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51 results on '"Ulrike Protzer"'

1. S3-Leitlinie der Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS) zur Prophylaxe, Diagnostik und Therapie der Hepatitis-B-Virusinfektion – (AWMF-Register-Nr. 021-11)

Author

Stefan Wirth, Frank Tacke, Pia van Leeuwen, Claus Niederau, Dieter Glebe, Heiner Wedemeyer, P. Lynen-Jansen, Markus Cornberg, Ulrike Protzer, Thomas Berg, Lisa Sandmann, Jörg Petersen, W. Jilg, Christoph Höner zu Siederdissen, and CiiM, Zentrum für individualisierte Infektionsmedizin, Feodor-Lynen-Str.7, 30625 Hannover.

Subjects
Gynecology, Hepatitis B virus, medicine.medical_specialty, business.industry, Gastroenterology, Medicine, Hepatitis B, business, medicine.disease_cause, medicine.disease
Abstract

[No abstract available]

Published
2021

3. Oxygenation and miR138-5 p act as rheostats in APOBEC3B-mediated Hepatitis B Virus control

Author

Julie Lucifora, Sandra Prokosch, Martha Schneider, Suzanne Faure-Dupuy, Emmanuel Dejardin, Katharina Neuhaus, Florian Reisinger, M Stadler, David Durantel, Romain Barnault, Jane A. McKeating, Kristian Unger, Z Hizir, Romain Parent, Tobias Riedl, Daniel B. Lipka, Jochen M. Wettengel, Mathias Heikenwalder, Ulrike Protzer, Rayan Farhat, B Stottmeier, Xiaodong Zhuang, M Schönung, and Peter Schirmacher

Subjects
Hepatitis B virus, business.industry, Medicine, Oxygenation, business, medicine.disease_cause, Virology
Published
2020

4. A dual role for hepatocyte-intrinsic canonical NF-κB signaling in virus control

Author

Ulrike Protzer, Percy A. Knolle, P Stäheli, Daniela Lenggenhager, Sukumar Namineni, F Li, Pa Lang, Zeinab Abdullah, Andreas Muschaweckh, Dirk Wohlleber, Emmanuel Dejardin, Michael Karin, Tobias Riedl, Sandra Lampl, K Liu, Kai Breuhahn, Pål Johansen, Tracy O'Connor, Bernhard Holzmann, Prashant V. Shinde, Mathias Heikenwalder, Marc Ringelhan, Julie Lucifora, Rayan Farhat, Achim Weber, Patrick Blank, Suzanne Faure-Dupuy, Ulrich Kalinke, H Xu, Indrabahadur Singh, David Durantel, Marco Binder, Katharina Borst, Thomas M. Kündig, Karl S. Lang, Aleksandra A. Pandyra, Maude Rolland, and Piyush Sharma

Subjects
Nf κb signaling, medicine.anatomical_structure, Dual role, Chemistry, Hepatocyte, medicine, Virus, Cell biology
Published
2020

5. Hepatitis B virus escapes non-canonical CTL effector function

Author

Katja Steiger, Percy A. Knolle, Ulrike Protzer, Dirk Wohlleber, and K. Sandra

Subjects
Hepatitis B virus, CTL, Hepatology, Non canonical, Effector, Gastroenterology, medicine, Biology, medicine.disease_cause, Virology, Function (biology)
Published
2018

9. T-Cell Receptor Grafting allows Control of Hepatitis B Virus Infection

Author

Marc Lütgehetmann, Stephan Urban, Antje Malo, Karin Wisskirchen, Tassilo Volz, Tanja Bauer, Lena Allweiss, Theresa Asen, J Kah, Jochen M. Wettengel, Maura Dandri, and Ulrike Protzer

Subjects
Hepatitis B virus, T-cell receptor, medicine, Biology, medicine.disease_cause, Grafting, Virology
Published
2019

11. HDVdb: Hepatitis D virus database

Author

Dmitrij Frishman, Hadi Karimzadeh, Michael Roggendorf, Zainab Usman, and Ulrike Protzer

Subjects
business.industry, Medicine, Hepatitis D virus, business, Virology
Published
2019

12. Viral escape contributes to the failure of hepatitis D virus (HDV)-specific CD8+ T cells and drives population-level evolution of HDV

