1. Nucleophilic 18F-Fluorination of Anilines via N-Arylsydnone Intermediates
- Author
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Kendall N. Houk, Pier Alexandre Champagne, Maruthi Kumar Narayanam, Gaoyuan Ma, and Jennifer M. Murphy
- Subjects
chemistry.chemical_compound ,Nucleophile ,chemistry ,010405 organic chemistry ,Organic Chemistry ,Bioorthogonal chemistry ,010402 general chemistry ,Sydnone ,01 natural sciences ,Combinatorial chemistry ,0104 chemical sciences - Abstract
Preparation of [18F]fluoroarenes with nucleophilic [18F]fluoride for positron emission tomography (PET) molecular imaging research is a challenging chemical endeavor. Advances in radiofluorination have soared in the last decade, broadening the availability of potential [18F]fluoroarenes. In this Synpacts article, we highlight the recent development from our laboratory of a practical radiofluorination of anilines via N-arylsydnone intermediates to afford [18F]fluoroarenes. Further, we emphasize the utility of this methodology towards peptide labeling applications by preparing an 18F-labeled neuropeptide.1 Introduction2 Nucleophilic Radiofluorination of N-Arylsydnones3 Substrate Scope and Applications4 Conclusion
- Published
- 2018
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