1. Efficacy of platelet-rich plasma as a shielding technique after endoscopic mucosal resection in rat and porcine models
- Author
-
Vicente Lorenzo-Zúñiga, Jaume Boix, Vicente Moreno de Vega, Ignacio Bon, Ingrid Marín, and Ramón Bartolí
- Subjects
Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Background and study aims: The aims were to assess the efficacy of endoscopic application of Platelet-rich plasma (PRP) to prevent delayed perforation and to induce mucosal healing after endoscopic resections. Patients and methods: Colonic induced lesions were performed in rats (n = 16) and pigs (n = 4). Animals were randomized to receive onto the lesions saline (control) or PRP. Animals underwent endoscopic follow-up. Thermal injury was assessed with a 1 – 4 scale: (1) mucosal necrosis; (2) submucosal necrosis; (3) muscularis propria necrosis; and (4) serosal necrosis Results: Saline treatment showed 50 % of mortality in rats (P = 0.02). Mean ulcerated area after 48 hours and 7 days was significantly smaller with PRP than with saline (0.27 ± 0.02 cm2 and 0.08 ± 0.01 cm2 vs. 0.56 ± 0.1 cm2 and 0.40 ± 0.06 cm2; P
- Published
- 2016
- Full Text
- View/download PDF