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Objective: Glioblastoma multiforme (GBM) WHO°IV is the most frequent and at the same time prognostically most unfavorable brain tumor with a heterogeneous appearance in MRI. Recent publications have shown that GBMs grouped into three phenotypically different subtypes are associated with significant [for full text, please go to the a.m. URL]

Objective: Tumor cell invasion has been demonstrated to be enhanced by inflammatory cytokines such as IL-17A, IL-22, IL-23 and CCL20 in various tumor entities other than glioblastoma (GBM). We have tested the impact of these factors on GBM migration and invasion utilizing four different in vitro techniques. [for full text, please go to the a.m. URL]

Objective: Planning is a crucial factor for successful treatment in neurosurgery. 3D visualization (3D) and virtual reality (VR) allows for superior image data presentation, condenses image information and accommodates our stereopsis habits. We developed a neurosurgical planning tool which allows 3D [for full text, please go to the a.m. URL]

Objective: The expression level of programmed cell death ligand 1 (PDL-1) might be an indicator for response to immunotherapy using checkpoint inhibitors in patients with non-small cell lung cancer (NSCLC). As intra-tumoral differences and discrepancies between the PDL-1 expression in the primary tumor [for full text, please go to the a.m. URL]

Objective: To specifically identify invasive glioblastoma (GBM) cells we used Laser Microdissection in GBM specimen acquired during 5-ALA supported resection. We addressed several obstacles to optimize the dissection protocol: a. stability of the Protoporphyin IX fluorescence after retrieval of the [for full text, please go to the a.m. URL]

Objective: Gliomagenesis is a highly relevant topic that has not yet been fully understood. Studies suggest that high-grade gliomas, such as GBMs, originally derive from neural precursor cells. There are two regions in the human brain containing large pools of neural stem cells, first the subventricular [for full text, please go to the a.m. URL]

Objective: Few cerebral aneurysms are not completely clippable or even unclippable due to small size and/or difficult morphology. In some cases, the aneurysm can be clipped partially and the remnant is wrapped with muscle, cotton and glue (clip-wrapping), or, the aneurysm is wrapped solely. In [for full text, please go to the a.m. URL], 72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie

Objective: Computation Fluid Dynamics (CFD) is a well established tool to investigate hemodynamics in vascular geometries. Various authors found correlations between specific CFD-parameters and intraoperatively thin-appearing aneurysm wall regions. Optical Coherence Tomography (OCT), providing tissue[for full text, please go to the a.m. URL], 72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie

Objective: Mapping language capacity with its subfunctions during direct cortical stimulation (DCS) in the stetting of awake craniotomy might be challenging without using more than one language paradigm. Applying several language tasks leads to increasing surgery times and to patient’s exhaustion.[for full text, please go to the a.m. URL], 72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie

Objective: Preceding studies found a main influence of the dentato-rubro-thalamic tract (DRTT) in the mechanisms of Essential Tremor. However, the influence of different parts of the DRTT, consisting of a ipsilateral and a decussating part, has not been investigated yet with respect to tremor reduction.[for full text, please go to the a.m. URL], 72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie

Objective: The aim of our study was to investigate which subcorticalfiber tracts and cortical areas are involved in the occurrence of side-effects in deep brain stimulation for Parkinson’s disease. Methods: 21 patients with Parkinson’s disease and bilaterally implanted electrodes [for full text, please go to the a.m. URL], 71. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 9. Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie

Objective: Hemodynamic parameters and the flow situation inside intracranial aneurysms have great influence on the risk of rupture. Therefore, computational fluid dynamics (CFD) is a frequently used tool for rupture risk assessment [ref:1]. However, there are great differences between different[for full text, please go to the a.m. URL], 71. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 9. Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie

Objective: A score combining Glasgow Coma Scale (GCS) and pupil response (GCS-P) as well as the Eppendorf-Köln Scale (ECS) have been introduced as novel trauma scores recently. This study aims to evaluate the prognostic value of these scores in aneurysmal subarachnoid hemorrhage (SAH). Methods:[for full text, please go to the a.m. URL], 70. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Skandinavischen Gesellschaft für Neurochirurgie

Objective: Intraventricular tumors represent a rare and challenging neurosurgical entity. Complete surgical resection is the treatment of choice, if feasible, for any tumor identity. Here, we report 97 patients with classical primary intraventricular tumors that underwent surgery at our institution.[for full text, please go to the a.m. URL], 70. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Skandinavischen Gesellschaft für Neurochirurgie

