1. Geranyl dihydrochalcones from Artocarpus altilis and their antiausteric activity.
- Author
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Nguyen MT, Nguyen NT, Nguyen KD, Dau HT, Nguyen HX, Dang PH, Le TM, Nguyen Phan TH, Tran AH, Nguyen BD, Ueda JY, and Awale S
- Subjects
- Cell Line, Tumor, Cytotoxins chemistry, Cytotoxins isolation & purification, Humans, Nuclear Magnetic Resonance, Biomolecular, Pancreatic Neoplasms pathology, Phytotherapy, Plant Extracts chemistry, Plant Extracts isolation & purification, Tumor Microenvironment, Artocarpus chemistry, Chalcones pharmacology, Cytotoxins pharmacology, Plant Extracts pharmacology
- Abstract
Human pancreatic cancer cell lines have remarkable tolerance to nutrition starvation, which enables them to survive under a tumor microenvironment. The search for agents that preferentially inhibit the survival of cancer cells under low nutrient conditions is a novel antiausterity strategy in anticancer drug discovery. In this study, the methanolic extract of the leaves of Artocarpus altilis showed 100 % preferential cytotoxicity against PANC-1 human pancreatic cancer cells under nutrient-deprived conditions at a concentration of 50 µg/mL. Further investigation of this extract led to the isolation of eight new geranylated dihydrochalcones named sakenins A-H (1-8) together with four known compounds (9-12). Among them, sakenins F (6) and H (8) were identified as potent preferentially cytotoxic candidates with PC50 values of 8.0 µM and 11.1 µM, respectively., (Georg Thieme Verlag KG Stuttgart · New York.)
- Published
- 2014
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