronika, Lee, Whanhee, Seposo, Xerxes, Honda, Yasushi, Kim, Yoonhee, Guo, Yue Leon, Bell, Michelle L., and Li, Shanshan
Abstract: Background: Temperature variability (TV) is associated with increased mortality risk. However, it is still unknown whether intra-day or inter-day TV has different effects. Objectives: We aimed to assess the association of intra-day TV and inter-day TV with all-cause, cardiovascular, and respiratory mortality. Methods: We collected data on total, cardiovascular, and respiratory mortality and meteorology from 758 locations in 47 countries or regions from 1972 to 2020. We defined inter-day TV as the standard deviation (SD) of daily mean temperatures across the lag interval, and intra-day TV as the average SD of minimum and maximum temperatures on each day. In the first stage, inter-day and intra-day TVs were modelled simultaneously in the quasi-Poisson time-series model for each location. In the second stage, a multi-level analysis was used to pool the location-specific estimates. Results: Overall, the mortality risk due to each interquartile range [IQR] increase was higher for intra-day TV than for inter-day TV. The risk increased by 0.59% (95% confidence interval [CI]: 0.53, 0.65) for all-cause mortality, 0.64% (95% CI: 0.56, 0.73) for cardiovascular mortality, and 0.65% (95% CI: 0.49, 0.80) for respiratory mortality per IQR increase in intra-day TV0–7 (0.9 °C). An IQR increase in inter-day TV0–7 (1.6 °C) was associated with 0.22% (95% CI: 0.18, 0.26) increase in all-cause mortality, 0.44% (95% CI: 0.37, 0.50) increase in cardiovascular mortality, and 0.31% (95% CI: 0.21, 0.41) increase in respiratory mortality. The proportion of all-cause deaths attributable to intra-day TV0–7 and inter-day TV0–7 was 1.45% and 0.35%, respectively. The mortality risks varied by lag interval, climate area, season, and climate type. Conclusions: Our results indicated that intra-day TV may explain the main part of the mortality risk related to TV and suggested that comprehensive evaluations should be proposed in more countries to help protect human health.
Published: 2024
Full Text: View/download PDF

4. Comparison for the effects of different components of temperature variability on mortality : A multi-country time-series study

Author: Wen, Bo, Wu, Yao, Guo, Yuming, Gasparrini, Antonio, Tong, Shilu, Overcenco, Ala, Urban, Aleš, Schneider, Alexandra, Entezari, Alireza, Vicedo-Cabrera, Ana Maria, Zanobetti, Antonella, Analitis, Antonis, Zeka, Ariana, Tobias, Aurelio, Nunes, Baltazar, Alahmad, Barrak, Armstrong, Ben, Forsberg, Bertil, Pan, Shih-Chun, Íñiguez, Carmen, Ameling, Caroline, Valencia, César De la Cruz, Åström, Christofer, Houthuijs, Danny, Van Dung, Do, Royé, Dominic, Indermitte, Ene, Lavigne, Eric, Mayvaneh, Fatemeh, Acquaotta, Fiorella, de'Donato, Francesca, Rao, Shilpa, Sera, Francesco, Carrasco-Escobar, Gabriel, Kan, Haidong, Orru, Hans, Kim, Ho, Holobaca, Iulian-Horia, Kyselý, Jan, Madureira, Joana, Schwartz, Joel, Jaakkola, Jouni J.K., Katsouyanni, Klea, Diaz, Magali Hurtado, Ragettli, Martina S., Hashizume, Masahiro, Pascal, Mathilde, Coélho, Micheline de Sousa Zanotti Stagliorio, Ortega, Nicolás Valdés, Ryti, Niilo, Scovronick, Noah, Michelozzi, Paola, Matus Correa, Patricia, Goodman, Patrick, Saldiva, Paulo Hilario Nascimento, Raz, Raanan, Abrutzky, Rosana, Osorio, Samuel, Dang, Tran Ngoc, Colistro, Valentina, Huber, Veronika, Lee, Whanhee, Seposo, Xerxes, Honda, Yasushi, Kim, Yoonhee, Guo, Yue Leon, Bell, Michelle L., Li, Shanshan, Wen, Bo, Wu, Yao, Guo, Yuming, Gasparrini, Antonio, Tong, Shilu, Overcenco, Ala, Urban, Aleš, Schneider, Alexandra, Entezari, Alireza, Vicedo-Cabrera, Ana Maria, Zanobetti, Antonella, Analitis, Antonis, Zeka, Ariana, Tobias, Aurelio, Nunes, Baltazar, Alahmad, Barrak, Armstrong, Ben, Forsberg, Bertil, Pan, Shih-Chun, Íñiguez, Carmen, Ameling, Caroline, Valencia, César De la Cruz, Åström, Christofer, Houthuijs, Danny, Van Dung, Do, Royé, Dominic, Indermitte, Ene, Lavigne, Eric, Mayvaneh, Fatemeh, Acquaotta, Fiorella, de'Donato, Francesca, Rao, Shilpa, Sera, Francesco, Carrasco-Escobar, Gabriel, Kan, Haidong, Orru, Hans, Kim, Ho, Holobaca, Iulian-Horia, Kyselý, Jan, Madureira, Joana, Schwartz, Joel, Jaakkola, Jouni J.K., Katsouyanni, Klea, Diaz, Magali Hurtado, Ragettli, Martina S., Hashizume, Masahiro, Pascal, Mathilde, Coélho, Micheline de Sousa Zanotti Stagliorio, Ortega, Nicolás Valdés, Ryti, Niilo, Scovronick, Noah, Michelozzi, Paola, Matus Correa, Patricia, Goodman, Patrick, Saldiva, Paulo Hilario Nascimento, Raz, Raanan, Abrutzky, Rosana, Osorio, Samuel, Dang, Tran Ngoc, Colistro, Valentina, Huber, Veronika, Lee, Whanhee, Seposo, Xerxes, Honda, Yasushi, Kim, Yoonhee, Guo, Yue Leon, Bell, Michelle L., and Li, Shanshan
Abstract: Background: Temperature variability (TV) is associated with increased mortality risk. However, it is still unknown whether intra-day or inter-day TV has different effects. Objectives: We aimed to assess the association of intra-day TV and inter-day TV with all-cause, cardiovascular, and respiratory mortality. Methods: We collected data on total, cardiovascular, and respiratory mortality and meteorology from 758 locations in 47 countries or regions from 1972 to 2020. We defined inter-day TV as the standard deviation (SD) of daily mean temperatures across the lag interval, and intra-day TV as the average SD of minimum and maximum temperatures on each day. In the first stage, inter-day and intra-day TVs were modelled simultaneously in the quasi-Poisson time-series model for each location. In the second stage, a multi-level analysis was used to pool the location-specific estimates. Results: Overall, the mortality risk due to each interquartile range [IQR] increase was higher for intra-day TV than for inter-day TV. The risk increased by 0.59% (95% confidence interval [CI]: 0.53, 0.65) for all-cause mortality, 0.64% (95% CI: 0.56, 0.73) for cardiovascular mortality, and 0.65% (95% CI: 0.49, 0.80) for respiratory mortality per IQR increase in intra-day TV0–7 (0.9 °C). An IQR increase in inter-day TV0–7 (1.6 °C) was associated with 0.22% (95% CI: 0.18, 0.26) increase in all-cause mortality, 0.44% (95% CI: 0.37, 0.50) increase in cardiovascular mortality, and 0.31% (95% CI: 0.21, 0.41) increase in respiratory mortality. The proportion of all-cause deaths attributable to intra-day TV0–7 and inter-day TV0–7 was 1.45% and 0.35%, respectively. The mortality risks varied by lag interval, climate area, season, and climate type. Conclusions: Our results indicated that intra-day TV may explain the main part of the mortality risk related to TV and suggested that comprehensive evaluations should be proposed in more countries to help protect human health.
Published: 2024
Full Text: View/download PDF

5. Heat-related cardiorespiratory mortality : effect modification by air pollution across 482 cities from 24 countries

Author: Rai, Masna, Stafoggia, Massimo, de'Donato, Francesca, Scortichini, Matteo, Zafeiratou, Sofia, Vazquez Fernandez, Liliana, Zhang, Siqi, Katsouyanni, Klea, Samoli, Evangelia, Rao, Shilpa, Lavigne, Eric, Guo, Yuming, Kan, Haidong, Osorio, Samuel, Kyselý, Jan, Urban, Aleš, Orru, Hans, Maasikmets, Marek, Jaakkola, Jouni J.K., Ryti, Niilo, Pascal, Mathilde, Hashizume, Masahiro, Fook Sheng Ng, Chris, Alahmad, Barrak, Hurtado Diaz, Magali, De la Cruz Valencia, César, Nunes, Baltazar, Madureira, Joana, Scovronick, Noah, Garland, Rebecca M., Kim, Ho, Lee, Whanhee, Tobias, Aurelio, Íñiguez, Carmen, Forsberg, Bertil, Åström, Christofer, Maria Vicedo-Cabrera, Ana, Ragettli, Martina S., Leon Guo, Yue-Liang, Pan, Shih-Chun, Li, Shanshan, Gasparrini, Antonio, Sera, Francesco, Masselot, Pierre, Schwartz, Joel, Zanobetti, Antonella, Bell, Michelle L., Schneider, Alexandra, Breitner, Susanne, Rai, Masna, Stafoggia, Massimo, de'Donato, Francesca, Scortichini, Matteo, Zafeiratou, Sofia, Vazquez Fernandez, Liliana, Zhang, Siqi, Katsouyanni, Klea, Samoli, Evangelia, Rao, Shilpa, Lavigne, Eric, Guo, Yuming, Kan, Haidong, Osorio, Samuel, Kyselý, Jan, Urban, Aleš, Orru, Hans, Maasikmets, Marek, Jaakkola, Jouni J.K., Ryti, Niilo, Pascal, Mathilde, Hashizume, Masahiro, Fook Sheng Ng, Chris, Alahmad, Barrak, Hurtado Diaz, Magali, De la Cruz Valencia, César, Nunes, Baltazar, Madureira, Joana, Scovronick, Noah, Garland, Rebecca M., Kim, Ho, Lee, Whanhee, Tobias, Aurelio, Íñiguez, Carmen, Forsberg, Bertil, Åström, Christofer, Maria Vicedo-Cabrera, Ana, Ragettli, Martina S., Leon Guo, Yue-Liang, Pan, Shih-Chun, Li, Shanshan, Gasparrini, Antonio, Sera, Francesco, Masselot, Pierre, Schwartz, Joel, Zanobetti, Antonella, Bell, Michelle L., Schneider, Alexandra, and Breitner, Susanne
Abstract: Background: Evidence on the potential interactive effects of heat and ambient air pollution on cause-specific mortality is inconclusive and limited to selected locations. Objectives: We investigated the effects of heat on cardiovascular and respiratory mortality and its modification by air pollution during summer months (six consecutive hottest months) in 482 locations across 24 countries. Methods: Location-specific daily death counts and exposure data (e.g., particulate matter with diameters ≤ 2.5 µm [PM2.5]) were obtained from 2000 to 2018. We used location-specific confounder-adjusted Quasi-Poisson regression with a tensor product between air temperature and the air pollutant. We extracted heat effects at low, medium, and high levels of pollutants, defined as the 5th, 50th, and 95th percentile of the location-specific pollutant concentrations. Country-specific and overall estimates were derived using a random-effects multilevel meta-analytical model. Results: Heat was associated with increased cardiorespiratory mortality. Moreover, the heat effects were modified by elevated levels of all air pollutants in most locations, with stronger effects for respiratory than cardiovascular mortality. For example, the percent increase in respiratory mortality per increase in the 2-day average summer temperature from the 75th to the 99th percentile was 7.7% (95% Confidence Interval [CI] 7.6–7.7), 11.3% (95%CI 11.2–11.3), and 14.3% (95% CI 14.1–14.5) at low, medium, and high levels of PM2.5, respectively. Similarly, cardiovascular mortality increased by 1.6 (95%CI 1.5–1.6), 5.1 (95%CI 5.1–5.2), and 8.7 (95%CI 8.7–8.8) at low, medium, and high levels of O3, respectively. Discussion: We observed considerable modification of the heat effects on cardiovascular and respiratory mortality by elevated levels of air pollutants. Therefore, mitigation measures following the new WHO Air Quality Guidelines are crucial to enhance better health and promote sustainable development.
Published: 2023
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6. Heat-related cardiorespiratory mortality : effect modification by air pollution across 482 cities from 24 countries

