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Objective: Surfactant administration is usually performed by endotracheal intubation under mechanical ventilation. Less invasive surfactant administration (LISA) technique has became widespread in recent years, in order to prevent the risk of barotrauma and volutrauma caused by mechanical ventilation and intubation. The aim of this prospective study is to evaluate the effectiveness of surfactant administration via a thin catheter during spontaneous breathing on NIPPV and to compare with INSURE method. Method: Seventy-eight preterm infants who were born at university hospital with less than 34 weeks of gestational age and who received surfactant therapy were enrolled. The intratracheal administration of poractant alfa (CUROSURF®) was performed using umbilical catheters in LISA group (n= 42). INSURE group had 36 infants who were intubated, received surfactant then extubated and placed on NIPPV. Results: There were no statistically significant differences between two groups in terms of intubation in the first 72 hours and re-administration of surfactant, the duration of NIPPV and the occurence of pneumothorax, pulmonary hemorrhage, patent ductus arteriosus, intraventricular hemorrhage, early onset neonatal sepsis, necrotising enterocolitis, bronchopulmonary dsyplasia and mortality (p>0.05). The pCO2 values decreased faster in LISA group when compared to INSURE group and this difference was statistically significant (p

Amaç: Yenidoğanlarda göbek veni kateterizasyonu ile ilişkili ritm bozuklukları olgu sunumları ile sınırlıdır Bu çalışma erken doğmuş bebeklerde göbek ven kateterizasyonunun aritmi ve kalp hızı değişkenliği üzerindeki etkisini araştırmak amacıyla yapılmıştır. Gereç ve Yöntem: Çalışma erken doğmuş bebeklerden oluşan iki grupta yapılmıştır Grup I: Göbek ven kateteri takılı olan 26 bebek; grup II: göbek ven kateteri takılı olmayan 26 bebekten oluşmaktadır Bütün bebeklerin cinsiyet doğum haftası doğum kilosu ve klinik değerlendirme puanları SNAP II ve SNAPPE II kaydedildi Bebeklerin hepsine 24 saatlik Holter elektrokardiyografi takıldı Kalp hızı değişkenliği zaman alanlı ve frekans alanlı değişkenler kullanılarak çalışıldı.Bulgular: Çalışmaya alınan bebeklerin ortalama doğum haftası grup 1 rsquo;de 30 63 plusmn;2 67 grup 2 rsquo;de ise 31 60 plusmn;2 45 idi Gruplar arasında doğum haftası doğum ağırlığı SNAP II ve SNAPPE II puanları arasında istatistiksel olarak anlamlı fark saptanmadı Aritmi açısından karşılaştırıldığında iki grup arasında istatistiksel olarak fark bulunmadı Atriyal erken vuru grup 1 rsquo;de 11 hastada 42 3 grup 2 rsquo;de 7 hastada 26 9 saptandı Ventriküler erken vuru grup 1 rsquo;de 3 hastada 11 5 grup 2 rsquo;de bir hastada saptandı Sinüs taşikardisi ise sadece grup 1 rsquo;de yer alan üç hastada bulundu Kalp hızı değişkenliği iki grup arasında istatistiksel olarak farklı bulunmadı.Çıkarımlar: Çalışmamızda göbek ven kateterinin erken doğmuş yenidoğanlar da aritmi veya kalp hızı değişkenliği üzerinde anlamlı bir etkisinin olmadığı gösterilmiştir., Aim: Cardiac rhythm abnormalities associated with umbilical venous catheters in newborns are limited to anecdotal case reports The present study intended to evaluate association between umbilical venous catheter arrhythmic potential and changes in heart rate variability Material and Method: The study consisted of two groups; 26 preterm newborns with a umbilical venous catheter group 1 and 26 control group without group 2 The following parameters were recorded prospectively: gender gestation at birth birth weight and clinical assessment scores SNAP II and SNAPPE II Holter recordings were fitted in all newborns The heart rate variability study was performed by utilizing time domain and frequency domain analyses Results: The study population consisted of group 1 30 63 plusmn;2 67 weeks of gestation and group 2 31 60 plusmn;2 45 weeks of gestation There was no statistical difference between the two groups for gestational age birth weight SNAP II and SNAPPE II scores When compared for arrhythmia there was no statistical difference in any parameters between the two study groups Premature atrial contraction was noted in 11 babies 42 3 in group 1 and in 7 babies 26 9 in group 2 Premature ventricular contraction was noted in 3 babies 11 5 in group 1 and in one baby in group 2 Sinus tachycardia detected in 3 patients in only the group 1 None of the heart rate variability parameters were found to be statistically different between the two groups Conclusions: Our study reassuringly demonstrated that umbilical venous catheter does not have any significant effect on arrhythmia or heart rate variability in preterm newborns Turk Arch Ped 2013; 48: 131 7