1. Maternal Age at Delivery and Enzyme Polymorphisms in Children with Type 1 Diabetes Mellitus
- Author
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Novella Rapini, Gabriele Renzetti, Egidio Bottini, Andrea Magrini, Patrizia Saccucci, Anna Neri, Fulvia Gloria-Bottini, and Maria Luisa Manca Bitti
- Subjects
endocrine system diseases ,Physiology ,030209 endocrinology & metabolism ,Locus (genetics) ,PTPN22 ,03 medical and health sciences ,0302 clinical medicine ,immune system diseases ,Genotype ,Medicine ,Advanced maternal age ,Gene ,chemistry.chemical_classification ,Fetus ,Type 1 diabetes ,business.industry ,nutritional and metabolic diseases ,medicine.disease ,Settore MED/44 ,p53 codon 72 ,Enzyme ,chemistry ,maternal age ,030220 oncology & carcinogenesis ,Pediatrics, Perinatology and Child Health ,Surgery ,ACP1 ,business ,type 1 diabetes mellitus - Abstract
Fetal genetic adaptation to environment of aging women could result in positive selection of genes that during extrauterine life increases the risk of type 1 diabetes mellitus (T1DM). We have examined the distribution of three genetic polymorphisms (acid phosphatase locus 1 [ACP1], p53 codon 72, and PTPN22) involved in T1DM risk in relation to maternal age at delivery. p53 codon 72 was determined in 281 T1DM children, ACP1 in 207 children, and PTPN22 in 216 children. Controls (blood donors) were 351 for ACP1, 271 for PTPN22, and 730 for p53 codon 72. Genotypes were determined by DNA analysis. The proportions of the three genotypes associated with T1DM are much greater in T1DM children from older mothers than in those from young mothers and in controls. The data support the hypothesis that advanced maternal age favors a positive selection of genes more adapted to the uterine environment of older women: these genes predispose to T1DM during extrauterine life.
- Published
- 2018
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