1. Imaging characteristics of zinc sulfide shell, cadmium telluride core quantum dots
- Author
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Marcel P. Bruchez, Jean A. Tkach, Hamid Daneshvar, Steven A. Toms, William J. Davros, Jennifer Nelms, Michael A. Vogelbaum, Todd E. Peterson, Osman Muhammad, and Heather M. Jackson
- Subjects
Fluorophore ,Materials science ,Quantitative Biology::Tissues and Organs ,Physics::Medical Physics ,Biomedical Engineering ,Contrast Media ,Medicine (miscellaneous) ,Nanoparticle ,Bioengineering ,Nanotechnology ,Sulfides ,Development ,chemistry.chemical_compound ,Telluride ,Materials Testing ,Quantum Dots ,Cadmium Compounds ,Animals ,General Materials Science ,Brain ,Image Enhancement ,equipment and supplies ,Condensed Matter::Mesoscopic Systems and Quantum Hall Effect ,Photobleaching ,Rats, Inbred F344 ,Cadmium telluride photovoltaics ,Rats ,Microscopy, Fluorescence ,Nanocrystal ,chemistry ,Zinc Compounds ,Quantum dot ,Tellurium ,Molecular imaging - Abstract
Aims: Quantum dots are optical nanocrystals whose in vitro and in vivo use in molecular imaging is expanding rapidly. In comparison with organic fluorophores, quantum dots exhibit desirable properties, such as multiwavelength fluorescence emission, excellent brightness and resistance to photobleaching. Their electron-dense, metallic cores suggest utility in other clinical imaging modalities. Methods: Core-shell zinc sulfide-cadmium telluride quantum dots were studied by magnetic resonance and computed tomography phantoms. Quantum dots were also injected into rat brain, as well as intravenously, using convection-enhanced delivery, prior to animal imaging. Results: Computed tomography studies suggest that current formulations of quantum dots might be imaged in vivo in animals. Conclusions: Used in conjunction with optical imaging techniques, quantum dots have the potential to function as multimodal imaging platforms in vivo. The ability to detect an optical nanoparticle preoperatively with clinical imaging modality offers a distinct advantage to clinicians engaged in image-guided surgical applications.
- Published
- 2008
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