1. 4-(Isoxazol-3-yl)pyrimidines from Pyrimidinyl Nitrile Oxides
- Author
-
Thomas C. Sparks, James Ruiz, Lorsbach Beth, Mark J. Kurth, and Wonken Choung
- Subjects
chemistry.chemical_compound ,Nitrile ,Chemistry ,Organic Chemistry ,Combinatorial chemistry ,PubChem ,Cycloaddition - Abstract
The 1,3-dipolar cycloaddition reaction of pyrimidinyl aldoxime derived nitrile oxides and alkynes delivers 4-(isoxazol-3-yl)pyrimidines. The procedures reported accommodate three points of diversification around this bisheterocyclic scaffold and the resulting library of compounds has been added to the National Institutes of Health repository (ca. 10 mg of each with >90% purity) for pilot-scale biomedical studies with bioassay data available at the National Center for Biotechnology Information PubChem database.
- Published
- 2008