Author: Rai, Masna, Stafoggia, Massimo, de'Donato, Francesca, Scortichini, Matteo, Zafeiratou, Sofia, Vazquez Fernandez, Liliana, Zhang, Siqi, Katsouyanni, Klea, Samoli, Evangelia, Rao, Shilpa, Lavigne, Eric, Guo, Yuming, Kan, Haidong, Osorio, Samuel, Kyselý, Jan, Urban, Aleš, Orru, Hans, Maasikmets, Marek, Jaakkola, Jouni J.K., Ryti, Niilo, Pascal, Mathilde, Hashizume, Masahiro, Fook Sheng Ng, Chris, Alahmad, Barrak, Hurtado Diaz, Magali, De la Cruz Valencia, César, Nunes, Baltazar, Madureira, Joana, Scovronick, Noah, Garland, Rebecca M., Kim, Ho, Lee, Whanhee, Tobias, Aurelio, Íñiguez, Carmen, Forsberg, Bertil, Åström, Christofer, Maria Vicedo-Cabrera, Ana, Ragettli, Martina S., Leon Guo, Yue-Liang, Pan, Shih-Chun, Li, Shanshan, Gasparrini, Antonio, Sera, Francesco, Masselot, Pierre, Schwartz, Joel, Zanobetti, Antonella, Bell, Michelle L., Schneider, Alexandra, Breitner, Susanne, Rai, Masna, Stafoggia, Massimo, de'Donato, Francesca, Scortichini, Matteo, Zafeiratou, Sofia, Vazquez Fernandez, Liliana, Zhang, Siqi, Katsouyanni, Klea, Samoli, Evangelia, Rao, Shilpa, Lavigne, Eric, Guo, Yuming, Kan, Haidong, Osorio, Samuel, Kyselý, Jan, Urban, Aleš, Orru, Hans, Maasikmets, Marek, Jaakkola, Jouni J.K., Ryti, Niilo, Pascal, Mathilde, Hashizume, Masahiro, Fook Sheng Ng, Chris, Alahmad, Barrak, Hurtado Diaz, Magali, De la Cruz Valencia, César, Nunes, Baltazar, Madureira, Joana, Scovronick, Noah, Garland, Rebecca M., Kim, Ho, Lee, Whanhee, Tobias, Aurelio, Íñiguez, Carmen, Forsberg, Bertil, Åström, Christofer, Maria Vicedo-Cabrera, Ana, Ragettli, Martina S., Leon Guo, Yue-Liang, Pan, Shih-Chun, Li, Shanshan, Gasparrini, Antonio, Sera, Francesco, Masselot, Pierre, Schwartz, Joel, Zanobetti, Antonella, Bell, Michelle L., Schneider, Alexandra, and Breitner, Susanne
Abstract: Background: Evidence on the potential interactive effects of heat and ambient air pollution on cause-specific mortality is inconclusive and limited to selected locations. Objectives: We investigated the effects of heat on cardiovascular and respiratory mortality and its modification by air pollution during summer months (six consecutive hottest months) in 482 locations across 24 countries. Methods: Location-specific daily death counts and exposure data (e.g., particulate matter with diameters ≤ 2.5 µm [PM2.5]) were obtained from 2000 to 2018. We used location-specific confounder-adjusted Quasi-Poisson regression with a tensor product between air temperature and the air pollutant. We extracted heat effects at low, medium, and high levels of pollutants, defined as the 5th, 50th, and 95th percentile of the location-specific pollutant concentrations. Country-specific and overall estimates were derived using a random-effects multilevel meta-analytical model. Results: Heat was associated with increased cardiorespiratory mortality. Moreover, the heat effects were modified by elevated levels of all air pollutants in most locations, with stronger effects for respiratory than cardiovascular mortality. For example, the percent increase in respiratory mortality per increase in the 2-day average summer temperature from the 75th to the 99th percentile was 7.7% (95% Confidence Interval [CI] 7.6–7.7), 11.3% (95%CI 11.2–11.3), and 14.3% (95% CI 14.1–14.5) at low, medium, and high levels of PM2.5, respectively. Similarly, cardiovascular mortality increased by 1.6 (95%CI 1.5–1.6), 5.1 (95%CI 5.1–5.2), and 8.7 (95%CI 8.7–8.8) at low, medium, and high levels of O3, respectively. Discussion: We observed considerable modification of the heat effects on cardiovascular and respiratory mortality by elevated levels of air pollutants. Therefore, mitigation measures following the new WHO Air Quality Guidelines are crucial to enhance better health and promote sustainable development.
Published: 2023
Full Text: View/download PDF

7. Heat-related cardiorespiratory mortality : effect modification by air pollution across 482 cities from 24 countries

Author: Rai, Masna, Stafoggia, Massimo, de'Donato, Francesca, Scortichini, Matteo, Zafeiratou, Sofia, Vazquez Fernandez, Liliana, Zhang, Siqi, Katsouyanni, Klea, Samoli, Evangelia, Rao, Shilpa, Lavigne, Eric, Guo, Yuming, Kan, Haidong, Osorio, Samuel, Kyselý, Jan, Urban, Aleš, Orru, Hans, Maasikmets, Marek, Jaakkola, Jouni J.K., Ryti, Niilo, Pascal, Mathilde, Hashizume, Masahiro, Fook Sheng Ng, Chris, Alahmad, Barrak, Hurtado Diaz, Magali, De la Cruz Valencia, César, Nunes, Baltazar, Madureira, Joana, Scovronick, Noah, Garland, Rebecca M., Kim, Ho, Lee, Whanhee, Tobias, Aurelio, Íñiguez, Carmen, Forsberg, Bertil, Åström, Christofer, Maria Vicedo-Cabrera, Ana, Ragettli, Martina S., Leon Guo, Yue-Liang, Pan, Shih-Chun, Li, Shanshan, Gasparrini, Antonio, Sera, Francesco, Masselot, Pierre, Schwartz, Joel, Zanobetti, Antonella, Bell, Michelle L., Schneider, Alexandra, Breitner, Susanne, Rai, Masna, Stafoggia, Massimo, de'Donato, Francesca, Scortichini, Matteo, Zafeiratou, Sofia, Vazquez Fernandez, Liliana, Zhang, Siqi, Katsouyanni, Klea, Samoli, Evangelia, Rao, Shilpa, Lavigne, Eric, Guo, Yuming, Kan, Haidong, Osorio, Samuel, Kyselý, Jan, Urban, Aleš, Orru, Hans, Maasikmets, Marek, Jaakkola, Jouni J.K., Ryti, Niilo, Pascal, Mathilde, Hashizume, Masahiro, Fook Sheng Ng, Chris, Alahmad, Barrak, Hurtado Diaz, Magali, De la Cruz Valencia, César, Nunes, Baltazar, Madureira, Joana, Scovronick, Noah, Garland, Rebecca M., Kim, Ho, Lee, Whanhee, Tobias, Aurelio, Íñiguez, Carmen, Forsberg, Bertil, Åström, Christofer, Maria Vicedo-Cabrera, Ana, Ragettli, Martina S., Leon Guo, Yue-Liang, Pan, Shih-Chun, Li, Shanshan, Gasparrini, Antonio, Sera, Francesco, Masselot, Pierre, Schwartz, Joel, Zanobetti, Antonella, Bell, Michelle L., Schneider, Alexandra, and Breitner, Susanne
Abstract: Background: Evidence on the potential interactive effects of heat and ambient air pollution on cause-specific mortality is inconclusive and limited to selected locations. Objectives: We investigated the effects of heat on cardiovascular and respiratory mortality and its modification by air pollution during summer months (six consecutive hottest months) in 482 locations across 24 countries. Methods: Location-specific daily death counts and exposure data (e.g., particulate matter with diameters ≤ 2.5 µm [PM2.5]) were obtained from 2000 to 2018. We used location-specific confounder-adjusted Quasi-Poisson regression with a tensor product between air temperature and the air pollutant. We extracted heat effects at low, medium, and high levels of pollutants, defined as the 5th, 50th, and 95th percentile of the location-specific pollutant concentrations. Country-specific and overall estimates were derived using a random-effects multilevel meta-analytical model. Results: Heat was associated with increased cardiorespiratory mortality. Moreover, the heat effects were modified by elevated levels of all air pollutants in most locations, with stronger effects for respiratory than cardiovascular mortality. For example, the percent increase in respiratory mortality per increase in the 2-day average summer temperature from the 75th to the 99th percentile was 7.7% (95% Confidence Interval [CI] 7.6–7.7), 11.3% (95%CI 11.2–11.3), and 14.3% (95% CI 14.1–14.5) at low, medium, and high levels of PM2.5, respectively. Similarly, cardiovascular mortality increased by 1.6 (95%CI 1.5–1.6), 5.1 (95%CI 5.1–5.2), and 8.7 (95%CI 8.7–8.8) at low, medium, and high levels of O3, respectively. Discussion: We observed considerable modification of the heat effects on cardiovascular and respiratory mortality by elevated levels of air pollutants. Therefore, mitigation measures following the new WHO Air Quality Guidelines are crucial to enhance better health and promote sustainable development.
Published: 2023
Full Text: View/download PDF

8. Heat-related cardiorespiratory mortality : effect modification by air pollution across 482 cities from 24 countries

Author: Rai, Masna, Stafoggia, Massimo, de'Donato, Francesca, Scortichini, Matteo, Zafeiratou, Sofia, Vazquez Fernandez, Liliana, Zhang, Siqi, Katsouyanni, Klea, Samoli, Evangelia, Rao, Shilpa, Lavigne, Eric, Guo, Yuming, Kan, Haidong, Osorio, Samuel, Kyselý, Jan, Urban, Aleš, Orru, Hans, Maasikmets, Marek, Jaakkola, Jouni J.K., Ryti, Niilo, Pascal, Mathilde, Hashizume, Masahiro, Fook Sheng Ng, Chris, Alahmad, Barrak, Hurtado Diaz, Magali, De la Cruz Valencia, César, Nunes, Baltazar, Madureira, Joana, Scovronick, Noah, Garland, Rebecca M., Kim, Ho, Lee, Whanhee, Tobias, Aurelio, Íñiguez, Carmen, Forsberg, Bertil, Åström, Christofer, Maria Vicedo-Cabrera, Ana, Ragettli, Martina S., Leon Guo, Yue-Liang, Pan, Shih-Chun, Li, Shanshan, Gasparrini, Antonio, Sera, Francesco, Masselot, Pierre, Schwartz, Joel, Zanobetti, Antonella, Bell, Michelle L., Schneider, Alexandra, Breitner, Susanne, Rai, Masna, Stafoggia, Massimo, de'Donato, Francesca, Scortichini, Matteo, Zafeiratou, Sofia, Vazquez Fernandez, Liliana, Zhang, Siqi, Katsouyanni, Klea, Samoli, Evangelia, Rao, Shilpa, Lavigne, Eric, Guo, Yuming, Kan, Haidong, Osorio, Samuel, Kyselý, Jan, Urban, Aleš, Orru, Hans, Maasikmets, Marek, Jaakkola, Jouni J.K., Ryti, Niilo, Pascal, Mathilde, Hashizume, Masahiro, Fook Sheng Ng, Chris, Alahmad, Barrak, Hurtado Diaz, Magali, De la Cruz Valencia, César, Nunes, Baltazar, Madureira, Joana, Scovronick, Noah, Garland, Rebecca M., Kim, Ho, Lee, Whanhee, Tobias, Aurelio, Íñiguez, Carmen, Forsberg, Bertil, Åström, Christofer, Maria Vicedo-Cabrera, Ana, Ragettli, Martina S., Leon Guo, Yue-Liang, Pan, Shih-Chun, Li, Shanshan, Gasparrini, Antonio, Sera, Francesco, Masselot, Pierre, Schwartz, Joel, Zanobetti, Antonella, Bell, Michelle L., Schneider, Alexandra, and Breitner, Susanne
Abstract: Background: Evidence on the potential interactive effects of heat and ambient air pollution on cause-specific mortality is inconclusive and limited to selected locations. Objectives: We investigated the effects of heat on cardiovascular and respiratory mortality and its modification by air pollution during summer months (six consecutive hottest months) in 482 locations across 24 countries. Methods: Location-specific daily death counts and exposure data (e.g., particulate matter with diameters ≤ 2.5 µm [PM2.5]) were obtained from 2000 to 2018. We used location-specific confounder-adjusted Quasi-Poisson regression with a tensor product between air temperature and the air pollutant. We extracted heat effects at low, medium, and high levels of pollutants, defined as the 5th, 50th, and 95th percentile of the location-specific pollutant concentrations. Country-specific and overall estimates were derived using a random-effects multilevel meta-analytical model. Results: Heat was associated with increased cardiorespiratory mortality. Moreover, the heat effects were modified by elevated levels of all air pollutants in most locations, with stronger effects for respiratory than cardiovascular mortality. For example, the percent increase in respiratory mortality per increase in the 2-day average summer temperature from the 75th to the 99th percentile was 7.7% (95% Confidence Interval [CI] 7.6–7.7), 11.3% (95%CI 11.2–11.3), and 14.3% (95% CI 14.1–14.5) at low, medium, and high levels of PM2.5, respectively. Similarly, cardiovascular mortality increased by 1.6 (95%CI 1.5–1.6), 5.1 (95%CI 5.1–5.2), and 8.7 (95%CI 8.7–8.8) at low, medium, and high levels of O3, respectively. Discussion: We observed considerable modification of the heat effects on cardiovascular and respiratory mortality by elevated levels of air pollutants. Therefore, mitigation measures following the new WHO Air Quality Guidelines are crucial to enhance better health and promote sustainable development.
Published: 2023
Full Text: View/download PDF

