1. Cerebral Oxygenation, Vascular Reactivity, and Biochemistry following Decompressive Craniectomy for Traumatic Brain Injury
- Author
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Ivan Ng, Kah Keow Lee, Christopher B. T. Ang, and Chi Long Ho
- Subjects
medicine.medical_specialty ,business.industry ,Traumatic brain injury ,medicine.medical_treatment ,Glasgow Coma Scale ,Ischemia ,Oxygenation ,medicine.disease ,Surgery ,Refractory ,Anesthesia ,Intensive care ,Medicine ,Decompressive craniectomy ,Neurochemistry ,Neurology (clinical) ,business - Abstract
Object: This study addresses the changes in brain oxygenation, cerebrovascular reactivity, and cerebral neurochemistry following decompressive craniectomy for the control of raised intracranial pressure following severe head injury. Methods: Over 1 year, 16 consecutive patients with raised intracranial pressure (ICP) refractory to maximal medical therapy underwent decompressive craniectomy. The 13 male and 3 female patients had a mean age of 38 and a median admission Glasgow Coma Score (GCS) of 5. Six months following traumatic brain injury (TBI), 11 patients had a poor outcome (group 1; Glasgow Outcome Score 1 to 3) while the remaining 5 patients had a favorable outcome (group 2; Glasgow Outcome Score 4 to 5). Decompressive craniectomy resulted in a significant fall in mean ICP in both groups of patients (25 mmHg to 18 mmHg in group 1 and 18 mmHg to 13 mmHg in group 2) while the mean PRx returned to normal values (
- Published
- 2007