1. Evaluating the expression of tumorigenic long noncoding RNAs in circulating exosomes isolated from non-small-cell lung cancer patients
- Author
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Zhenshan Shi, Kaicheng Huang, Zheng Li, Yanli Niu, and Lihao Jiang
- Subjects
Lung Neoplasms ,Carcinogenesis ,Carcinoma, Non-Small-Cell Lung ,Biochemistry (medical) ,Clinical Biochemistry ,Drug Discovery ,Humans ,RNA, Long Noncoding ,Exosomes ,Prognosis - Abstract
Aim: To evaluate the correlation of long noncoding RNAs (lncRNAs) expression in circulating exosomes and the cancerous and noncancerous tissues in patients with non-small-cell lung carcinoma. Methods: The relative expression of the four lncRNAs including LUADT1, MALAT1, NEAT1 and MIAT between tumor tissue, adjacent noncancerous tissues and circulating exosomes were evaluated by quantitative reverse transcription PCR. Results & conclusion: The relative expression of the lncRNAs, including LUADT1, MALAT1 and NEAT1, was upregulated and MIAT was downregulated in tumor tissue compared with noncancerous tissue samples. The expression of lncRNAs in circulating exosomes was not significantly different from cancerous tissue. Our results indicate that the studied exosomal lncRNAs have a good potential to be further evaluated as prognostic/diagnostic biomarkers in patients with non-small-cell lung cancer.
- Published
- 2022
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