Objective: Molecular markers in glioma are essential for diagnosis, treatment and prognosis. Isocitrate-dehydrogenase 1/2 (IDH1/2) is one of the major diagnostic classifiers which plays a significant role in tumor metabolism. So far it is a postoperative immuno-histological or molecular diagnosis.[for full text, please go to the a.m. URL], 70. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Skandinavischen Gesellschaft für Neurochirurgie

Objective: The pathophysiology of delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage (aSAH) is still incompletely understood. Intrathecal inflammatory immune activation is suspected to play a major role for the induction of vasospasm and DCI. The aim of this study is to identify[for full text, please go to the a.m. URL], 70. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Skandinavischen Gesellschaft für Neurochirurgie

Objective: Aneurysmal subarachnoid haemorrhage (aSAH) remains a serious, life-threatening disease associated with high morbidity and mortality despite recent advances in neurocritical care as well as neurosurgical and endovascular treatment options. A multitude of pathological processes, such as inflammatory[for full text, please go to the a.m. URL], 70. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Skandinavischen Gesellschaft für Neurochirurgie

Objective: Thyroid dysfunction has been associated with aortic aneurysms and vascular dysfunction, however, there is limited data available on the prevalence of hypothyroidism in patients with aneurysmal subarachnoid hemorrhage (SAH). We hypothesized that the prevalence of hypothyroidism at admission[for full text, please go to the a.m. URL], 69. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Mexikanischen und Kolumbianischen Gesellschaft für Neurochirurgie

Objective: Mesenchymal stem cells (MSC) show an inherent brain tumor cell tropism that can be exploited for targeted delivery of therapeutic genes to invasive glioma. We assessed whether a motile stem cell-based local immunmodulation is able to overcome the immunosuppressive GBM microenvironment and[for full text, please go to the a.m. URL], 69. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Mexikanischen und Kolumbianischen Gesellschaft für Neurochirurgie

Objective: Intraventricular ependymal tumors in adults represent a rare and challenging neurosurgical entity. The role of radiotherapy is subject to controversial discussion and chemotherapy has shown to be ineffective, therefore complete surgical resection remains the treatment of choice, but scientific[for full text, please go to the a.m. URL], 68. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 7. Joint Meeting mit der Society of British Neurological Surgeons (SBNS)

Objective: The risk for intracranial aneurysms (IA) and aneurysmatic subarachnoid hemorrhage (SAH) is increased among patient’s family members, however, the genetic background of the disease is still poorly understood. Although large genome wide association studies identified several single nucleotide[for full text, please go to the a.m. URL], 68. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 7. Joint Meeting mit der Society of British Neurological Surgeons (SBNS)

Objective: According to ISUIA, cerebral aneurysms smaller than 7mm are believed to be associated with a low bleeding risk. However, other studies reported that a significant portion of ruptured aneurysms was smaller than 7 mm, which is in line with our clinical practice. The purpose of this study was[for full text, please go to the a.m. URL], 66. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)

Objective: The surgical management of lesions ventrally to the neuroaxis at the level of the craniovertebral junction (CVJ) and upper cervical spine is challenging. Here, we describe a minimal invasive dorsal approach for small ventrally located intradural lesions at the CVJ as an alternative for the[for full text, please go to the a.m. URL], 66. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)

Objective: Warning criteria for monitoring of motor evoked potentials (MEP) after direct cortical stimulation during surgery of supratentorial tumors have been well described. However, little is known about the value of MEP after transcranial electrical stimulation (TES) in predicting postoperative [for full text, please go to the a.m. URL], 66. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)

Objective: Pediatric patients constitute an unqiue subgroup of all cerebral AVM cases. Management of pediatric AVMs requires profound knowledge regarding the natural history of the lesion as well as associated treatment risks. Identification of children with AVMs that are more prone to bleed provides[for full text, please go to the a.m. URL], 64. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)

Objective: Subarachnoid hemorrhage (SAH) is still associated with high morbidity and mortality. Therefore, specialized neurointensive care is desirable in the acute stage in order to prevent major clinical impairment in the critical first hours post-injury. Our objective was to evaluate the clinical[for full text, please go to the a.m. URL], 64. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)

Objective: This study evaluates the clinical results and quality of life (QoL) after surgical treatment for trigeminal neuralgia (TN) in patients over 70 years. Methods: A total of 96 TN-patients were treated between 1998–2009 in which microvascular decompression (MVD) or percutaneous electrocoagulation[for full text, please go to the a.m. URL], 61. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC) im Rahmen der Neurowoche 2010