9. Heat-related cardiorespiratory mortality : effect modification by air pollution across 482 cities from 24 countries

Author: Rai, Masna, Stafoggia, Massimo, de'Donato, Francesca, Scortichini, Matteo, Zafeiratou, Sofia, Vazquez Fernandez, Liliana, Zhang, Siqi, Katsouyanni, Klea, Samoli, Evangelia, Rao, Shilpa, Lavigne, Eric, Guo, Yuming, Kan, Haidong, Osorio, Samuel, Kyselý, Jan, Urban, Aleš, Orru, Hans, Maasikmets, Marek, Jaakkola, Jouni J.K., Ryti, Niilo, Pascal, Mathilde, Hashizume, Masahiro, Fook Sheng Ng, Chris, Alahmad, Barrak, Hurtado Diaz, Magali, De la Cruz Valencia, César, Nunes, Baltazar, Madureira, Joana, Scovronick, Noah, Garland, Rebecca M., Kim, Ho, Lee, Whanhee, Tobias, Aurelio, Íñiguez, Carmen, Forsberg, Bertil, Åström, Christofer, Maria Vicedo-Cabrera, Ana, Ragettli, Martina S., Leon Guo, Yue-Liang, Pan, Shih-Chun, Li, Shanshan, Gasparrini, Antonio, Sera, Francesco, Masselot, Pierre, Schwartz, Joel, Zanobetti, Antonella, Bell, Michelle L., Schneider, Alexandra, Breitner, Susanne, Rai, Masna, Stafoggia, Massimo, de'Donato, Francesca, Scortichini, Matteo, Zafeiratou, Sofia, Vazquez Fernandez, Liliana, Zhang, Siqi, Katsouyanni, Klea, Samoli, Evangelia, Rao, Shilpa, Lavigne, Eric, Guo, Yuming, Kan, Haidong, Osorio, Samuel, Kyselý, Jan, Urban, Aleš, Orru, Hans, Maasikmets, Marek, Jaakkola, Jouni J.K., Ryti, Niilo, Pascal, Mathilde, Hashizume, Masahiro, Fook Sheng Ng, Chris, Alahmad, Barrak, Hurtado Diaz, Magali, De la Cruz Valencia, César, Nunes, Baltazar, Madureira, Joana, Scovronick, Noah, Garland, Rebecca M., Kim, Ho, Lee, Whanhee, Tobias, Aurelio, Íñiguez, Carmen, Forsberg, Bertil, Åström, Christofer, Maria Vicedo-Cabrera, Ana, Ragettli, Martina S., Leon Guo, Yue-Liang, Pan, Shih-Chun, Li, Shanshan, Gasparrini, Antonio, Sera, Francesco, Masselot, Pierre, Schwartz, Joel, Zanobetti, Antonella, Bell, Michelle L., Schneider, Alexandra, and Breitner, Susanne
Abstract: Background: Evidence on the potential interactive effects of heat and ambient air pollution on cause-specific mortality is inconclusive and limited to selected locations. Objectives: We investigated the effects of heat on cardiovascular and respiratory mortality and its modification by air pollution during summer months (six consecutive hottest months) in 482 locations across 24 countries. Methods: Location-specific daily death counts and exposure data (e.g., particulate matter with diameters ≤ 2.5 µm [PM2.5]) were obtained from 2000 to 2018. We used location-specific confounder-adjusted Quasi-Poisson regression with a tensor product between air temperature and the air pollutant. We extracted heat effects at low, medium, and high levels of pollutants, defined as the 5th, 50th, and 95th percentile of the location-specific pollutant concentrations. Country-specific and overall estimates were derived using a random-effects multilevel meta-analytical model. Results: Heat was associated with increased cardiorespiratory mortality. Moreover, the heat effects were modified by elevated levels of all air pollutants in most locations, with stronger effects for respiratory than cardiovascular mortality. For example, the percent increase in respiratory mortality per increase in the 2-day average summer temperature from the 75th to the 99th percentile was 7.7% (95% Confidence Interval [CI] 7.6–7.7), 11.3% (95%CI 11.2–11.3), and 14.3% (95% CI 14.1–14.5) at low, medium, and high levels of PM2.5, respectively. Similarly, cardiovascular mortality increased by 1.6 (95%CI 1.5–1.6), 5.1 (95%CI 5.1–5.2), and 8.7 (95%CI 8.7–8.8) at low, medium, and high levels of O3, respectively. Discussion: We observed considerable modification of the heat effects on cardiovascular and respiratory mortality by elevated levels of air pollutants. Therefore, mitigation measures following the new WHO Air Quality Guidelines are crucial to enhance better health and promote sustainable development.
Published: 2023
Full Text: View/download PDF

10. Global, regional, and national burden of mortality associated with short-term temperature variability from 2000–19 : a three-stage modelling study

Author: Wu, Yao, Li, Shanshan, Zhao, Qi, Wen, Bo, Gasparrini, Antonio, Tong, Shilu, Overcenco, Ala, Urban, Aleš, Schneider, Alexandra, Entezari, Alireza, Vicedo-Cabrera, Ana Maria, Zanobetti, Antonella, Analitis, Antonis, Zeka, Ariana, Tobias, Aurelio, Nunes, Baltazar, Alahmad, Barrak, Armstrong, Ben, Forsberg, Bertil, Pan, Shih-Chun, Íñiguez, Carmen, Ameling, Caroline, De la Cruz Valencia, César, Åström, Christofer, Houthuijs, Danny, Van Dung, Do, Royé, Dominic, Indermitte, Ene, Lavigne, Eric, Mayvaneh, Fatemeh, Acquaotta, Fiorella, de'Donato, Francesca, Rao, Shilpa, Sera, Francesco, Carrasco-Escobar, Gabriel, Kan, Haidong, Orru, Hans, Kim, Ho, Holobaca, Iulian-Horia, Kyselý, Jan, Madureira, Joana, Schwartz, Joel, Jaakkola, Jouni J K, Katsouyanni, Klea, Hurtado Diaz, Magali, Ragettli, Martina S, Hashizume, Masahiro, Pascal, Mathilde, de Sousa Zanotti Stagliorio Coélho, Micheline, Ortega, Nicolás Valdés, Ryti, Niilo, Scovronick, Noah, Michelozzi, Paola, Correa, Patricia Matus, Goodman, Patrick, Nascimento Saldiva, Paulo Hilario, Abrutzky, Rosana, Osorio, Samuel, Dang, Tran Ngoc, Colistro, Valentina, Huber, Veronika, Lee, Whanhee, Seposo, Xerxes, Honda, Yasushi, Guo, Yue Leon, Bell, Michelle L, Guo, Yuming, Wu, Yao, Li, Shanshan, Zhao, Qi, Wen, Bo, Gasparrini, Antonio, Tong, Shilu, Overcenco, Ala, Urban, Aleš, Schneider, Alexandra, Entezari, Alireza, Vicedo-Cabrera, Ana Maria, Zanobetti, Antonella, Analitis, Antonis, Zeka, Ariana, Tobias, Aurelio, Nunes, Baltazar, Alahmad, Barrak, Armstrong, Ben, Forsberg, Bertil, Pan, Shih-Chun, Íñiguez, Carmen, Ameling, Caroline, De la Cruz Valencia, César, Åström, Christofer, Houthuijs, Danny, Van Dung, Do, Royé, Dominic, Indermitte, Ene, Lavigne, Eric, Mayvaneh, Fatemeh, Acquaotta, Fiorella, de'Donato, Francesca, Rao, Shilpa, Sera, Francesco, Carrasco-Escobar, Gabriel, Kan, Haidong, Orru, Hans, Kim, Ho, Holobaca, Iulian-Horia, Kyselý, Jan, Madureira, Joana, Schwartz, Joel, Jaakkola, Jouni J K, Katsouyanni, Klea, Hurtado Diaz, Magali, Ragettli, Martina S, Hashizume, Masahiro, Pascal, Mathilde, de Sousa Zanotti Stagliorio Coélho, Micheline, Ortega, Nicolás Valdés, Ryti, Niilo, Scovronick, Noah, Michelozzi, Paola, Correa, Patricia Matus, Goodman, Patrick, Nascimento Saldiva, Paulo Hilario, Abrutzky, Rosana, Osorio, Samuel, Dang, Tran Ngoc, Colistro, Valentina, Huber, Veronika, Lee, Whanhee, Seposo, Xerxes, Honda, Yasushi, Guo, Yue Leon, Bell, Michelle L, and Guo, Yuming
Abstract: Background: Increased mortality risk is associated with short-term temperature variability. However, to our knowledge, there has been no comprehensive assessment of the temperature variability-related mortality burden worldwide. In this study, using data from the MCC Collaborative Research Network, we first explored the association between temperature variability and mortality across 43 countries or regions. Then, to provide a more comprehensive picture of the global burden of mortality associated with temperature variability, global gridded temperature data with a resolution of 0·5° × 0·5° were used to assess the temperature variability-related mortality burden at the global, regional, and national levels. Furthermore, temporal trends in temperature variability-related mortality burden were also explored from 2000–19. Methods: In this modelling study, we applied a three-stage meta-analytical approach to assess the global temperature variability-related mortality burden at a spatial resolution of 0·5° × 0·5° from 2000–19. Temperature variability was calculated as the SD of the average of the same and previous days’ minimum and maximum temperatures. We first obtained location-specific temperature variability related-mortality associations based on a daily time series of 750 locations from the Multi-country Multi-city Collaborative Research Network. We subsequently constructed a multivariable meta-regression model with five predictors to estimate grid-specific temperature variability related-mortality associations across the globe. Finally, percentage excess in mortality and excess mortality rate were calculated to quantify the temperature variability-related mortality burden and to further explore its temporal trend over two decades. Findings: An increasing trend in temperature variability was identified at the global level from 2000 to 2019. Globally, 1 753 392 deaths (95% CI 1 159 901–2 357 718) were associated with temperature variability per year, accounting for
Published: 2022
Full Text: View/download PDF

11. Global, regional, and national burden of mortality associated with short-term temperature variability from 2000–19 : a three-stage modelling study

