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In 111 patient suffering from calcium oxalate lithiasis more than 168 citrate and calcium analyses have been performed in 24 hour urine. In 69 patients with a single stone episode no significant difference of citrate concentration was found in comparison with 63 healthy volunteers. However, in 42 recurrent stone formers was the citrate concentration significantly diminished (p less than 0.005). The calcium/citrate ratio was in recurrent stone formers markedly higher (5.19 +/- 8.6) than in patients with a single stone episode (3.34 +/- 4.9). However, because great deviation of citrate values the calcium/citrate ratio may not be suitable for evaluation of stone formation risk.

30 patients who developed an irradiation bladder after radiotherapy of carcinoma uteri were treated with submucosal infiltration of orgotein. In this homogeneous series (same cancer, dosage and exposition of radiation, same sex) the success rate of 86% improvement of subjective symptoms or complete healing was excellent, not to be reached by any other mode of treatment. In one patient an anaphylactic shock was seen. Despite of this event--which happens in great published series in only 1 permille--orgotein infiltration should be the therapy of choice in actinic damaged urinary bladders.