Author

J Schulze zur Wiesch, Maria Buti, E Salimi Alizei, M. Kiraithe, Jörg Timm, JH Bockmann, Robert Thimme, Michael Roggendorf, Francisco Rodriguez-Frias, Bijan Raziorrouh, Ulrike Protzer, Marcus Panning, Andreas Heinold, Maike Hofmann, Rosario Casillas, Antonina Smedile, Seyed Moayed Alavian, Bettina Budeus, Heiner Wedemeyer, Emma Gostick, Daniel Hoffmann, Valerie Oberhardt, David Price, Florian Emmerich, Christoph Neumann-Haefelin, and Hadi Karimzadeh

Subjects
Population level, Cytotoxic T cell, Hepatitis D virus, Biology, Virology
Published
2019

14. Prophylaxis, diagnosis and therapy of Hepatitis C Virus (HCV) infection : The German guidelines on the management of HCV infection

Author

Wolfgang Vogel, Ulrike Protzer, Harald H. Kessler, M.P. Manns, Markus H. Heim, Hartmut Schmidt, Stefan Zeuzem, Stefan Wirth, H. Wedemeyer, Wolfgang E. Fleig, P. Ferenci, Ulrich Spengler, Markus Cornberg, Christoph Sarrazin, Matthias M. Dollinger, R. S. Ross, Markus Peck-Radosavljevic, Ulf P. Neumann, Darius Moradpour, Thomas Berg, and Peter Schirmacher

Subjects
business.industry, Hepatitis C virus, Medizin, Gastroenterology, Drug resistance, Hepatitis C, Hepatitis B, medicine.disease, medicine.disease_cause, Hepatitis D, Virology, Transplantation, 03 medical and health sciences, 0302 clinical medicine, Pharmacotherapy, medicine, 030211 gastroenterology & hepatology, 030212 general & internal medicine, Viral hepatitis, business
Published
2010

16. Kurzfassung der aktualisierten S3-Leitlinie 'Diagnostik und Therapie der Hepatitis B'

Author

M. Cornberg, Thomas Berg, Matthias M. Dollinger, Ulrike Protzer, and Heiner Wedemeyer

Subjects
Hepatitis B virus, medicine.medical_specialty, business.industry, medicine.drug_class, Viremia, General Medicine, Hepatitis B, medicine.disease_cause, medicine.disease, Natural history, Critical level, Internal medicine, Immunology, medicine, Antiviral drug, business, Viral hepatitis, Pediatric gastroenterology
Abstract

Therapeutic option for hepatitis B virus infection have significantly improved in recent years. Moreover, new insights in the natural history of hepatitis B required an update of current national guidelines. Therefore, the German network of competence on viral hepatitis (Hep-Net) has revised guidelines on diagnosis and treatment og HBV incetion in cooperation with the national societies for Gastroenterology, Pathology, Virology, and Pediatric Gastroenterology. Important alterations concern the indication for antiviral therapy considering an HBV viremia of 104 copies/ml (2000 IU/ml) as a critical level. Moreover, specific recommendations how to prevent and to treat antiviral drug resistance are given. Finally, the importance of HBV in the context of organ and bone marrow transplantation, treatment of coinfections and children and prophylaxis of HBV is covered.

Published
2007

17. Prophylaxe, Diagnostik und Therapie der Hepatitis-B-Virus-(HBV-)Infektion: 'Upgrade' der Leitlinie, AWMF-Register-Nr.: 021/011

Author

Wolfgang E. Fleig, Thomas Berg, H. Wedemeyer, Peter Schirmacher, Ulrike Protzer, M. Cornberg, Andreas Erhardt, M.P. Manns, Stefan Wirth, Matthias M. Dollinger, Wolfgang Jilg, and Jörg Petersen

Subjects
medicine.medical_specialty, business.industry, Carrier state, medicine.medical_treatment, Gastroenterology, Guideline, Liver transplantation, Hepatitis B, medicine.disease, Pharmacotherapy, Internal medicine, Hepatitis B virus HBV, Medicine, business, Intensive care medicine
Published
2007

22. Bispecific antibody constructs mediate immunotherapeutic retargeting of effector cells towards HBV infected target cells

Author

Ulrike Protzer, Oliver Quitt, Frank Momburg, Gerhard Moldenhauer, Julia Hasreiter, Felix Bohne, and Volker Bruss

Subjects
Bispecific antibody, Liver disease, Chronic hepatitis, Effector, Hepatocellular carcinoma, Retargeting, Gastroenterology, medicine, Biology, Viral hepatitis, medicine.disease, Virology
Abstract

Chronic viral hepatitis is a major public health threat. Currently, strategies to eradicate the viruses and treatments for virus-induced liver disease and hepatocellular carcinoma are very limited. Novel therapeutic strategies are in urgent need. The immunotherapeutic retargeting of effector cells is a promising approach to circumvent the immunotolerant state found in malignancies and chronic viral infections. In this webinar, Dr. Bohne will present his latest work on how xCELLigence RTCA technology in conjunction with other cellular/molecular tools were utilized in the discovery of the bispecific antibody constructs as a promising new immunetherapeutic approach against chronic Hepatitis B.

