Search

Your search keyword '"Dietel, M"' showing total 37 results
Start Over Author "Dietel, M" Publisher georg thieme verlag kg
37 results on '"Dietel, M"'

1. Evolutionary distance predicts recurrence after liver transplantation in multifocal hepatocellular carcinoma

Author

Heits, N, additional, Brosch, M, additional, Herrmann, A, additional, Behrens, R, additional, Röcken, C, additional, Schrem, H, additional, Kaltenborn, A, additional, Klempnauer, J, additional, Kreipe, H, additional, Reichert, B, additional, Lenschow, C, additional, Wilms, C, additional, Wolters, H, additional, Wardelmann, E, additional, Seehofer, D, additional, Buch, S, additional, Zeissig, S, additional, Pannach, S, additional, Raschzok, N, additional, Dietel, M, additional, Schoenfels, W, additional, Hinz, S, additional, Teufel, A, additional, Evert, M, additional, Franke, A, additional, Becker, T, additional, Braun, F, additional, Hampe, J, additional, and Schafmayer, C, additional

Published
2018
Full Text
View/download PDF

2. Endocrine Markers in Malignant Tumor Cells Producing Parathyroid Hormone-Related Protein

Author

Zabel M and Dietel M

Subjects
Adenoma, Calcitonin, musculoskeletal diseases, Endocrinology, Diabetes and Metabolism, Synaptophysin, Enteroendocrine cell, Peptide hormone, Biology, Immunoenzyme Techniques, Endocrinology, Neoplasms, Endocrine Gland Neoplasms, Biomarkers, Tumor, Chromogranins, Tumor Cells, Cultured, Internal Medicine, Humans, Endocrine system, Thyroid Neoplasms, Parathyroid hormone-related protein, S100 Proteins, Parathyroid Hormone-Related Protein, Chromogranin A, General Medicine, Parathyroid chief cell, Parathyroid Neoplasms, Carcinoma, Medullary, Phosphopyruvate Hydratase, Protein Biosynthesis, Hypercalcemia, Cancer research, biology.protein, hormones, hormone substitutes, and hormone antagonists, Endocrine gland
Abstract

Humoral hypercalcemia of malignancy may reflect the synthesis and secretion of biologically active parathyroid hormone-related protein (PTHrP) by a given tumor. In the present study we investigated 25 human non-endocrine carcinomas which were clinically associated with hypercalcemia (Ca > 11 mg%). By applying PTHrP-specific immunocytochemistry, PTHrP could be detected in all tumors. The intra-tumorous distribution was heterogeneous with strong positivity in relatively few cells or weak positivity in the majority of cells. Surprisingly, in the PTHrP producing cells none of the marker proteins typical of endocrine cells (neuron-specific enolase, Leu-7 antigen, chromogranin, synaptophysin and endocrine granule constituent) was found. On the other hand, PTHrP producing cells of endocrine origin, such as medullary cancer, or normal and adenomatous parathyroid glands, all produce these endocrine markers. Thus for the first time, the existence of peptide hormone producing tumor cells is reported without expression of endocrine markers. This indicates a special mechanism of PTHrP secretion.

Published
2009

3. ALK-Diagnostics in non-small cell Lung Cancer (NSCLC) - Immunohistochemistry (IHC) and/or Fluorescence-in-situ Hybridisation (FISH)? Statement of the German Society for Pathology and the WG Thoracic Oncology of the Working Group Oncology/German Cancer Society e.V.

Author

von Laffert, M., Schirmacher, P., Warth, A., Weichert, W., Buettner, R., Huber, R. M., Wolf, J., Griesinger, F., Dietel, M., Grohe, Ch., von Laffert, M., Schirmacher, P., Warth, A., Weichert, W., Buettner, R., Huber, R. M., Wolf, J., Griesinger, F., Dietel, M., and Grohe, Ch.

Abstract

The EML4-ALK pathway plays an important role in a significant subset of non-small cell lung cancer patients. Treatment options such as tyrosine kinase inhibitors directed against the EML4-ALK signalling pathway lead to improved progression free and overall survival. These therapeutic options are chosen on the basis of the identification of the underlying genetic signature of the EMLALK translocation. Efficient and easily accessible testing tools are required to identify the patients in time. While FISH techniques have been implemented to characterize this translocation for some time, the implementation of this testing is hampered by its broad use of resources. Immunohistochemical techniques to identify and screen for EML4-ALK translocations may play an important role in the near future. This consensus paper offers recommendations of the sequence and quality of the respective test approaches which are validated on the basis of the current literature.

Published
2016

4. HER2 testing in gastric cancer - results of a German expert meeting

Author

Lordick, F., Al-Batran, S. E., Hofheinz, R. D., Lorenzen, S., Thuss-Patience, P., Baretton, G. B., Dietel, M., Gaiser, T., Kirchner, T., Kreipe, H. H., Quaas, A., Roecken, C., Rueschoff, J., Tannapfel, A., Lordick, F., Al-Batran, S. E., Hofheinz, R. D., Lorenzen, S., Thuss-Patience, P., Baretton, G. B., Dietel, M., Gaiser, T., Kirchner, T., Kreipe, H. H., Quaas, A., Roecken, C., Rueschoff, J., and Tannapfel, A.

