1. Massive Pulmonary Embolism Thrombolysis: Early Clinical Markers of Treatment Efficacy
- Author
-
Mark L. Lessne, Elie Portnoy, Kelvin Hong, Mariana de Carvalho Barbosa, Vibhor Wadhwa, Clifford R. Weiss, Anobel Tamrazi, and B. Holly
- Subjects
Inotrope ,medicine.medical_specialty ,Treatment response ,medicine.diagnostic_test ,business.industry ,medicine.medical_treatment ,Hemodynamics ,Interventional radiology ,Thrombolysis ,medicine.disease ,Treatment efficacy ,Pulmonary embolism ,Blood pressure ,Internal medicine ,Cardiology ,medicine ,Radiology, Nuclear Medicine and imaging ,business - Abstract
The authors seek to evaluate hemodynamic parameters as potential clinical markers of real-time clinical improvement among patients with massive pulmonary embolism (PE) in correlation with post-thrombolytic pulmonary arterial pressure improvement and overall clinical outcome. Thirteen patients with submassive or massive PE were admitted to the interventional radiology service and treated with catheter-directed thrombolysis. Among the four patients who qualified as massive PE, systolic blood pressure (BP) and vasopressor dependence suggested meaningful trends toward clinical improvement, after only 26.4% of treatment course/dose. Hemodynamic parameters such as systolic BP and inotropic vasopressor dependence may be considered in future treatment protocols as early indicators of treatment response.
- Published
- 2018
- Full Text
- View/download PDF