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Congenital cataract is a leading cause of childhood blindness. Early diagnosis and treatment are important because of the high risk of amblyopia. Newborn babies should be screened early. Often the cataract is regarded as idiopathic; it can be genetic but is frequently associated with other systemic or ocular abnormalities which can influence the final visual outcome. Visual rehabilitation of congenital cataract includes optical correction of aphakia and amblyopia treatment. [ABSTRACT FROM AUTHOR]

Purpose: To investigate the wound healing effect of topical and subconjunctival Coenzyme Q10 (CoQ) in an experimental trabeculectomy model, and to compare the outcomes with mitomycin C and bevacizumab. Materials and Methods: Thirty eyes of 27 Wistar Albino rats were included. Group 1 was the control group and the other four groups were mitomycin C (group 2), topical CoQ (group 3), subconjunctival CoQ (group 4), and bevacizumab (group 5). Conjunctival and scleral incisions were made to mimic the trabeculectomy wound. After the rats were sacrificed, histological sections were examined for vasculogenesis, VEGF and TGF-β1 positivity. Results: The mean vascularization score was lowest in groups 3 and 4 (0.5±0.55). It was followed by group 2 (1.0± 0.89), group 5 (1.5±1.0), and control group (2.5±0.55). The eyes in group 2, 3 and 4 showed significantly less vascularization than the control group (p = 0.015, p <0.01, p <0.01). VEGF and TGF-β1 positivity scores were lowest in groups 3 and 4 (1.48±0.45). This was followed by group 2 (2.0±0.34), group 5 (3.5±0.3), and control group (3.94±0.5). TGF-β1 and VEGF positive cells were significantly lower in groups 2, 3 and 4 than group 1 (p <0.01). TGF-β1 and VEGF positivity in groups 3 and 4 were significantly lower than the group 2 (p = 0.04). Conclusion: The application of topical and subconjunctival CoQ resulted in inhibition of vasculogenesis and reduction of TGF-β1 and VEGFpositive cells in trabeculectomy wound healing model. Topical or subconjunctival application of CoQ in trabeculectomy surgery may provide positive effects on wound healing.. [ABSTRACT FROM AUTHOR]

Purpose: To evaluate the factors affecting visual prognosis in bilateral pediatric cataracts and the complications of surgery. Materials and method: The records of 40 patients operated for bilateral congenital cataract at GÜTF Eye Clinic between 2010-2018 were retrospectively analyzed. Peroperatively capsulotomy, lens aspiration, posterior capsulotomy and anterior vitrectomy were performed. Primary iol implantation was performed in cases over one year of age. Secondary IOL implantation was performed at 2 years of age unless contraindicated. Visual acuity, intraocular pressure, presence of strabismus, amblyopia, nystagmus and surgical complications were evaluated. Results: The mean follow-up period was 4 years (1 month-8 years). 22 of the cases were male (55%) and 18 were female (45%). Seventeen patients (42.5%) underwent surgery before 3 months of age, and 23 patients (57.5%) underwent surgery after 3 months of age. 8 out of 30 patients who left aphakic went for secondary IOL implantation at the mean age of 5 years. The mean postoperative BCVA was 0.4 logMAR±0.4 (P +/ - 0 logMAR). The BCVA of the group undergoing IOL implantation was statistically higher (p = 0.007). Nystagmus was present in 6 out of 22 patients who left aphakic where postoperative nystagmus was recorded 3 out of 18 patients with IOL implanted. Two cases showed posterior capsule opasification, where, 1 retinal detachment, 1 glaucoma and 1 IOL subluxation cases were recorded as complications. Conclusion: IOL implantation was associated with good visual prognosis and the presence of nystagmus was associated with poor visual prognosis in bilateral childhood cataracts. [ABSTRACT FROM AUTHOR]

Objective: To evaluate treatment outcomes in unilateral childhood cataracts. Material and methods: Records of 21 patients with unilateral congenital or juvenile cataracts who were operated in Gazi University Hospital between 2010 and 2017 were retrospectively reviewed. Anterior capsulotomy, lens aspiration, posterior capsulotomy and anterior vitrectomy were performed. Primary intraocular lens (IOL) implantation was performed in cases older than 1 year of age. Secondary IOL implantation was performed after 2 years of age in those who left aphakic. Visual acuity, intraocular pressure, refraction error, compliance with amblyopia treatment and complications were evaluated. Results: The mean follow-up was 43 (6-108) months. The mean age at the time of surgery was 5 (1-10) months for the 14 cases with congenital onset and 4 (1.5-15) years for the 7 cases with juvenile onset. Six of the 14 patients who left aphakic under one year of age underwent secondary IOL implantation at an average of 35 month. The final VA was 0.64logMAR in the congenital group and 0.19logMAR in the juvenile group (p=0.02). 28.6% of congenital cases were operated in the first 6 weeks of life. Surgery in the first 6 weeks provided better visual outcome than did late surgery (=6 weeks=0.30logMAR,> 6 weeks=0.77logMAR, p=0.012). The most common complication was deprivation-induced strabismus (29%). PCO was not seen in any of the patients. Glaucoma was observed in one case. Conclusion: Good visual results can be obtained with early surgery and effective amblyopia treatment in unilateral childhood cataracts. Families should be well informed, and amblyopia treatment and regular follow-up examinations should be started promptly. [ABSTRACT FROM AUTHOR]

Phakomatosis pigmentovascularis (PPV) is a group of diseases that defined as the coexistence of vascularized and pigmented nevi. Patients with PPV often have ophthalmic abnormalities including ocular melanocytosis, goniodysgenesis, congenital glaucoma and choroidal melanoma. In this report, ophthalmic involvements of PPV and our approach to a PPV case with congenital glaucoma and ocular melanocytosis is being discussed. [ABSTRACT FROM AUTHOR]

Trabeculotomy is a Schlemm canal surgery to reduce the juxtacanalicular resistance between the trabecular meshwork and Schlemm channel which plays a major role in the pathophysiology of primary open angle glaucoma. To overcome the complications of standard trabeculectomy such as hypotony and late onset bleb related problems, alternative glaucoma surgeries have been performed. Among these the trabeculotomy has increasingly become popular. The effectiveness of trabeculotomy is well known in pediatric and congenital glaucomas. In recent years, the reports for suture and microcatheter 360 degree circumferential trabeculotomy increased its application for the treatment of adult glaucoma. Classically the trabeculotomy is performed ab externo however; it can also be performed ab interno, by clear corneal incision. Both ab externo and interno approaches can be performed combined with phacoemulsification. [ABSTRACT FROM AUTHOR]