Author: Wu, Yao, Li, Shanshan, Zhao, Qi, Wen, Bo, Gasparrini, Antonio, Tong, Shilu, Overcenco, Ala, Urban, Aleš, Schneider, Alexandra, Entezari, Alireza, Vicedo-Cabrera, Ana Maria, Zanobetti, Antonella, Analitis, Antonis, Zeka, Ariana, Tobias, Aurelio, Nunes, Baltazar, Alahmad, Barrak, Armstrong, Ben, Forsberg, Bertil, Pan, Shih-Chun, Íñiguez, Carmen, Ameling, Caroline, De la Cruz Valencia, César, Åström, Christofer, Houthuijs, Danny, Van Dung, Do, Royé, Dominic, Indermitte, Ene, Lavigne, Eric, Mayvaneh, Fatemeh, Acquaotta, Fiorella, de'Donato, Francesca, Rao, Shilpa, Sera, Francesco, Carrasco-Escobar, Gabriel, Kan, Haidong, Orru, Hans, Kim, Ho, Holobaca, Iulian-Horia, Kyselý, Jan, Madureira, Joana, Schwartz, Joel, Jaakkola, Jouni J K, Katsouyanni, Klea, Hurtado Diaz, Magali, Ragettli, Martina S, Hashizume, Masahiro, Pascal, Mathilde, de Sousa Zanotti Stagliorio Coélho, Micheline, Ortega, Nicolás Valdés, Ryti, Niilo, Scovronick, Noah, Michelozzi, Paola, Correa, Patricia Matus, Goodman, Patrick, Nascimento Saldiva, Paulo Hilario, Abrutzky, Rosana, Osorio, Samuel, Dang, Tran Ngoc, Colistro, Valentina, Huber, Veronika, Lee, Whanhee, Seposo, Xerxes, Honda, Yasushi, Guo, Yue Leon, Bell, Michelle L, Guo, Yuming, Wu, Yao, Li, Shanshan, Zhao, Qi, Wen, Bo, Gasparrini, Antonio, Tong, Shilu, Overcenco, Ala, Urban, Aleš, Schneider, Alexandra, Entezari, Alireza, Vicedo-Cabrera, Ana Maria, Zanobetti, Antonella, Analitis, Antonis, Zeka, Ariana, Tobias, Aurelio, Nunes, Baltazar, Alahmad, Barrak, Armstrong, Ben, Forsberg, Bertil, Pan, Shih-Chun, Íñiguez, Carmen, Ameling, Caroline, De la Cruz Valencia, César, Åström, Christofer, Houthuijs, Danny, Van Dung, Do, Royé, Dominic, Indermitte, Ene, Lavigne, Eric, Mayvaneh, Fatemeh, Acquaotta, Fiorella, de'Donato, Francesca, Rao, Shilpa, Sera, Francesco, Carrasco-Escobar, Gabriel, Kan, Haidong, Orru, Hans, Kim, Ho, Holobaca, Iulian-Horia, Kyselý, Jan, Madureira, Joana, Schwartz, Joel, Jaakkola, Jouni J K, Katsouyanni, Klea, Hurtado Diaz, Magali, Ragettli, Martina S, Hashizume, Masahiro, Pascal, Mathilde, de Sousa Zanotti Stagliorio Coélho, Micheline, Ortega, Nicolás Valdés, Ryti, Niilo, Scovronick, Noah, Michelozzi, Paola, Correa, Patricia Matus, Goodman, Patrick, Nascimento Saldiva, Paulo Hilario, Abrutzky, Rosana, Osorio, Samuel, Dang, Tran Ngoc, Colistro, Valentina, Huber, Veronika, Lee, Whanhee, Seposo, Xerxes, Honda, Yasushi, Guo, Yue Leon, Bell, Michelle L, and Guo, Yuming
Abstract: Background: Increased mortality risk is associated with short-term temperature variability. However, to our knowledge, there has been no comprehensive assessment of the temperature variability-related mortality burden worldwide. In this study, using data from the MCC Collaborative Research Network, we first explored the association between temperature variability and mortality across 43 countries or regions. Then, to provide a more comprehensive picture of the global burden of mortality associated with temperature variability, global gridded temperature data with a resolution of 0·5° × 0·5° were used to assess the temperature variability-related mortality burden at the global, regional, and national levels. Furthermore, temporal trends in temperature variability-related mortality burden were also explored from 2000–19. Methods: In this modelling study, we applied a three-stage meta-analytical approach to assess the global temperature variability-related mortality burden at a spatial resolution of 0·5° × 0·5° from 2000–19. Temperature variability was calculated as the SD of the average of the same and previous days’ minimum and maximum temperatures. We first obtained location-specific temperature variability related-mortality associations based on a daily time series of 750 locations from the Multi-country Multi-city Collaborative Research Network. We subsequently constructed a multivariable meta-regression model with five predictors to estimate grid-specific temperature variability related-mortality associations across the globe. Finally, percentage excess in mortality and excess mortality rate were calculated to quantify the temperature variability-related mortality burden and to further explore its temporal trend over two decades. Findings: An increasing trend in temperature variability was identified at the global level from 2000 to 2019. Globally, 1 753 392 deaths (95% CI 1 159 901–2 357 718) were associated with temperature variability per year, accounting for
Published: 2022
Full Text: View/download PDF

12. Global, regional, and national burden of mortality associated with short-term temperature variability from 2000–19 : a three-stage modelling study

Author: Wu, Yao, Li, Shanshan, Zhao, Qi, Wen, Bo, Gasparrini, Antonio, Tong, Shilu, Overcenco, Ala, Urban, Aleš, Schneider, Alexandra, Entezari, Alireza, Vicedo-Cabrera, Ana Maria, Zanobetti, Antonella, Analitis, Antonis, Zeka, Ariana, Tobias, Aurelio, Nunes, Baltazar, Alahmad, Barrak, Armstrong, Ben, Forsberg, Bertil, Pan, Shih-Chun, Íñiguez, Carmen, Ameling, Caroline, De la Cruz Valencia, César, Åström, Christofer, Houthuijs, Danny, Van Dung, Do, Royé, Dominic, Indermitte, Ene, Lavigne, Eric, Mayvaneh, Fatemeh, Acquaotta, Fiorella, de'Donato, Francesca, Rao, Shilpa, Sera, Francesco, Carrasco-Escobar, Gabriel, Kan, Haidong, Orru, Hans, Kim, Ho, Holobaca, Iulian-Horia, Kyselý, Jan, Madureira, Joana, Schwartz, Joel, Jaakkola, Jouni J K, Katsouyanni, Klea, Hurtado Diaz, Magali, Ragettli, Martina S, Hashizume, Masahiro, Pascal, Mathilde, de Sousa Zanotti Stagliorio Coélho, Micheline, Ortega, Nicolás Valdés, Ryti, Niilo, Scovronick, Noah, Michelozzi, Paola, Correa, Patricia Matus, Goodman, Patrick, Nascimento Saldiva, Paulo Hilario, Abrutzky, Rosana, Osorio, Samuel, Dang, Tran Ngoc, Colistro, Valentina, Huber, Veronika, Lee, Whanhee, Seposo, Xerxes, Honda, Yasushi, Guo, Yue Leon, Bell, Michelle L, Guo, Yuming, Wu, Yao, Li, Shanshan, Zhao, Qi, Wen, Bo, Gasparrini, Antonio, Tong, Shilu, Overcenco, Ala, Urban, Aleš, Schneider, Alexandra, Entezari, Alireza, Vicedo-Cabrera, Ana Maria, Zanobetti, Antonella, Analitis, Antonis, Zeka, Ariana, Tobias, Aurelio, Nunes, Baltazar, Alahmad, Barrak, Armstrong, Ben, Forsberg, Bertil, Pan, Shih-Chun, Íñiguez, Carmen, Ameling, Caroline, De la Cruz Valencia, César, Åström, Christofer, Houthuijs, Danny, Van Dung, Do, Royé, Dominic, Indermitte, Ene, Lavigne, Eric, Mayvaneh, Fatemeh, Acquaotta, Fiorella, de'Donato, Francesca, Rao, Shilpa, Sera, Francesco, Carrasco-Escobar, Gabriel, Kan, Haidong, Orru, Hans, Kim, Ho, Holobaca, Iulian-Horia, Kyselý, Jan, Madureira, Joana, Schwartz, Joel, Jaakkola, Jouni J K, Katsouyanni, Klea, Hurtado Diaz, Magali, Ragettli, Martina S, Hashizume, Masahiro, Pascal, Mathilde, de Sousa Zanotti Stagliorio Coélho, Micheline, Ortega, Nicolás Valdés, Ryti, Niilo, Scovronick, Noah, Michelozzi, Paola, Correa, Patricia Matus, Goodman, Patrick, Nascimento Saldiva, Paulo Hilario, Abrutzky, Rosana, Osorio, Samuel, Dang, Tran Ngoc, Colistro, Valentina, Huber, Veronika, Lee, Whanhee, Seposo, Xerxes, Honda, Yasushi, Guo, Yue Leon, Bell, Michelle L, and Guo, Yuming
Abstract: Background: Increased mortality risk is associated with short-term temperature variability. However, to our knowledge, there has been no comprehensive assessment of the temperature variability-related mortality burden worldwide. In this study, using data from the MCC Collaborative Research Network, we first explored the association between temperature variability and mortality across 43 countries or regions. Then, to provide a more comprehensive picture of the global burden of mortality associated with temperature variability, global gridded temperature data with a resolution of 0·5° × 0·5° were used to assess the temperature variability-related mortality burden at the global, regional, and national levels. Furthermore, temporal trends in temperature variability-related mortality burden were also explored from 2000–19. Methods: In this modelling study, we applied a three-stage meta-analytical approach to assess the global temperature variability-related mortality burden at a spatial resolution of 0·5° × 0·5° from 2000–19. Temperature variability was calculated as the SD of the average of the same and previous days’ minimum and maximum temperatures. We first obtained location-specific temperature variability related-mortality associations based on a daily time series of 750 locations from the Multi-country Multi-city Collaborative Research Network. We subsequently constructed a multivariable meta-regression model with five predictors to estimate grid-specific temperature variability related-mortality associations across the globe. Finally, percentage excess in mortality and excess mortality rate were calculated to quantify the temperature variability-related mortality burden and to further explore its temporal trend over two decades. Findings: An increasing trend in temperature variability was identified at the global level from 2000 to 2019. Globally, 1 753 392 deaths (95% CI 1 159 901–2 357 718) were associated with temperature variability per year, accounting for
Published: 2022
Full Text: View/download PDF

13. Fluctuating temperature modifies heat-mortality association around the globe

Author: Wu, Yao, Wen, Bo, Li, Shanshan, Gasparrini, Antonio, Tong, Shilu, Overcenco, Ala, Urban, Aleš, Schneider, Alexandra, Entezari, Alireza, Vicedo-Cabrera, Ana Maria, Zanobetti, Antonella, Analitis, Antonis, Zeka, Ariana, Tobias, Aurelio, Alahmad, Barrak, Armstrong, Ben, Forsberg, Bertil, Íñiguez, Carmen, Ameling, Caroline, De la Cruz Valencia, César, Åström, Christofer, Houthuijs, Danny, Van Dung, Do, Royé, Dominic, Indermitte, Ene, Lavigne, Eric, Mayvaneh, Fatemeh, Acquaotta, Fiorella, de'Donato, Francesca, Sera, Francesco, Carrasco-Escobar, Gabriel, Kan, Haidong, Orru, Hans, Kim, Ho, Holobaca, Iulian-Horia, Kyselý, Jan, Madureira, Joana, Schwartz, Joel, Katsouyanni, Klea, Hurtado-Diaz, Magali, Ragettli, Martina S., Hashizume, Masahiro, Pascal, Mathilde, de Sousa Zanotti Stagliorio Coélho, Micheline, Scovronick, Noah, Michelozzi, Paola, Goodman, Patrick, Nascimento Saldiva, Paulo Hilario, Abrutzky, Rosana, Osorio, Samuel, Dang, Tran Ngoc, Colistro, Valentina, Huber, Veronika, Lee, Whanhee, Seposo, Xerxes, Honda, Yasushi, Bell, Michelle L., Guo, Yuming, Wu, Yao, Wen, Bo, Li, Shanshan, Gasparrini, Antonio, Tong, Shilu, Overcenco, Ala, Urban, Aleš, Schneider, Alexandra, Entezari, Alireza, Vicedo-Cabrera, Ana Maria, Zanobetti, Antonella, Analitis, Antonis, Zeka, Ariana, Tobias, Aurelio, Alahmad, Barrak, Armstrong, Ben, Forsberg, Bertil, Íñiguez, Carmen, Ameling, Caroline, De la Cruz Valencia, César, Åström, Christofer, Houthuijs, Danny, Van Dung, Do, Royé, Dominic, Indermitte, Ene, Lavigne, Eric, Mayvaneh, Fatemeh, Acquaotta, Fiorella, de'Donato, Francesca, Sera, Francesco, Carrasco-Escobar, Gabriel, Kan, Haidong, Orru, Hans, Kim, Ho, Holobaca, Iulian-Horia, Kyselý, Jan, Madureira, Joana, Schwartz, Joel, Katsouyanni, Klea, Hurtado-Diaz, Magali, Ragettli, Martina S., Hashizume, Masahiro, Pascal, Mathilde, de Sousa Zanotti Stagliorio Coélho, Micheline, Scovronick, Noah, Michelozzi, Paola, Goodman, Patrick, Nascimento Saldiva, Paulo Hilario, Abrutzky, Rosana, Osorio, Samuel, Dang, Tran Ngoc, Colistro, Valentina, Huber, Veronika, Lee, Whanhee, Seposo, Xerxes, Honda, Yasushi, Bell, Michelle L., and Guo, Yuming
Abstract: Studies have investigated the effects of heat and temperature variability (TV) on mortality. However, few assessed whether TV modifies the heat-mortality association. Data on daily temperature and mortality in the warm season were collected from 717 locations across 36 countries. TV was calculated as the standard deviation of the average of the same and previous days’ minimum and maximum temperatures. We used location-specific quasi-Poisson regression models with an interaction term between the cross-basis term for mean temperature and quartiles of TV to obtain heat-mortality associations under each quartile of TV, and then pooled estimates at the country, regional, and global levels. Results show the increased risk in heat-related mortality with increments in TV, accounting for 0.70% (95% confidence interval [CI]: −0.33 to 1.69), 1.34% (95% CI: −0.14 to 2.73), 1.99% (95% CI: 0.29–3.57), and 2.73% (95% CI: 0.76–4.50) of total deaths for Q1–Q4 (first quartile–fourth quartile) of TV. The modification effects of TV varied geographically. Central Europe had the highest attributable fractions (AFs), corresponding to 7.68% (95% CI: 5.25–9.89) of total deaths for Q4 of TV, while the lowest AFs were observed in North America, with the values for Q4 of 1.74% (95% CI: −0.09 to 3.39). TV had a significant modification effect on the heat-mortality association, causing a higher heat-related mortality burden with increments of TV. Implementing targeted strategies against heat exposure and fluctuant temperatures simultaneously would benefit public health.
Published: 2022
Full Text: View/download PDF

