1. Synthesis of Cyclopropyl Pinacol Boronic Esters from Dibromo-cyclopropanes
- Author
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Zeina Neouchy, Jan Hullaert, Jonas Verhoeven, Lieven Meerpoel, Jan-Willem Thuring, Guido Verniest, Johan Winne, Faculty of Physical Education and Physical Therapy, Department of Bio-engineering Sciences, and Chemistry
- Subjects
Matteson-Pasto rearrangement ,borylcyclopropanes ,pinacolborane ,Organic Chemistry ,olefins ,dibromocyclopropanes - Abstract
The synthesis of cyclopropyl pinacol boronic esters from dibromocyclopropanes via Matteson–Pasto rearrangement is reported. The method is readily scalable and shows limited levels of stereoinduction, with a selectivity that is in part complementary to that observed in existing stereoselective borylcyclopropanation strategies. The method can be used to rapidly access borylcyclopropanes as interesting building blocks for diversely functionalized cyclopropanes.
- Published
- 2022