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This article presents the findings of a multi-center study conducted in Italy that aimed to assess the frequency of type I gastric neuroendocrine neoplasms (gNENs) in patients with autoimmune atrophic gastritis (AAG). The study included 375 patients with AAG, and over a median follow-up of 4 years, 80 patients were found to have 97 well-differentiated gNENs. The study highlights the importance of regular endoscopic surveillance and thorough histopathological examination in patients with AAG for early diagnosis and treatment of gNENs. The occurrence of gNENs in patients with AAG is linked to elevated circulating gastrin levels, which stimulate abnormal proliferation of gastric enterochromaffin-like cells. [Extracted from the article]

This article presents the findings of a multicentric retrospective study conducted in Italy on patients with autoimmune atrophic gastritis (AAG). The study aimed to investigate the incidence and characteristics of gastric polyps in patients with AAG. The study included 375 patients with AAG, and it was found that 50.4% of these patients had at least one incidental polyp. The polyps observed included inflammatory, adenomatous, fundic gland polyps, gastric neuroendocrine tumors (gNETs), adenocarcinomas, and one MALT lymphoma. The study highlights the importance of proactive endoscopic monitoring and comprehensive histopathological evaluation in patients with AAG to effectively identify and manage these different gastric lesions. [Extracted from the article]