Abstract

Valid HER2 testing is essential for optimal therapy of patients with HER2 positive gastric cancer and the correct use of first-line treatment. While each breast cancer is routinely being tested for the HER2 status, HER2 testing in gastric cancer has still not become part of the routine and is often only done upon request by the therapist. An interdisciplinary German expert group took the challenges of HER2 testing in gastric cancer as an opportunity to address essential aspects and questions for the practical use of HER2 testing in this indication from the perspective of pathologists and therapists. The recommendations made in this manuscript reflect the consensus of all participants and correspond to their opinions and long-term experience.

Published
2016

5. Gesundheitstelematik/Telemedizin in der Republik Estland

Author

Parwis Fotuhi, Dietel M, Asser T, Gert Baumann, Friedrich Köhler, Schierbaum C, and Lange M

Subjects
Service (business), Telemedicine, business.industry, media_common.quotation_subject, Information technology, General Medicine, BITNET, Public administration, Estonian, language.human_language, Excellence, Political science, Information technology management, language, business, Health policy, media_common
Abstract

The people of Estonia, who until their independence had been systematically deprived of all forms of information, have shown a ready acceptance of the use of information technology in all areas of life. This environment and an excellent IT infrastructure have since the beginning of the new century provided favourable conditions for developing various individual projects in telemedicine. At the core of current telemedical applications in Estonia is the BITNET Project (in neurology, general medicine), built up with Swedish cooperation, and three German-Estonian projects (in telecardiology and telepathology). These projects are accompanied by studies of their cost-effectiveness. They constitute the basis for the plan that routine telemedical services be taken over by the Estonian health insurance. Differing from the situation in the Scandinavian countries, which have had an effective national telemedical service for over ten years, the special feature of telematrics in Estonia is its international networking with foreign centres of excellence. This has its origin in the aim of Estonian health policy to ensure medical services within its own country in all branches of medicine.

Published
2004

6. Subgruppenanalyse aus der nicht-interventionellen Beobachtungsstudie REASON: PFS und OS gemäß Alter, Raucherstatus, Geschlecht und histologischem Subtyp unter Verwendung von Gefitinib bzw. chemotherapeutischer Behandlung bei NSCLC-Patienten

Author

Schuette, W., additional, Eberhardt, W., additional, Waller, C., additional, Schirmacher, P., additional, Dietel, M., additional, Zirrgiebel, U., additional, Radke, S., additional, and Thomas, M., additional

Published
2016
Full Text
View/download PDF

7. HER2-Testung beim Magenkarzinom – Ergebnisse eines deutschen Expertentreffens

Author

Lordick, F., additional, Al-Batran, S., additional, Hofheinz, R., additional, Lorenzen, S., additional, Thuss-Patience, P., additional, Baretton, G., additional, Dietel, M., additional, Gaiser, T., additional, Kirchner, T., additional, Kreipe, H., additional, Quaas, A., additional, Röcken, C., additional, Rüschoff, J., additional, and Tannapfel, A., additional

Published
2016
Full Text
View/download PDF

16. Histondeacetylasen im Mammakarzinom

Author

Jana, L, primary, Kasajima, A, additional, Müller, B, additional, Winzer, KJ, additional, Lehmann, A, additional, Dietel, M, additional, Weichert, W, additional, and Denkert, C, additional

Published
2011
Full Text
View/download PDF

32. Lokalisationsdiagnostik vergrößerter Nebenschilddrüsen: die201Tl-99mTc-Subtraktionsszintigraphie im Vergleich zur 5-MHz-Sonographie

Author

R. Montz, H. P. Kruse, Schumpelick, Müller Hw, Dietel M, and C. Schneider

Subjects
Enlarged parathyroid glands, Primary hyperplasia, medicine.diagnostic_test, business.industry, Subtraction, Nodular thyroid, medicine.disease, Scintigraphy, Medicine, Radiology, Nuclear Medicine and imaging, business, Nuclear medicine, Structural imaging, Primary hyperparathyroidism, Parathyroid adenoma
Abstract

Fifty patients clinically suspected of having primary hyperparathyroidism were examined by scintigraphy (201Tl-99mTc subtraction) and sonography (5 MHz). In 28 cases, the results of subtraction scintigraphy, and in 26 cases, the results of sonography were checked by operation. In 25 patients there was a solitary parathyroid adenoma and in two, primary hyperplasia. In one patient all four parathyroid glands were normal. Subtraction scintigraphy had a sensitivity of 90% and a specificity of 98%, while sonography had a sensitivity of 82% and a specificity of 95%. The combination of 201Tl-99mTc subtraction scintigraphy as a functional investigation and sonography as a structural imaging method produced a sensitivity of 96% and is therefore superior to all other methods of localisation for normally situated glands. Diagnostic certainty is reduced by the presence of a nodular thyroid.

Published
1985

Catalog

Books, media, physical & digital resources
See catalog results