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2 results on '"Mensah KA"'

1. Presentation and outcome of COVID-19 in HIV patients with high viral loads and opportunistic infections: a case series.

Author

Hardy YO, Amenuke DA, Hutton-Mensah KA, Chadwick DR, and Larsen-Reindorf R

Subjects
Adult, Africa South of the Sahara, COVID-19 complications, Coinfection complications, Female, HIV Infections complications, Humans, Male, Middle Aged, Opportunistic Infections complications, Viral Load, COVID-19 virology, Coinfection virology, HIV, HIV Infections virology, Opportunistic Infections virology, SARS-CoV-2
Abstract

Coronavirus disease 2019 (COVID-19) is especially severe in patients with underlying chronic conditions, with increased risk of mortality. There is concern that people living with HIV (PLWH), especially those with severe immunosuppression, and COVID-19 may have severe disease and a negative clinical outcome. Most studies on COVID-19 in PLWH are from Asia, Europe and America where population dynamics, antiretroviral treatment coverage and coexisting opportunistic infections may differ from that in sub-Saharan Africa. We report on the clinical profile and outcome of three cases of PLWH co-infected with SARS-CoV-2. They all presented with fever, cough and breathlessness and also had advanced HIV infection as evidenced by opportunistic infections, high HIV viral loads and low CD4 counts. The patients responded favourably to the standard of care and were discharged home. Our findings suggest that PLWH with advanced immunosuppression may not necessarily have an unfavourable disease course and outcome. However, case-controlled studies with a larger population size are needed to better understand the impact of COVID-19 in this patient population., Funding: Not declared., Competing Interests: Conflict of interest: None declared, (Copyright © The Author(s).)

Published
2020
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2. Clinical characteristics of males with systemic lupus erythematosus (SLE) in an inception cohort of patients in Ghana.

Author

Dey D, Ofori E, Hutton-Mensah KA, Akutek MLK, Okine R, Amoaba I, Agyemang-Duah K, and Kwarko H

Subjects
Adolescent, Adult, Ghana, Humans, Male, Middle Aged, Retrospective Studies, Severity of Illness Index, Sex Factors, Young Adult, Lupus Erythematosus, Systemic physiopathology, Lupus Nephritis physiopathology
Abstract

Background: Systemic Lupus Erythematosus (SLE) is said to be rare in Sub-Saharan Africa and even rarer in males worldwide. SLE is mostly considered a disease of women, though men may also be affected, and this may lead to a delay in diagnosis in men. The result is a greater burden of inflammation and subsequent organ damage over time., Method: Data from the medical records of 13 male patients diagnosed with SLE at the Rheumatology Clinic of Korle- Bu Teaching Hospital between January 2014 and January 2017 was retrospectively analyzed., Results: A total of 13 male patients out of a total of 134 SLE patients were included in our analysis. The mean age was 30.62 ± SD 8.47 years (range of 17 to 46 years). All of them (100%) presented with constitutional features. The most common ACR criteria observed was 61.5 % rash, 54.5 % oral ulcers, 92.3% arthritis, 61.5 % serositis and 38.5% renal involvement, 46.2 % CNS involvement. Looking at their serological profile, 91.7 % had a positive antinuclear antibody (ANA). 33.3 % had positive anti-dsDNA and 58.3 % extractable nuclear antigens. The mean duration from onset of symptoms to diagnosis was 21.31 months. Five patients were diagnosed with lupus nephritis, all at the time of diagnosis. There were no mortalities., Conclusion: Male SLE patients in Ghana are comparable to other populations, with arthritis and constitutional features being predominant early features and lupus nephritis being the main early indicator of organ damage. This should warrant aggressive management in male patients., Funding: None declared., Competing Interests: Conflict of interest: None declared

Published
2019
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