14. Fluctuating temperature modifies heat-mortality association around the globe

Author: Wu, Yao, Wen, Bo, Li, Shanshan, Gasparrini, Antonio, Tong, Shilu, Overcenco, Ala, Urban, Aleš, Schneider, Alexandra, Entezari, Alireza, Vicedo-Cabrera, Ana Maria, Zanobetti, Antonella, Analitis, Antonis, Zeka, Ariana, Tobias, Aurelio, Alahmad, Barrak, Armstrong, Ben, Forsberg, Bertil, Íñiguez, Carmen, Ameling, Caroline, De la Cruz Valencia, César, Åström, Christofer, Houthuijs, Danny, Van Dung, Do, Royé, Dominic, Indermitte, Ene, Lavigne, Eric, Mayvaneh, Fatemeh, Acquaotta, Fiorella, de'Donato, Francesca, Sera, Francesco, Carrasco-Escobar, Gabriel, Kan, Haidong, Orru, Hans, Kim, Ho, Holobaca, Iulian-Horia, Kyselý, Jan, Madureira, Joana, Schwartz, Joel, Katsouyanni, Klea, Hurtado-Diaz, Magali, Ragettli, Martina S., Hashizume, Masahiro, Pascal, Mathilde, de Sousa Zanotti Stagliorio Coélho, Micheline, Scovronick, Noah, Michelozzi, Paola, Goodman, Patrick, Nascimento Saldiva, Paulo Hilario, Abrutzky, Rosana, Osorio, Samuel, Dang, Tran Ngoc, Colistro, Valentina, Huber, Veronika, Lee, Whanhee, Seposo, Xerxes, Honda, Yasushi, Bell, Michelle L., Guo, Yuming, Wu, Yao, Wen, Bo, Li, Shanshan, Gasparrini, Antonio, Tong, Shilu, Overcenco, Ala, Urban, Aleš, Schneider, Alexandra, Entezari, Alireza, Vicedo-Cabrera, Ana Maria, Zanobetti, Antonella, Analitis, Antonis, Zeka, Ariana, Tobias, Aurelio, Alahmad, Barrak, Armstrong, Ben, Forsberg, Bertil, Íñiguez, Carmen, Ameling, Caroline, De la Cruz Valencia, César, Åström, Christofer, Houthuijs, Danny, Van Dung, Do, Royé, Dominic, Indermitte, Ene, Lavigne, Eric, Mayvaneh, Fatemeh, Acquaotta, Fiorella, de'Donato, Francesca, Sera, Francesco, Carrasco-Escobar, Gabriel, Kan, Haidong, Orru, Hans, Kim, Ho, Holobaca, Iulian-Horia, Kyselý, Jan, Madureira, Joana, Schwartz, Joel, Katsouyanni, Klea, Hurtado-Diaz, Magali, Ragettli, Martina S., Hashizume, Masahiro, Pascal, Mathilde, de Sousa Zanotti Stagliorio Coélho, Micheline, Scovronick, Noah, Michelozzi, Paola, Goodman, Patrick, Nascimento Saldiva, Paulo Hilario, Abrutzky, Rosana, Osorio, Samuel, Dang, Tran Ngoc, Colistro, Valentina, Huber, Veronika, Lee, Whanhee, Seposo, Xerxes, Honda, Yasushi, Bell, Michelle L., and Guo, Yuming
Abstract: Studies have investigated the effects of heat and temperature variability (TV) on mortality. However, few assessed whether TV modifies the heat-mortality association. Data on daily temperature and mortality in the warm season were collected from 717 locations across 36 countries. TV was calculated as the standard deviation of the average of the same and previous days’ minimum and maximum temperatures. We used location-specific quasi-Poisson regression models with an interaction term between the cross-basis term for mean temperature and quartiles of TV to obtain heat-mortality associations under each quartile of TV, and then pooled estimates at the country, regional, and global levels. Results show the increased risk in heat-related mortality with increments in TV, accounting for 0.70% (95% confidence interval [CI]: −0.33 to 1.69), 1.34% (95% CI: −0.14 to 2.73), 1.99% (95% CI: 0.29–3.57), and 2.73% (95% CI: 0.76–4.50) of total deaths for Q1–Q4 (first quartile–fourth quartile) of TV. The modification effects of TV varied geographically. Central Europe had the highest attributable fractions (AFs), corresponding to 7.68% (95% CI: 5.25–9.89) of total deaths for Q4 of TV, while the lowest AFs were observed in North America, with the values for Q4 of 1.74% (95% CI: −0.09 to 3.39). TV had a significant modification effect on the heat-mortality association, causing a higher heat-related mortality burden with increments of TV. Implementing targeted strategies against heat exposure and fluctuant temperatures simultaneously would benefit public health.
Published: 2022
Full Text: View/download PDF

15. Fluctuating temperature modifies heat-mortality association around the globe

Author: Wu, Yao, Wen, Bo, Li, Shanshan, Gasparrini, Antonio, Tong, Shilu, Overcenco, Ala, Urban, Aleš, Schneider, Alexandra, Entezari, Alireza, Vicedo-Cabrera, Ana Maria, Zanobetti, Antonella, Analitis, Antonis, Zeka, Ariana, Tobias, Aurelio, Alahmad, Barrak, Armstrong, Ben, Forsberg, Bertil, Íñiguez, Carmen, Ameling, Caroline, De la Cruz Valencia, César, Åström, Christofer, Houthuijs, Danny, Van Dung, Do, Royé, Dominic, Indermitte, Ene, Lavigne, Eric, Mayvaneh, Fatemeh, Acquaotta, Fiorella, de'Donato, Francesca, Sera, Francesco, Carrasco-Escobar, Gabriel, Kan, Haidong, Orru, Hans, Kim, Ho, Holobaca, Iulian-Horia, Kyselý, Jan, Madureira, Joana, Schwartz, Joel, Katsouyanni, Klea, Hurtado-Diaz, Magali, Ragettli, Martina S., Hashizume, Masahiro, Pascal, Mathilde, de Sousa Zanotti Stagliorio Coélho, Micheline, Scovronick, Noah, Michelozzi, Paola, Goodman, Patrick, Nascimento Saldiva, Paulo Hilario, Abrutzky, Rosana, Osorio, Samuel, Dang, Tran Ngoc, Colistro, Valentina, Huber, Veronika, Lee, Whanhee, Seposo, Xerxes, Honda, Yasushi, Bell, Michelle L., Guo, Yuming, Wu, Yao, Wen, Bo, Li, Shanshan, Gasparrini, Antonio, Tong, Shilu, Overcenco, Ala, Urban, Aleš, Schneider, Alexandra, Entezari, Alireza, Vicedo-Cabrera, Ana Maria, Zanobetti, Antonella, Analitis, Antonis, Zeka, Ariana, Tobias, Aurelio, Alahmad, Barrak, Armstrong, Ben, Forsberg, Bertil, Íñiguez, Carmen, Ameling, Caroline, De la Cruz Valencia, César, Åström, Christofer, Houthuijs, Danny, Van Dung, Do, Royé, Dominic, Indermitte, Ene, Lavigne, Eric, Mayvaneh, Fatemeh, Acquaotta, Fiorella, de'Donato, Francesca, Sera, Francesco, Carrasco-Escobar, Gabriel, Kan, Haidong, Orru, Hans, Kim, Ho, Holobaca, Iulian-Horia, Kyselý, Jan, Madureira, Joana, Schwartz, Joel, Katsouyanni, Klea, Hurtado-Diaz, Magali, Ragettli, Martina S., Hashizume, Masahiro, Pascal, Mathilde, de Sousa Zanotti Stagliorio Coélho, Micheline, Scovronick, Noah, Michelozzi, Paola, Goodman, Patrick, Nascimento Saldiva, Paulo Hilario, Abrutzky, Rosana, Osorio, Samuel, Dang, Tran Ngoc, Colistro, Valentina, Huber, Veronika, Lee, Whanhee, Seposo, Xerxes, Honda, Yasushi, Bell, Michelle L., and Guo, Yuming
Abstract: Studies have investigated the effects of heat and temperature variability (TV) on mortality. However, few assessed whether TV modifies the heat-mortality association. Data on daily temperature and mortality in the warm season were collected from 717 locations across 36 countries. TV was calculated as the standard deviation of the average of the same and previous days’ minimum and maximum temperatures. We used location-specific quasi-Poisson regression models with an interaction term between the cross-basis term for mean temperature and quartiles of TV to obtain heat-mortality associations under each quartile of TV, and then pooled estimates at the country, regional, and global levels. Results show the increased risk in heat-related mortality with increments in TV, accounting for 0.70% (95% confidence interval [CI]: −0.33 to 1.69), 1.34% (95% CI: −0.14 to 2.73), 1.99% (95% CI: 0.29–3.57), and 2.73% (95% CI: 0.76–4.50) of total deaths for Q1–Q4 (first quartile–fourth quartile) of TV. The modification effects of TV varied geographically. Central Europe had the highest attributable fractions (AFs), corresponding to 7.68% (95% CI: 5.25–9.89) of total deaths for Q4 of TV, while the lowest AFs were observed in North America, with the values for Q4 of 1.74% (95% CI: −0.09 to 3.39). TV had a significant modification effect on the heat-mortality association, causing a higher heat-related mortality burden with increments of TV. Implementing targeted strategies against heat exposure and fluctuant temperatures simultaneously would benefit public health.
Published: 2022
Full Text: View/download PDF

16. Fluctuating temperature modifies heat-mortality association around the globe

Author: Wu, Yao, Wen, Bo, Li, Shanshan, Gasparrini, Antonio, Tong, Shilu, Overcenco, Ala, Urban, Aleš, Schneider, Alexandra, Entezari, Alireza, Vicedo-Cabrera, Ana Maria, Zanobetti, Antonella, Analitis, Antonis, Zeka, Ariana, Tobias, Aurelio, Alahmad, Barrak, Armstrong, Ben, Forsberg, Bertil, Íñiguez, Carmen, Ameling, Caroline, De la Cruz Valencia, César, Åström, Christofer, Houthuijs, Danny, Van Dung, Do, Royé, Dominic, Indermitte, Ene, Lavigne, Eric, Mayvaneh, Fatemeh, Acquaotta, Fiorella, de'Donato, Francesca, Sera, Francesco, Carrasco-Escobar, Gabriel, Kan, Haidong, Orru, Hans, Kim, Ho, Holobaca, Iulian-Horia, Kyselý, Jan, Madureira, Joana, Schwartz, Joel, Katsouyanni, Klea, Hurtado-Diaz, Magali, Ragettli, Martina S., Hashizume, Masahiro, Pascal, Mathilde, de Sousa Zanotti Stagliorio Coélho, Micheline, Scovronick, Noah, Michelozzi, Paola, Goodman, Patrick, Nascimento Saldiva, Paulo Hilario, Abrutzky, Rosana, Osorio, Samuel, Dang, Tran Ngoc, Colistro, Valentina, Huber, Veronika, Lee, Whanhee, Seposo, Xerxes, Honda, Yasushi, Bell, Michelle L., Guo, Yuming, Wu, Yao, Wen, Bo, Li, Shanshan, Gasparrini, Antonio, Tong, Shilu, Overcenco, Ala, Urban, Aleš, Schneider, Alexandra, Entezari, Alireza, Vicedo-Cabrera, Ana Maria, Zanobetti, Antonella, Analitis, Antonis, Zeka, Ariana, Tobias, Aurelio, Alahmad, Barrak, Armstrong, Ben, Forsberg, Bertil, Íñiguez, Carmen, Ameling, Caroline, De la Cruz Valencia, César, Åström, Christofer, Houthuijs, Danny, Van Dung, Do, Royé, Dominic, Indermitte, Ene, Lavigne, Eric, Mayvaneh, Fatemeh, Acquaotta, Fiorella, de'Donato, Francesca, Sera, Francesco, Carrasco-Escobar, Gabriel, Kan, Haidong, Orru, Hans, Kim, Ho, Holobaca, Iulian-Horia, Kyselý, Jan, Madureira, Joana, Schwartz, Joel, Katsouyanni, Klea, Hurtado-Diaz, Magali, Ragettli, Martina S., Hashizume, Masahiro, Pascal, Mathilde, de Sousa Zanotti Stagliorio Coélho, Micheline, Scovronick, Noah, Michelozzi, Paola, Goodman, Patrick, Nascimento Saldiva, Paulo Hilario, Abrutzky, Rosana, Osorio, Samuel, Dang, Tran Ngoc, Colistro, Valentina, Huber, Veronika, Lee, Whanhee, Seposo, Xerxes, Honda, Yasushi, Bell, Michelle L., and Guo, Yuming
Abstract: Studies have investigated the effects of heat and temperature variability (TV) on mortality. However, few assessed whether TV modifies the heat-mortality association. Data on daily temperature and mortality in the warm season were collected from 717 locations across 36 countries. TV was calculated as the standard deviation of the average of the same and previous days’ minimum and maximum temperatures. We used location-specific quasi-Poisson regression models with an interaction term between the cross-basis term for mean temperature and quartiles of TV to obtain heat-mortality associations under each quartile of TV, and then pooled estimates at the country, regional, and global levels. Results show the increased risk in heat-related mortality with increments in TV, accounting for 0.70% (95% confidence interval [CI]: −0.33 to 1.69), 1.34% (95% CI: −0.14 to 2.73), 1.99% (95% CI: 0.29–3.57), and 2.73% (95% CI: 0.76–4.50) of total deaths for Q1–Q4 (first quartile–fourth quartile) of TV. The modification effects of TV varied geographically. Central Europe had the highest attributable fractions (AFs), corresponding to 7.68% (95% CI: 5.25–9.89) of total deaths for Q4 of TV, while the lowest AFs were observed in North America, with the values for Q4 of 1.74% (95% CI: −0.09 to 3.39). TV had a significant modification effect on the heat-mortality association, causing a higher heat-related mortality burden with increments of TV. Implementing targeted strategies against heat exposure and fluctuant temperatures simultaneously would benefit public health.
Published: 2022
Full Text: View/download PDF

