1. Antitumor Components Isolated from the Chinese Herbal MedicineCoix lachryma-jobi
- Author
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Hiromi Yamada, Atsuko Moribayashi, Mitsuhiro Numata, and Akihiko Yamamoto
- Subjects
Pharmaceutical Science ,Fraction (chemistry) ,Fatty Acids, Nonesterified ,Analytical Chemistry ,Mice ,chemistry.chemical_compound ,Column chromatography ,In vivo ,Drug Discovery ,Acetone ,Animals ,Coix ,Pharmacology ,Mice, Inbred ICR ,Aqueous solution ,biology ,Traditional medicine ,Silica gel ,Organic Chemistry ,food and beverages ,biology.organism_classification ,Antineoplastic Agents, Phytogenic ,Complementary and alternative medicine ,chemistry ,Seeds ,Molecular Medicine ,Female ,Drug Screening Assays, Antitumor ,Growth inhibition ,Drugs, Chinese Herbal - Abstract
The seeds of the gramineous plant Coix lachryma-jobi L. var. ma-yuen Stapf are a traditional Chinese medicine possessing antitumor activity. An acetone extract of the seeds was fractionated by the aqueous alkali method and by silica gel column chromatography in order to identify the antitumor components. Antitumor activity, as assayed by an in vivo growth inhibition test on a transplantable mouse tumor, was attributed to an acidic fraction. Infrared spectroscopy and gas-liquid chromatography showed that this acidic fraction was composed of four free fatty acids: palmitic, stearic, oleic, and linoleic acids.
- Published
- 1994
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