Published
2015

25. T cells redirected by a chimeric antigen receptor efficiently control Hepatitis B Virus replication in an immunocompetent mouse model

Author

Felix Bohne, Ulrike Protzer, Hinrich Abken, Silke Arzberger, N. Böttinger, Markus Chmielewski, Michaela Aichler, Mathias Heikenwalder, Percy A. Knolle, Li-Rung Huang, Georg Gasteiger, K Krebs, and Wolfgang Uckert

Subjects
Hepatitis B virus, Replication (statistics), Gastroenterology, medicine, Biology, medicine.disease_cause, Virology, Chimeric antigen receptor, Immunocompetent mouse
Published
2014

27. Verlaufskontrolle des Morbus Crohn: Kann die Hydro-MRT die fraktionierte Magen-Darm-Passage ersetzen?

Author

S. Schadmand-Fischer, Ulrike Protzer, Manfred Thelen, Metzmann U, K.-F. Kreitner, K. Schunk, R. Wanitschke, Rainer Duchmann, and Kersjes W

Subjects
Crohn's disease, medicine.medical_specialty, medicine.diagnostic_test, business.industry, medicine.medical_treatment, Ileum, Magnetic resonance imaging, Enema, Disease, medicine.disease, Gastroenterology, Surgery, Barium sulfate, chemistry.chemical_compound, medicine.anatomical_structure, chemistry, Internal medicine, medicine, Upper gastrointestinal, Radiology, Nuclear Medicine and imaging, business, Peristalsis
Abstract

PURPOSE: To compare the value of hydro-MRI with follow-through examinations in the follow-up of Crohn's disease. METHOD: 22 patients known to be suffering from Crohn's disease were examined via 1.5 T-MR system; an oral contrast examination using 1000 ml of a 2.5% mannitol solution was performed in all patients. T2-weighted TSE sequences and T1-weighted SE sequences were performed before and after the intravenous injection of Gd-DTPA. To reduce movement artifacts caused by peristalsis of the gut, intravenous injection of 40 mg Buscopan was given. The findings of hydro-MRI were compared with the follow-through examinations. RESULTS: In the upper gastrointestinal tract, the follow-through examination showed clear advantages compared with hydro-MRI for the demonstration of inflammatory changes in the gut; Hydro-MRI was, however, somewhat more reliable in the ileum and colon. It was also more sensitive than the follow-through for the demonstration of enteric fistulae (four as compared with two cases), and in demonstration extraluminal changes (free fluid in six against zero, and inflammatory adherent loops (four against zero)). Amongst the 22 patients, hydro-MRI was equal (in 10) or better (in 8) than the follow-through examination for demonstrating the intestinal manifestations of Crohn's disease, and follow-through was better in only four. CONCLUSION: For follow-up of Crohn's disease, hydro-MRI is at least as good as follow-through examination, and is even preferable, because of the absence of radiation exposure of the usually young patients.

Published
1997

34. A novel non-MHC-I restricted CTL effector function mediated by TNF and XIAP

Author

Margarete Odenthal, K. Gärtner, Hans-Peter Dienes, Christian Kurts, Günter J. Hämmerling, Ulrike Protzer, Percy A. Knolle, D Stabenow, Martin Krönke, and Bernd Arnold

Subjects
biology, Effector, Gastroenterology, Cross-presentation, medicine.disease, XIAP, CTL, MHC class I, Immunology, biology.protein, medicine, Tumor necrosis factor alpha, Viral hepatitis, Function (biology)
Published
2011

37. Multi kinase inhibitor Sorafenib modulates cytokine secretion by HCC and liver tissue

Author

Peter Büchler, Helmut Friess, Gerd Otto, Michael Heise, Martin F. Sprinzl, M. Schuchmann, Peter R. Galle, Arndt Weinmann, and Ulrike Protzer

Subjects
Sorafenib, business.industry, Kinase, Gastroenterology, Inflammation, medicine.disease, Hepatocellular carcinoma, Liver tissue, Cancer research, Medicine, Cytokine secretion, medicine.symptom, business, medicine.drug
Published
2011

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