17. Global, regional, and national burden of mortality associated with short-term temperature variability from 2000–19 : a three-stage modelling study

Author: Wu, Yao, Li, Shanshan, Zhao, Qi, Wen, Bo, Gasparrini, Antonio, Tong, Shilu, Overcenco, Ala, Urban, Aleš, Schneider, Alexandra, Entezari, Alireza, Vicedo-Cabrera, Ana Maria, Zanobetti, Antonella, Analitis, Antonis, Zeka, Ariana, Tobias, Aurelio, Nunes, Baltazar, Alahmad, Barrak, Armstrong, Ben, Forsberg, Bertil, Pan, Shih-Chun, Íñiguez, Carmen, Ameling, Caroline, De la Cruz Valencia, César, Åström, Christofer, Houthuijs, Danny, Van Dung, Do, Royé, Dominic, Indermitte, Ene, Lavigne, Eric, Mayvaneh, Fatemeh, Acquaotta, Fiorella, de'Donato, Francesca, Rao, Shilpa, Sera, Francesco, Carrasco-Escobar, Gabriel, Kan, Haidong, Orru, Hans, Kim, Ho, Holobaca, Iulian-Horia, Kyselý, Jan, Madureira, Joana, Schwartz, Joel, Jaakkola, Jouni J K, Katsouyanni, Klea, Hurtado Diaz, Magali, Ragettli, Martina S, Hashizume, Masahiro, Pascal, Mathilde, de Sousa Zanotti Stagliorio Coélho, Micheline, Ortega, Nicolás Valdés, Ryti, Niilo, Scovronick, Noah, Michelozzi, Paola, Correa, Patricia Matus, Goodman, Patrick, Nascimento Saldiva, Paulo Hilario, Abrutzky, Rosana, Osorio, Samuel, Dang, Tran Ngoc, Colistro, Valentina, Huber, Veronika, Lee, Whanhee, Seposo, Xerxes, Honda, Yasushi, Guo, Yue Leon, Bell, Michelle L, Guo, Yuming, Wu, Yao, Li, Shanshan, Zhao, Qi, Wen, Bo, Gasparrini, Antonio, Tong, Shilu, Overcenco, Ala, Urban, Aleš, Schneider, Alexandra, Entezari, Alireza, Vicedo-Cabrera, Ana Maria, Zanobetti, Antonella, Analitis, Antonis, Zeka, Ariana, Tobias, Aurelio, Nunes, Baltazar, Alahmad, Barrak, Armstrong, Ben, Forsberg, Bertil, Pan, Shih-Chun, Íñiguez, Carmen, Ameling, Caroline, De la Cruz Valencia, César, Åström, Christofer, Houthuijs, Danny, Van Dung, Do, Royé, Dominic, Indermitte, Ene, Lavigne, Eric, Mayvaneh, Fatemeh, Acquaotta, Fiorella, de'Donato, Francesca, Rao, Shilpa, Sera, Francesco, Carrasco-Escobar, Gabriel, Kan, Haidong, Orru, Hans, Kim, Ho, Holobaca, Iulian-Horia, Kyselý, Jan, Madureira, Joana, Schwartz, Joel, Jaakkola, Jouni J K, Katsouyanni, Klea, Hurtado Diaz, Magali, Ragettli, Martina S, Hashizume, Masahiro, Pascal, Mathilde, de Sousa Zanotti Stagliorio Coélho, Micheline, Ortega, Nicolás Valdés, Ryti, Niilo, Scovronick, Noah, Michelozzi, Paola, Correa, Patricia Matus, Goodman, Patrick, Nascimento Saldiva, Paulo Hilario, Abrutzky, Rosana, Osorio, Samuel, Dang, Tran Ngoc, Colistro, Valentina, Huber, Veronika, Lee, Whanhee, Seposo, Xerxes, Honda, Yasushi, Guo, Yue Leon, Bell, Michelle L, and Guo, Yuming
Abstract: Background: Increased mortality risk is associated with short-term temperature variability. However, to our knowledge, there has been no comprehensive assessment of the temperature variability-related mortality burden worldwide. In this study, using data from the MCC Collaborative Research Network, we first explored the association between temperature variability and mortality across 43 countries or regions. Then, to provide a more comprehensive picture of the global burden of mortality associated with temperature variability, global gridded temperature data with a resolution of 0·5° × 0·5° were used to assess the temperature variability-related mortality burden at the global, regional, and national levels. Furthermore, temporal trends in temperature variability-related mortality burden were also explored from 2000–19. Methods: In this modelling study, we applied a three-stage meta-analytical approach to assess the global temperature variability-related mortality burden at a spatial resolution of 0·5° × 0·5° from 2000–19. Temperature variability was calculated as the SD of the average of the same and previous days’ minimum and maximum temperatures. We first obtained location-specific temperature variability related-mortality associations based on a daily time series of 750 locations from the Multi-country Multi-city Collaborative Research Network. We subsequently constructed a multivariable meta-regression model with five predictors to estimate grid-specific temperature variability related-mortality associations across the globe. Finally, percentage excess in mortality and excess mortality rate were calculated to quantify the temperature variability-related mortality burden and to further explore its temporal trend over two decades. Findings: An increasing trend in temperature variability was identified at the global level from 2000 to 2019. Globally, 1 753 392 deaths (95% CI 1 159 901–2 357 718) were associated with temperature variability per year, accounting for
Published: 2022
Full Text: View/download PDF

18. Global, regional, and national burden of mortality associated with short-term temperature variability from 2000–19 : a three-stage modelling study

Author: Wu, Yao, Li, Shanshan, Zhao, Qi, Wen, Bo, Gasparrini, Antonio, Tong, Shilu, Overcenco, Ala, Urban, Aleš, Schneider, Alexandra, Entezari, Alireza, Vicedo-Cabrera, Ana Maria, Zanobetti, Antonella, Analitis, Antonis, Zeka, Ariana, Tobias, Aurelio, Nunes, Baltazar, Alahmad, Barrak, Armstrong, Ben, Forsberg, Bertil, Pan, Shih-Chun, Íñiguez, Carmen, Ameling, Caroline, De la Cruz Valencia, César, Åström, Christofer, Houthuijs, Danny, Van Dung, Do, Royé, Dominic, Indermitte, Ene, Lavigne, Eric, Mayvaneh, Fatemeh, Acquaotta, Fiorella, de'Donato, Francesca, Rao, Shilpa, Sera, Francesco, Carrasco-Escobar, Gabriel, Kan, Haidong, Orru, Hans, Kim, Ho, Holobaca, Iulian-Horia, Kyselý, Jan, Madureira, Joana, Schwartz, Joel, Jaakkola, Jouni J K, Katsouyanni, Klea, Hurtado Diaz, Magali, Ragettli, Martina S, Hashizume, Masahiro, Pascal, Mathilde, de Sousa Zanotti Stagliorio Coélho, Micheline, Ortega, Nicolás Valdés, Ryti, Niilo, Scovronick, Noah, Michelozzi, Paola, Correa, Patricia Matus, Goodman, Patrick, Nascimento Saldiva, Paulo Hilario, Abrutzky, Rosana, Osorio, Samuel, Dang, Tran Ngoc, Colistro, Valentina, Huber, Veronika, Lee, Whanhee, Seposo, Xerxes, Honda, Yasushi, Guo, Yue Leon, Bell, Michelle L, Guo, Yuming, Wu, Yao, Li, Shanshan, Zhao, Qi, Wen, Bo, Gasparrini, Antonio, Tong, Shilu, Overcenco, Ala, Urban, Aleš, Schneider, Alexandra, Entezari, Alireza, Vicedo-Cabrera, Ana Maria, Zanobetti, Antonella, Analitis, Antonis, Zeka, Ariana, Tobias, Aurelio, Nunes, Baltazar, Alahmad, Barrak, Armstrong, Ben, Forsberg, Bertil, Pan, Shih-Chun, Íñiguez, Carmen, Ameling, Caroline, De la Cruz Valencia, César, Åström, Christofer, Houthuijs, Danny, Van Dung, Do, Royé, Dominic, Indermitte, Ene, Lavigne, Eric, Mayvaneh, Fatemeh, Acquaotta, Fiorella, de'Donato, Francesca, Rao, Shilpa, Sera, Francesco, Carrasco-Escobar, Gabriel, Kan, Haidong, Orru, Hans, Kim, Ho, Holobaca, Iulian-Horia, Kyselý, Jan, Madureira, Joana, Schwartz, Joel, Jaakkola, Jouni J K, Katsouyanni, Klea, Hurtado Diaz, Magali, Ragettli, Martina S, Hashizume, Masahiro, Pascal, Mathilde, de Sousa Zanotti Stagliorio Coélho, Micheline, Ortega, Nicolás Valdés, Ryti, Niilo, Scovronick, Noah, Michelozzi, Paola, Correa, Patricia Matus, Goodman, Patrick, Nascimento Saldiva, Paulo Hilario, Abrutzky, Rosana, Osorio, Samuel, Dang, Tran Ngoc, Colistro, Valentina, Huber, Veronika, Lee, Whanhee, Seposo, Xerxes, Honda, Yasushi, Guo, Yue Leon, Bell, Michelle L, and Guo, Yuming
Abstract: Background: Increased mortality risk is associated with short-term temperature variability. However, to our knowledge, there has been no comprehensive assessment of the temperature variability-related mortality burden worldwide. In this study, using data from the MCC Collaborative Research Network, we first explored the association between temperature variability and mortality across 43 countries or regions. Then, to provide a more comprehensive picture of the global burden of mortality associated with temperature variability, global gridded temperature data with a resolution of 0·5° × 0·5° were used to assess the temperature variability-related mortality burden at the global, regional, and national levels. Furthermore, temporal trends in temperature variability-related mortality burden were also explored from 2000–19. Methods: In this modelling study, we applied a three-stage meta-analytical approach to assess the global temperature variability-related mortality burden at a spatial resolution of 0·5° × 0·5° from 2000–19. Temperature variability was calculated as the SD of the average of the same and previous days’ minimum and maximum temperatures. We first obtained location-specific temperature variability related-mortality associations based on a daily time series of 750 locations from the Multi-country Multi-city Collaborative Research Network. We subsequently constructed a multivariable meta-regression model with five predictors to estimate grid-specific temperature variability related-mortality associations across the globe. Finally, percentage excess in mortality and excess mortality rate were calculated to quantify the temperature variability-related mortality burden and to further explore its temporal trend over two decades. Findings: An increasing trend in temperature variability was identified at the global level from 2000 to 2019. Globally, 1 753 392 deaths (95% CI 1 159 901–2 357 718) were associated with temperature variability per year, accounting for
Published: 2022
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19. Fluctuating temperature modifies heat-mortality association around the globe

