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Atypical chronic lymphocytic leukemia (CLL) is most frequently confused with mantle cell lymphoma (MCL). Several markers may contribute to the diagnosis of CLL. However, there is no consensus on which markers are needed to be used in flow cytometry for the diagnosis of CLL. The aim of the present study was to investigate the role of CD43 and CD200 markers in the differential diagnosis between CLL and MCL.To address this issue, 339 consecutive patients with CLL and MCL were included in the flow cytometry lymphoproliferative disease panel for evaluation of CD43 and CD200 expressions, but not in the Matutes scoring system.CD200 was expressed in 97.3% of atypical CLL cases, whereas it was dimly expressed in only 6.1% of MCL cases. CD43 expression was 95.7% in atypical CLL cases. In the MCL cases, its expression rate was 39.4%.CD43 and CD200 were found to be more valuable markers than CD22, CD79b, and FMC7. CD43 and CD200 could also be considered as definitive markers in atypical CLL patients, for whom the Matutes scoring system remains ineffective.Amaç: İmmünfenotip olarak atipik kronik lenfositik lösemi (KLL) ile mantle cell lenfoma (MCL) sıklıkla karışabilmektedir. KLL tanısı için birçok marker kullanılmaktadır, ancak akım sitometride KLL tanısı için tam bir konsensüs oluşmamıştır. Bu çalışmada KLL ve MCL ayırıcı tanısında CD43 ve CD200 ifadeleri araştırılmıştır. Gereç ve Yöntemler: Matutes skorlama sisteminde olmayan CD43 ve CD200’ü akım sitometri lenfoproliferatif hastalık paneline dahil ederek 339 KLL ve MCL olgusunda incelenmiştir. Bulgular: Atipik KLL olgularının %97,3’ünde CD200 pozitifken MCL olgularının ise sadece %6,1’inde düşük oranda ifade ediliyordu. CD43’te atipik KLL olgularının %95,7’sinde ifade edilirken MCL olgularının %39,4’ünde donuk ifade ediliyordu. Sonuç: CD43 ve CD200; CD22, CD79b ve FMC7’ye göre daha anlamlı bulundu. CD43 ve CD200 Matutes skorlama sistemi skorunun yetersiz kaldığı KLL olgularının tanısında tamamlayıcı marker olarak kullanılabilir.

Objective The aim of the present study was to evaluate the efficacy and safety of eltrombopag, an oral thrombopoietin receptor agonist, in patients with chronic immune thrombocytopenia (ITP). Materials and Methods A total of 285 chronic ITP patients (187 women, 65.6%; 98 men, 34.4%) followed in 55 centers were enrolled in this retrospective cohort. Response to treatment was assessed according to platelet count (/mm3) and defined as complete (platelet count of >100,000/mm3), partial (30,000-100,000/mm3 or doubling of platelet count after treatment), or unresponsive (

Objective The purpose of this study is to investigate the relationship between the CD56 and CD117 expressions and the clinical and laboratory findings in multiple myeloma (MM) patients. Materials and methods Analyses of multiparametric flow cytometry data obtained from the diagnostic bone marrow aspirations of a total of 34 newly diagnosed MM patients were assessed retrospectively. CD56 and CD117 expressions of the patients were compared with their stages and clinical parameters. The staging was performed according to the International Staging System (ISS). Results Of the patients, 58.8% had ISS stage 1-2 MM while 41.2% had stage 3 MM. The number of CD56-positive patients was 29, whereas the number of CD117-positive patients was 13. There was no statistical difference between the CD56 and CD117 expressions and extramedullary involvement and lytic bone lesions. The median beta-2 microglobulin level was higher in the CD117-negative group (p=0.047). CD56 and CD117 expression levels were found to be lower in advanced-stage patients than in early-stage ones (p=0.026 and p=0.017). The lactate dehydrogenase (LDH) levels were high in advanced-stage patients, and an inverse relationship was found between LDH level and CD117 expression. Conclusion Our findings that the CD56 and CD117 expression levels are lower in advanced stages than earlier stages and that LDH level and CD117 expression have an inverse relationship in patients with newly diagnosed MM suggest that CD56 and CD117 expressions may be prognostic markers for MM.