1. Neuroprotective potential of Ginkgo biloba in retinal diseases
- Author
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Isabel Martínez-Solís, Victoria Villagrasa, Francisco Bosch-Morell, Dolores Muñoz-Mingarro, Maria A. Sanahuja, Nuria Acero, María Eugenia González-Rosende, Encarna Castillo, T. Ortega, UCH. Departamento de Ciencias Biomédicas, UCH. Departamento de Farmacia, and Producción Científica UCH 2019
- Subjects
Ginkgo biloba - Uso terapéutico ,Pharmaceutical Science ,Pharmacology ,medicine.disease_cause ,01 natural sciences ,Neuroprotection ,Analytical Chemistry ,chemistry.chemical_compound ,Retinal Diseases ,Ginkgo biloba - Therapeutic use ,Drug Discovery ,Animals ,Humans ,Medicine ,Retina ,biology ,Plant Extracts ,010405 organic chemistry ,business.industry ,Ginkgo biloba ,Retina - Diseases - Treatment ,System nervous - Degeneration - Treatment ,Organic Chemistry ,Neurodegeneration ,Neurodegenerative Diseases ,Retinal ,Diabetic retinopathy ,Macular degeneration ,medicine.disease ,biology.organism_classification ,Eye - Diseases - Treatment ,0104 chemical sciences ,Sistema nervioso - Degeneración - Tratamiento ,010404 medicinal & biomolecular chemistry ,Neuroprotective Agents ,medicine.anatomical_structure ,Complementary and alternative medicine ,chemistry ,Ojos - Enfermedades - Tratamiento ,Molecular Medicine ,business ,Oxidative stress ,Phytotherapy ,Retina - Enfermedades - Tratamiento - Abstract
Like other tissues of the central nervous system, the retina is susceptible to damage by oxidative processes that result in several neurodegenerative disease such as age-related macular degeneration, diabetic retinopathy, glaucoma, ischaemic retinal disease, retinal disease produced by light oxidation, and detached retina, among other diseases. The use of antioxidant substances is a solution to some health problems caused by oxidative stress, because they regulate redox homeostasis and reduce oxidative stress. This is important for neurodegeneration linked to oxidation processes. In line with this, Ginkgo biloba is a medicinal plant with excellent antioxidant properties whose effects have been demonstrated in several degenerative processes, including retinal diseases associated with neurodegeneration. This review describes the current literature on the role of ginkgo in retinal diseases associated with neurodegeneration. The information leads to the conclusion that G. biloba extracts might be a good option to improve certain neurodegenerative retinal diseases, but more research is needed to determine the safety and efficacy of G. biloba in these retinal degenerative processes.
- Published
- 2019