Author: Wu, Yao, Wen, Bo, Li, Shanshan, Gasparrini, Antonio, Tong, Shilu, Overcenco, Ala, Urban, Aleš, Schneider, Alexandra, Entezari, Alireza, Vicedo-Cabrera, Ana Maria, Zanobetti, Antonella, Analitis, Antonis, Zeka, Ariana, Tobias, Aurelio, Alahmad, Barrak, Armstrong, Ben, Forsberg, Bertil, Íñiguez, Carmen, Ameling, Caroline, De la Cruz Valencia, César, Åström, Christofer, Houthuijs, Danny, Van Dung, Do, Royé, Dominic, Indermitte, Ene, Lavigne, Eric, Mayvaneh, Fatemeh, Acquaotta, Fiorella, de'Donato, Francesca, Sera, Francesco, Carrasco-Escobar, Gabriel, Kan, Haidong, Orru, Hans, Kim, Ho, Holobaca, Iulian-Horia, Kyselý, Jan, Madureira, Joana, Schwartz, Joel, Katsouyanni, Klea, Hurtado-Diaz, Magali, Ragettli, Martina S., Hashizume, Masahiro, Pascal, Mathilde, de Sousa Zanotti Stagliorio Coélho, Micheline, Scovronick, Noah, Michelozzi, Paola, Goodman, Patrick, Nascimento Saldiva, Paulo Hilario, Abrutzky, Rosana, Osorio, Samuel, Dang, Tran Ngoc, Colistro, Valentina, Huber, Veronika, Lee, Whanhee, Seposo, Xerxes, Honda, Yasushi, Bell, Michelle L., Guo, Yuming, Wu, Yao, Wen, Bo, Li, Shanshan, Gasparrini, Antonio, Tong, Shilu, Overcenco, Ala, Urban, Aleš, Schneider, Alexandra, Entezari, Alireza, Vicedo-Cabrera, Ana Maria, Zanobetti, Antonella, Analitis, Antonis, Zeka, Ariana, Tobias, Aurelio, Alahmad, Barrak, Armstrong, Ben, Forsberg, Bertil, Íñiguez, Carmen, Ameling, Caroline, De la Cruz Valencia, César, Åström, Christofer, Houthuijs, Danny, Van Dung, Do, Royé, Dominic, Indermitte, Ene, Lavigne, Eric, Mayvaneh, Fatemeh, Acquaotta, Fiorella, de'Donato, Francesca, Sera, Francesco, Carrasco-Escobar, Gabriel, Kan, Haidong, Orru, Hans, Kim, Ho, Holobaca, Iulian-Horia, Kyselý, Jan, Madureira, Joana, Schwartz, Joel, Katsouyanni, Klea, Hurtado-Diaz, Magali, Ragettli, Martina S., Hashizume, Masahiro, Pascal, Mathilde, de Sousa Zanotti Stagliorio Coélho, Micheline, Scovronick, Noah, Michelozzi, Paola, Goodman, Patrick, Nascimento Saldiva, Paulo Hilario, Abrutzky, Rosana, Osorio, Samuel, Dang, Tran Ngoc, Colistro, Valentina, Huber, Veronika, Lee, Whanhee, Seposo, Xerxes, Honda, Yasushi, Bell, Michelle L., and Guo, Yuming
Abstract: Studies have investigated the effects of heat and temperature variability (TV) on mortality. However, few assessed whether TV modifies the heat-mortality association. Data on daily temperature and mortality in the warm season were collected from 717 locations across 36 countries. TV was calculated as the standard deviation of the average of the same and previous days’ minimum and maximum temperatures. We used location-specific quasi-Poisson regression models with an interaction term between the cross-basis term for mean temperature and quartiles of TV to obtain heat-mortality associations under each quartile of TV, and then pooled estimates at the country, regional, and global levels. Results show the increased risk in heat-related mortality with increments in TV, accounting for 0.70% (95% confidence interval [CI]: −0.33 to 1.69), 1.34% (95% CI: −0.14 to 2.73), 1.99% (95% CI: 0.29–3.57), and 2.73% (95% CI: 0.76–4.50) of total deaths for Q1–Q4 (first quartile–fourth quartile) of TV. The modification effects of TV varied geographically. Central Europe had the highest attributable fractions (AFs), corresponding to 7.68% (95% CI: 5.25–9.89) of total deaths for Q4 of TV, while the lowest AFs were observed in North America, with the values for Q4 of 1.74% (95% CI: −0.09 to 3.39). TV had a significant modification effect on the heat-mortality association, causing a higher heat-related mortality burden with increments of TV. Implementing targeted strategies against heat exposure and fluctuant temperatures simultaneously would benefit public health.
Published: 2022
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20. Ambient carbon monoxide and daily mortality: a global time-series study in 337 cities

Author: Chen, Kai, Breitner, Susanne, Wolf, Kathrin, Stafoggia, Massimo, Sera, Francesco, Vicedo-Cabrera, Ana M., Guo, Yuming, Tong, Shilu, Lavigne, Eric, Matus, Patricia, Valdés, Nicolás, Kan, Haidong, Jaakkola, Jouni J. K., Ryti, Niilo R. I., Huber, Veronika, Scortichini, Matteo, Hashizume, Masahiro, Honda, Yasushi, Nunes, Baltazar, Madureira, Joana, Holobâcă, Iulian Horia, Fratianni, Simona, Kim, Ho, Lee, Whanhee, Tobias, Aurelio, Íñiguez, Carmen, Forsberg, Bertil, Åström, Christofer, Ragettli, Martina S., Guo, Yue-Liang Leon, Chen, Bing-Yu, Li, Shanshan, Milojevic, Ai, Zanobetti, Antonella, Schwartz, Joel, Bell, Michelle L., Gasparrini, Antonio, Schneider, Alexandra, Chen, Kai, Breitner, Susanne, Wolf, Kathrin, Stafoggia, Massimo, Sera, Francesco, Vicedo-Cabrera, Ana M., Guo, Yuming, Tong, Shilu, Lavigne, Eric, Matus, Patricia, Valdés, Nicolás, Kan, Haidong, Jaakkola, Jouni J. K., Ryti, Niilo R. I., Huber, Veronika, Scortichini, Matteo, Hashizume, Masahiro, Honda, Yasushi, Nunes, Baltazar, Madureira, Joana, Holobâcă, Iulian Horia, Fratianni, Simona, Kim, Ho, Lee, Whanhee, Tobias, Aurelio, Íñiguez, Carmen, Forsberg, Bertil, Åström, Christofer, Ragettli, Martina S., Guo, Yue-Liang Leon, Chen, Bing-Yu, Li, Shanshan, Milojevic, Ai, Zanobetti, Antonella, Schwartz, Joel, Bell, Michelle L., Gasparrini, Antonio, and Schneider, Alexandra
Abstract: Background: Epidemiological evidence on short-term association between ambient carbon monoxide (CO) and mortality is inconclusive and limited to single cities, regions, or countries. Generalisation of results from previous studies is hindered by potential publication bias and different modelling approaches. We therefore assessed the association between short-term exposure to ambient CO and daily mortality in a multicity, multicountry setting. Methods: We collected daily data on air pollution, meteorology, and total mortality from 337 cities in 18 countries or regions, covering various periods from 1979 to 2016. All included cities had at least 2 years of both CO and mortality data. We estimated city-specific associations using confounder-adjusted generalised additive models with a quasi-Poisson distribution, and then pooled the estimates, accounting for their statistical uncertainty, using a random-effects multilevel meta-analytical model. We also assessed the overall shape of the exposure–response curve and evaluated the possibility of a threshold below which health is not affected. Findings: Overall, a 1 mg/m3 increase in the average CO concentration of the previous day was associated with a 0·91% (95% CI 0·32–1·50) increase in daily total mortality. The pooled exposure–response curve showed a continuously elevated mortality risk with increasing CO concentrations, suggesting no threshold. The exposure–response curve was steeper at daily CO levels lower than 1 mg/m3, indicating greater risk of mortality per increment in CO exposure, and persisted at daily concentrations as low as 0·6 mg/m3 or less. The association remained similar after adjustment for ozone but was attenuated after adjustment for particulate matter or sulphur dioxide, or even reduced to null after adjustment for nitrogen dioxide. Interpretation: This international study is by far the largest epidemiological investigation on short-term CO-related mortality. We found significant associations between
Published: 2021
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21. Ambient carbon monoxide and daily mortality: a global time-series study in 337 cities

Author: Chen, Kai, Breitner, Susanne, Wolf, Kathrin, Stafoggia, Massimo, Sera, Francesco, Vicedo-Cabrera, Ana M., Guo, Yuming, Tong, Shilu, Lavigne, Eric, Matus, Patricia, Valdés, Nicolás, Kan, Haidong, Jaakkola, Jouni J. K., Ryti, Niilo R. I., Huber, Veronika, Scortichini, Matteo, Hashizume, Masahiro, Honda, Yasushi, Nunes, Baltazar, Madureira, Joana, Holobâcă, Iulian Horia, Fratianni, Simona, Kim, Ho, Lee, Whanhee, Tobias, Aurelio, Íñiguez, Carmen, Forsberg, Bertil, Åström, Christofer, Ragettli, Martina S., Guo, Yue-Liang Leon, Chen, Bing-Yu, Li, Shanshan, Milojevic, Ai, Zanobetti, Antonella, Schwartz, Joel, Bell, Michelle L., Gasparrini, Antonio, Schneider, Alexandra, Chen, Kai, Breitner, Susanne, Wolf, Kathrin, Stafoggia, Massimo, Sera, Francesco, Vicedo-Cabrera, Ana M., Guo, Yuming, Tong, Shilu, Lavigne, Eric, Matus, Patricia, Valdés, Nicolás, Kan, Haidong, Jaakkola, Jouni J. K., Ryti, Niilo R. I., Huber, Veronika, Scortichini, Matteo, Hashizume, Masahiro, Honda, Yasushi, Nunes, Baltazar, Madureira, Joana, Holobâcă, Iulian Horia, Fratianni, Simona, Kim, Ho, Lee, Whanhee, Tobias, Aurelio, Íñiguez, Carmen, Forsberg, Bertil, Åström, Christofer, Ragettli, Martina S., Guo, Yue-Liang Leon, Chen, Bing-Yu, Li, Shanshan, Milojevic, Ai, Zanobetti, Antonella, Schwartz, Joel, Bell, Michelle L., Gasparrini, Antonio, and Schneider, Alexandra
Abstract: Background: Epidemiological evidence on short-term association between ambient carbon monoxide (CO) and mortality is inconclusive and limited to single cities, regions, or countries. Generalisation of results from previous studies is hindered by potential publication bias and different modelling approaches. We therefore assessed the association between short-term exposure to ambient CO and daily mortality in a multicity, multicountry setting. Methods: We collected daily data on air pollution, meteorology, and total mortality from 337 cities in 18 countries or regions, covering various periods from 1979 to 2016. All included cities had at least 2 years of both CO and mortality data. We estimated city-specific associations using confounder-adjusted generalised additive models with a quasi-Poisson distribution, and then pooled the estimates, accounting for their statistical uncertainty, using a random-effects multilevel meta-analytical model. We also assessed the overall shape of the exposure–response curve and evaluated the possibility of a threshold below which health is not affected. Findings: Overall, a 1 mg/m3 increase in the average CO concentration of the previous day was associated with a 0·91% (95% CI 0·32–1·50) increase in daily total mortality. The pooled exposure–response curve showed a continuously elevated mortality risk with increasing CO concentrations, suggesting no threshold. The exposure–response curve was steeper at daily CO levels lower than 1 mg/m3, indicating greater risk of mortality per increment in CO exposure, and persisted at daily concentrations as low as 0·6 mg/m3 or less. The association remained similar after adjustment for ozone but was attenuated after adjustment for particulate matter or sulphur dioxide, or even reduced to null after adjustment for nitrogen dioxide. Interpretation: This international study is by far the largest epidemiological investigation on short-term CO-related mortality. We found significant associations between
Published: 2021
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22. Ambient carbon monoxide and daily mortality: a global time-series study in 337 cities

