1. Liver and brain imaging through dimercaptosuccinic acid-coated iron oxide nanoparticles.
- Author
-
Mejías R, Pérez-Yagüe S, Roca AG, Pérez N, Villanueva A, Cañete M, Mañes S, Ruiz-Cabello J, Benito M, Labarta A, Batlle X, Veintemillas-Verdaguer S, Morales MP, Barber DF, and Serna CJ
- Subjects
- Animals, Cell Survival, HeLa Cells, Humans, Nanoparticles ultrastructure, Rats, Brain anatomy & histology, Ferric Compounds chemistry, Liver anatomy & histology, Magnetic Resonance Imaging methods, Nanoparticles chemistry, Succimer chemistry
- Abstract
Background & Aim: Uptake, cytotoxicity and interaction of improved superparamagnetic iron oxide nanoparticles were studied in cells, tissues and organs after single and multiple exposures., Material & Method: We prepared dimercaptosuccinic acid-coated iron oxide nanoparticles by thermal decomposition in organic medium, resulting in aqueous suspensions with a small hydrodynamic size (< 100 nm), high saturation magnetization and susceptibility, high nuclear magnetic resonance contrast and low cytotoxicity., Results: In vitro and in vivo behavior showed that these nanoparticles are efficient carriers for drug delivery to the liver and brain that can be combined with MRI detection.
- Published
- 2010
- Full Text
- View/download PDF