1. MicroRNAs as Regulators and Biomarkers of Platelet Function and Activity in Coronary Artery Disease
- Author
-
Anne Yaël Nossent, Paul M Haller, Kurt Huber, Johann Wojta, Kris G. Vargas, Bernhard Jäger, and Stefan Stojkovic
- Subjects
0301 basic medicine ,Acute coronary syndrome ,Treatment response ,business.industry ,Hematology ,030204 cardiovascular system & hematology ,medicine.disease ,Bioinformatics ,Pathophysiology ,Coronary artery disease ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,microRNA ,Medicine ,In patient ,Platelet ,business ,Function (biology) - Abstract
Microribonucleic acids (miRs) are small, noncoding ribonucleic acids (RNAs), which play an important role in the regulation of platelet function and activity. Several studies proposed a mechanistic role of platelet-related miRs in the pathophysiology of coronary artery disease (CAD) and atherothrombosis. Circulating, platelet-related miRs have been proposed as diagnostic, prognostic, as well as treatment response biomarkers in CAD and acute coronary syndrome (ACS). In this review, we summarize recent studies on the role of platelet-related miRs in the regulation of platelet function and activity. Furthermore, we review the studies investigating the role of platelet-related miRs as biomarkers in patients with CAD and ACS.
- Published
- 2019
- Full Text
- View/download PDF