Author: Chen, Kai, Breitner, Susanne, Wolf, Kathrin, Stafoggia, Massimo, Sera, Francesco, Vicedo-Cabrera, Ana M., Guo, Yuming, Tong, Shilu, Lavigne, Eric, Matus, Patricia, Valdés, Nicolás, Kan, Haidong, Jaakkola, Jouni J. K., Ryti, Niilo R. I., Huber, Veronika, Scortichini, Matteo, Hashizume, Masahiro, Honda, Yasushi, Nunes, Baltazar, Madureira, Joana, Holobâcă, Iulian Horia, Fratianni, Simona, Kim, Ho, Lee, Whanhee, Tobias, Aurelio, Íñiguez, Carmen, Forsberg, Bertil, Åström, Christofer, Ragettli, Martina S., Guo, Yue-Liang Leon, Chen, Bing-Yu, Li, Shanshan, Milojevic, Ai, Zanobetti, Antonella, Schwartz, Joel, Bell, Michelle L., Gasparrini, Antonio, Schneider, Alexandra, Chen, Kai, Breitner, Susanne, Wolf, Kathrin, Stafoggia, Massimo, Sera, Francesco, Vicedo-Cabrera, Ana M., Guo, Yuming, Tong, Shilu, Lavigne, Eric, Matus, Patricia, Valdés, Nicolás, Kan, Haidong, Jaakkola, Jouni J. K., Ryti, Niilo R. I., Huber, Veronika, Scortichini, Matteo, Hashizume, Masahiro, Honda, Yasushi, Nunes, Baltazar, Madureira, Joana, Holobâcă, Iulian Horia, Fratianni, Simona, Kim, Ho, Lee, Whanhee, Tobias, Aurelio, Íñiguez, Carmen, Forsberg, Bertil, Åström, Christofer, Ragettli, Martina S., Guo, Yue-Liang Leon, Chen, Bing-Yu, Li, Shanshan, Milojevic, Ai, Zanobetti, Antonella, Schwartz, Joel, Bell, Michelle L., Gasparrini, Antonio, and Schneider, Alexandra
Abstract: Background: Epidemiological evidence on short-term association between ambient carbon monoxide (CO) and mortality is inconclusive and limited to single cities, regions, or countries. Generalisation of results from previous studies is hindered by potential publication bias and different modelling approaches. We therefore assessed the association between short-term exposure to ambient CO and daily mortality in a multicity, multicountry setting. Methods: We collected daily data on air pollution, meteorology, and total mortality from 337 cities in 18 countries or regions, covering various periods from 1979 to 2016. All included cities had at least 2 years of both CO and mortality data. We estimated city-specific associations using confounder-adjusted generalised additive models with a quasi-Poisson distribution, and then pooled the estimates, accounting for their statistical uncertainty, using a random-effects multilevel meta-analytical model. We also assessed the overall shape of the exposure–response curve and evaluated the possibility of a threshold below which health is not affected. Findings: Overall, a 1 mg/m3 increase in the average CO concentration of the previous day was associated with a 0·91% (95% CI 0·32–1·50) increase in daily total mortality. The pooled exposure–response curve showed a continuously elevated mortality risk with increasing CO concentrations, suggesting no threshold. The exposure–response curve was steeper at daily CO levels lower than 1 mg/m3, indicating greater risk of mortality per increment in CO exposure, and persisted at daily concentrations as low as 0·6 mg/m3 or less. The association remained similar after adjustment for ozone but was attenuated after adjustment for particulate matter or sulphur dioxide, or even reduced to null after adjustment for nitrogen dioxide. Interpretation: This international study is by far the largest epidemiological investigation on short-term CO-related mortality. We found significant associations between
Published: 2021
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23. Ambient carbon monoxide and daily mortality: a global time-series study in 337 cities

Author: Chen, Kai, Breitner, Susanne, Wolf, Kathrin, Stafoggia, Massimo, Sera, Francesco, Vicedo-Cabrera, Ana M., Guo, Yuming, Tong, Shilu, Lavigne, Eric, Matus, Patricia, Valdés, Nicolás, Kan, Haidong, Jaakkola, Jouni J. K., Ryti, Niilo R. I., Huber, Veronika, Scortichini, Matteo, Hashizume, Masahiro, Honda, Yasushi, Nunes, Baltazar, Madureira, Joana, Holobâcă, Iulian Horia, Fratianni, Simona, Kim, Ho, Lee, Whanhee, Tobias, Aurelio, Íñiguez, Carmen, Forsberg, Bertil, Åström, Christofer, Ragettli, Martina S., Guo, Yue-Liang Leon, Chen, Bing-Yu, Li, Shanshan, Milojevic, Ai, Zanobetti, Antonella, Schwartz, Joel, Bell, Michelle L., Gasparrini, Antonio, Schneider, Alexandra, Chen, Kai, Breitner, Susanne, Wolf, Kathrin, Stafoggia, Massimo, Sera, Francesco, Vicedo-Cabrera, Ana M., Guo, Yuming, Tong, Shilu, Lavigne, Eric, Matus, Patricia, Valdés, Nicolás, Kan, Haidong, Jaakkola, Jouni J. K., Ryti, Niilo R. I., Huber, Veronika, Scortichini, Matteo, Hashizume, Masahiro, Honda, Yasushi, Nunes, Baltazar, Madureira, Joana, Holobâcă, Iulian Horia, Fratianni, Simona, Kim, Ho, Lee, Whanhee, Tobias, Aurelio, Íñiguez, Carmen, Forsberg, Bertil, Åström, Christofer, Ragettli, Martina S., Guo, Yue-Liang Leon, Chen, Bing-Yu, Li, Shanshan, Milojevic, Ai, Zanobetti, Antonella, Schwartz, Joel, Bell, Michelle L., Gasparrini, Antonio, and Schneider, Alexandra
Abstract: Background: Epidemiological evidence on short-term association between ambient carbon monoxide (CO) and mortality is inconclusive and limited to single cities, regions, or countries. Generalisation of results from previous studies is hindered by potential publication bias and different modelling approaches. We therefore assessed the association between short-term exposure to ambient CO and daily mortality in a multicity, multicountry setting. Methods: We collected daily data on air pollution, meteorology, and total mortality from 337 cities in 18 countries or regions, covering various periods from 1979 to 2016. All included cities had at least 2 years of both CO and mortality data. We estimated city-specific associations using confounder-adjusted generalised additive models with a quasi-Poisson distribution, and then pooled the estimates, accounting for their statistical uncertainty, using a random-effects multilevel meta-analytical model. We also assessed the overall shape of the exposure–response curve and evaluated the possibility of a threshold below which health is not affected. Findings: Overall, a 1 mg/m3 increase in the average CO concentration of the previous day was associated with a 0·91% (95% CI 0·32–1·50) increase in daily total mortality. The pooled exposure–response curve showed a continuously elevated mortality risk with increasing CO concentrations, suggesting no threshold. The exposure–response curve was steeper at daily CO levels lower than 1 mg/m3, indicating greater risk of mortality per increment in CO exposure, and persisted at daily concentrations as low as 0·6 mg/m3 or less. The association remained similar after adjustment for ozone but was attenuated after adjustment for particulate matter or sulphur dioxide, or even reduced to null after adjustment for nitrogen dioxide. Interpretation: This international study is by far the largest epidemiological investigation on short-term CO-related mortality. We found significant associations between
Published: 2021
Full Text: View/download PDF

24. Ambient carbon monoxide and daily mortality: a global time-series study in 337 cities

Author: Chen, Kai, Breitner, Susanne, Wolf, Kathrin, Stafoggia, Massimo, Sera, Francesco, Vicedo-Cabrera, Ana M., Guo, Yuming, Tong, Shilu, Lavigne, Eric, Matus, Patricia, Valdés, Nicolás, Kan, Haidong, Jaakkola, Jouni J. K., Ryti, Niilo R. I., Huber, Veronika, Scortichini, Matteo, Hashizume, Masahiro, Honda, Yasushi, Nunes, Baltazar, Madureira, Joana, Holobâcă, Iulian Horia, Fratianni, Simona, Kim, Ho, Lee, Whanhee, Tobias, Aurelio, Íñiguez, Carmen, Forsberg, Bertil, Åström, Christofer, Ragettli, Martina S., Guo, Yue-Liang Leon, Chen, Bing-Yu, Li, Shanshan, Milojevic, Ai, Zanobetti, Antonella, Schwartz, Joel, Bell, Michelle L., Gasparrini, Antonio, Schneider, Alexandra, Chen, Kai, Breitner, Susanne, Wolf, Kathrin, Stafoggia, Massimo, Sera, Francesco, Vicedo-Cabrera, Ana M., Guo, Yuming, Tong, Shilu, Lavigne, Eric, Matus, Patricia, Valdés, Nicolás, Kan, Haidong, Jaakkola, Jouni J. K., Ryti, Niilo R. I., Huber, Veronika, Scortichini, Matteo, Hashizume, Masahiro, Honda, Yasushi, Nunes, Baltazar, Madureira, Joana, Holobâcă, Iulian Horia, Fratianni, Simona, Kim, Ho, Lee, Whanhee, Tobias, Aurelio, Íñiguez, Carmen, Forsberg, Bertil, Åström, Christofer, Ragettli, Martina S., Guo, Yue-Liang Leon, Chen, Bing-Yu, Li, Shanshan, Milojevic, Ai, Zanobetti, Antonella, Schwartz, Joel, Bell, Michelle L., Gasparrini, Antonio, and Schneider, Alexandra
Abstract: Background: Epidemiological evidence on short-term association between ambient carbon monoxide (CO) and mortality is inconclusive and limited to single cities, regions, or countries. Generalisation of results from previous studies is hindered by potential publication bias and different modelling approaches. We therefore assessed the association between short-term exposure to ambient CO and daily mortality in a multicity, multicountry setting. Methods: We collected daily data on air pollution, meteorology, and total mortality from 337 cities in 18 countries or regions, covering various periods from 1979 to 2016. All included cities had at least 2 years of both CO and mortality data. We estimated city-specific associations using confounder-adjusted generalised additive models with a quasi-Poisson distribution, and then pooled the estimates, accounting for their statistical uncertainty, using a random-effects multilevel meta-analytical model. We also assessed the overall shape of the exposure–response curve and evaluated the possibility of a threshold below which health is not affected. Findings: Overall, a 1 mg/m3 increase in the average CO concentration of the previous day was associated with a 0·91% (95% CI 0·32–1·50) increase in daily total mortality. The pooled exposure–response curve showed a continuously elevated mortality risk with increasing CO concentrations, suggesting no threshold. The exposure–response curve was steeper at daily CO levels lower than 1 mg/m3, indicating greater risk of mortality per increment in CO exposure, and persisted at daily concentrations as low as 0·6 mg/m3 or less. The association remained similar after adjustment for ozone but was attenuated after adjustment for particulate matter or sulphur dioxide, or even reduced to null after adjustment for nitrogen dioxide. Interpretation: This international study is by far the largest epidemiological investigation on short-term CO-related mortality. We found significant associations between
Published: 2021
Full Text: View/download PDF

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24 results on '"Ragettli, Martina S."'

1. Comparison for the effects of different components of temperature variability on mortality : A multi-country time-series study

2. Comparison for the effects of different components of temperature variability on mortality : A multi-country time-series study

3. Comparison for the effects of different components of temperature variability on mortality : A multi-country time-series study

4. Comparison for the effects of different components of temperature variability on mortality : A multi-country time-series study

5. Heat-related cardiorespiratory mortality : effect modification by air pollution across 482 cities from 24 countries

6. Heat-related cardiorespiratory mortality : effect modification by air pollution across 482 cities from 24 countries

7. Heat-related cardiorespiratory mortality : effect modification by air pollution across 482 cities from 24 countries

8. Heat-related cardiorespiratory mortality : effect modification by air pollution across 482 cities from 24 countries

9. Heat-related cardiorespiratory mortality : effect modification by air pollution across 482 cities from 24 countries

10. Global, regional, and national burden of mortality associated with short-term temperature variability from 2000–19 : a three-stage modelling study

11. Global, regional, and national burden of mortality associated with short-term temperature variability from 2000–19 : a three-stage modelling study

12. Global, regional, and national burden of mortality associated with short-term temperature variability from 2000–19 : a three-stage modelling study

13. Fluctuating temperature modifies heat-mortality association around the globe

14. Fluctuating temperature modifies heat-mortality association around the globe

15. Fluctuating temperature modifies heat-mortality association around the globe

16. Fluctuating temperature modifies heat-mortality association around the globe

17. Global, regional, and national burden of mortality associated with short-term temperature variability from 2000–19 : a three-stage modelling study

18. Global, regional, and national burden of mortality associated with short-term temperature variability from 2000–19 : a three-stage modelling study

19. Fluctuating temperature modifies heat-mortality association around the globe

20. Ambient carbon monoxide and daily mortality: a global time-series study in 337 cities

21. Ambient carbon monoxide and daily mortality: a global time-series study in 337 cities

22. Ambient carbon monoxide and daily mortality: a global time-series study in 337 cities

23. Ambient carbon monoxide and daily mortality: a global time-series study in 337 cities

24. Ambient carbon monoxide and daily mortality: a global time-series study in 337 cities

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24 results on '"Ragettli, Martina S."'

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