Search

Your search keyword '"Guang-Zhong Tu"' showing total 2 results
Start Over Author "Guang-Zhong Tu" Publisher georg thieme verlag kg
2 results on '"Guang-Zhong Tu"'

2. Synthesis of AZT/d4T Boranophosphates as Anti-HIV Prodrug Candidates

Author

Yufen Zhao, Guang-Zhong Tu, Hua Fu, and Changxue Lin

Subjects
Boranophosphate, Silylation, Chemistry, Anti hiv, viruses, Organic Chemistry, virus diseases, biochemical phenomena, metabolism, and nutrition, Prodrug, Phosphonate, Catalysis, chemistry.chemical_compound, Ammonium hydroxide, Hydrolysis, parasitic diseases, Pivaloyl chloride, Organic chemistry, heterocyclic compounds
Abstract

AZT/d4T phosphonates were synthesized by sequential condensation of AZT/d4T with the corresponding alcohols or 5'-DMT-thymidine in the presence of pivaloyl chloride. Sequential silylation, boronation, and hydrolysis in ammonium hydroxide of these phosphonates led to anti-HIV prodrug candidates AZT/d4T boranophosphates.

Published
2004

Catalog

Books, media, physical & digital resources
See catalog results