1. Tümör mikroçevresinde CD8’in yüksek ekspresyonu, yüksek dereceli seröz over kanserinde PD-1 ekspresyonu ve hasta sağkalımı ile ilişkilidir
- Author
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Fatma Ölmez, Süleyman Cemil Oğlak, Ömer Fatih Ölmez, Özgür Akbayır, Ercan Yılmaz, Sedat Akgöl, Merve Konal, Niyazi Alper Seyhan, and Alp Koray Kinter
- Subjects
Programmed Death-1 Receptor ,Yüksek Dereceli Seröz Over Kanseri ,Tumor-Infiltrating Lymphocytes ,High-Grade Serous Ovarian Cancer ,Obstetrics and Gynecology ,Tümör Infiltre Edici Lenfositler ,Programlanmış Ölüm-1 Reseptörü - Abstract
Objective: The current study assesss programmed death-1 (PD-1) receptor expression and CD3, CD4, and CD8 tumor-infiltrating lymphocytes (TILs) in high-grade serous ovarian cancer (HGSOC) and to associate our results with neoadjuvant chemotherapy history and disease prognosis. Materials and Methods: We included cases diagnosed with primary HGSOC with biopsy or surgical resection materials in this study. The immunoreactivity of CD3, CD4, CD8, and PD1 was assessed immunohistochemically in tumor tissue. We analyzed TILs in two predetermined groups of high and low TIL. The relationships between clinical characteristics, PD-1, and TIL were assessed. by the χ(2) test or Fisher’s Exact test. We used Kaplan-Meier survival analysis and Cox proportional hazards regression model to the connection between survival and the amounts of TIL, and PD1. Results: Univariate analysis demonstrated that optimal debulking (p
- Published
- 2022
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