1. [Screening for apoptosis inducers].
- Author
-
Naito M
- Subjects
- Caffeine analogs & derivatives, Cell Death drug effects, Etoposide pharmacology, Humans, U937 Cells drug effects, U937 Cells pathology, U937 Cells ultrastructure, Apoptosis drug effects, Caffeine pharmacology, Reactive Oxygen Species metabolism
- Abstract
We carried out a screening for drugs that can induce apoptosis in human monocytic leukemia U937 cells. In the screening, we found that 8-nitrocaffeine induces cell death distinct from typical apoptosis. Morphological and biochemical analysis revealed that reactive oxygen species mediates the 8-nitrocaffeine-induced necrotic cell death.
- Published
- 2004