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Introduction: Healthcare-associated infections (HCAIs) have increased during the COVID-19 pandemic due to inadequate adherence to infection control measures. Central-line-associated bloodstream infections (CLBSI) are one of the infections with an increased incidence. In this study, CLBSI-SIRs in 3 periods were compared, and the impact of the COVID-19 pandemic on CLBSI observed in intensive care units (ICUs) was evaluated. The hand hygiene compliance rates were also examined for the same period. Materials and Methods: Comparisons of 2019, 2020, and 2021 were made by calculating the 3-year SIR, standardized utilization ratio (SUR), and SIR change rates between years in 12 adult ICUs. Calculations were made using the SIR and SUR calculation tool prepared by the General Directorate of Public Health of Turkey. The formula [(SIR/SUR of year Y – SIR/SUR of year X) / SIR/SUR x 100 of year X] was used when calculating the SIR/SUR change rates between periods. Results: In 2019 and 2020, SIR was detected as >1 only in the burn ICU. Anesthesia and Reanimation-1,2 and Internal Medicine-3 were the ICUs with the highest SIR increase rate in 2020. In 2021, it was determined as SIR1 in all periods. When the mean SIR of ICUs between 2019, 2020, and 2021 was compared, the rate was significantly higher in 2020 (p < 0.05). There was a significant increase in hand hygiene compliance in 2021 compared to previous years (p < 0.05). Conclusion: With the COVID-19 pandemic, an increase in CLBSI-SIR was observed in 2020. In 2021, a decrease in CLBSI-SIR and an increase in hand hygiene compliance were achieved by gaining experience in the follow-up and treatment of patients diagnosed with COVID-19, implementing infection control programs, and conducting on-site training and inspections.

Introduction: The population is aging, and older adults comprise most patients in the intensive care units. Colistin (COL) has been re-introduced to treat increasingly common resistant Gram-negative bacterial infections. Our study aims to investigate the factors affecting COL nephrotoxicity in a general population and geriatric age group. Materials and Methods: This retrospective study included 170 patients, a total of 116 (68.2%) of whom were in the geriatric group (age ≥65). Acute renal failure was evaluated using the RIFLE score. Factors associated with COL nephrotoxicity were described firstly in a general population and then in the geriatric group patients. Results: Advanced age [Odds ratio (OR): 1.043; 95% confidence interval (CI): 1.018-1.068; p=0.001] and initial serum creatinine level (OR: 23.122; 95% CI: 3.123-171.217; p=0.002) were found to be the independent risk factors associated with nephrotoxicity. In the evaluation of the geriatric population based on nephrotoxicity, the initial serum urea and creatinine levels, and overall mortality rates were found to be statistically significantly higher in the group with nephrotoxicity (p