1. Paeciloside A, a new antimicrobial and cytotoxic polyketide from Paecilomyces sp. strain CAFT156.
- Author
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Talontsi FM, Nwemeguela Kenla TJ, Dittrich B, Douanla-Meli C, and Laatsch H
- Subjects
- Animals, Annonaceae microbiology, Anti-Infective Agents chemistry, Anti-Infective Agents pharmacology, Artemia drug effects, Bacillus subtilis drug effects, Biological Products chemistry, Biological Products pharmacology, Copper chemistry, Fermentation, Indoles isolation & purification, Indoles pharmacology, Larva drug effects, Magnetic Resonance Spectroscopy, Molecular Conformation, Mucor drug effects, Paecilomyces growth & development, Plant Leaves microbiology, Polyketides chemistry, Polyketides pharmacology, Pyridones isolation & purification, Pyridones pharmacology, Staphylococcus aureus drug effects, X-Ray Diffraction, Anti-Infective Agents isolation & purification, Paecilomyces chemistry, Polyketides isolation & purification
- Abstract
Paeciloside A (1) and eight known compounds, acremoauxin A (2), farinosones A (3) and B (4), 1,5-dideoxy-3-C-methyl-arabitol (5), ergosterol, ergosterol peroxide, cerebroside C, and adenosine, were isolated from cultures of Paecilomyces sp. CAFT156, an endophytic fungus occurring in Enantia chlorantha Oliv (Annonaceae) leaves. The structure of the new compound 1 was elucidated using MS, UV, 1D and 2D NMR experiments, while its absolute configuration was established by subsequent single-crystal X-ray diffraction analysis using copper Kα radiation and invariom nonspherical scattering factors. Paeciloside A (1) and compounds 2, 4, and 5 displayed inhibitory effects on two gram-positive bacteria, Bacillus subtilis and Staphylococcus aureus at a concentration of 40 µg per paper disk and moderate cytotoxicity towards brine shrimp larvae (Artemia salina). This study presents the first report on an endophytic fungus isolated from E. chlorantha Oliv and its natural products., (Georg Thieme Verlag KG Stuttgart · New York.)
- Published
- 2012
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