1. Female sex impact on culprit plaque at optical coherence tomography analysis in the setting of acute coronary syndrome in OCT-FORMIDABLE registry.
- Author
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Giordana, Francesca, Errigo, Daniele, D'Ascenzo, Fabrizio, Montefusco, Antonio, Garbo, Roberto, Omedè, Pierluigi, D'Amico, Maurizio, Moretti, Claudio, Tamburino, Corrado, and Ferrari, Gaetano M De
- Subjects
RESEARCH ,RESEARCH methodology ,ACQUISITION of data ,ACUTE coronary syndrome ,RETROSPECTIVE studies ,MEDICAL cooperation ,EVALUATION research ,ATHEROSCLEROSIS ,COMPARATIVE studies ,OPTICAL coherence tomography ,ELECTROCARDIOGRAPHY ,CORONARY arteries ,LONGITUDINAL method - Abstract
Aim: To evaluate sex difference in culprit plaque features at optical coherence tomography (OCT) and major adverse cardiovascular events at follow-up. Patients and methods: We analyse data from the OCT-FORMIDABLE (OCT-Features Of moRphology, coMposItion anD instABility of culprit and pLaquE in acute coronary syndrome [ACS] patients) registry. A total of 285 patients (20%, 58 females) were included. Results: Females with ST segment elevation myocardial infarction showed a longer ruptured area of the plaque (8.6 ± 7.6 vs 4.6 ± 5.4; p = 0.003) and a major necrotic core macrophage infiltration (43 vs 17%; p = 0.017). Females with non-ST segment elevation-ACS had less lipidic plaques (62 vs 80%; p = 0.04). No between-group sex differences in major adverse cardiovascular events emerged at follow-up (5 vs 9%; p = 0.88 in ST segment elevation myocardial infarction group and 19 vs 15%; p = 0.6 in non-ST segment elevation-ACS group). At multivariate analysis, female sex was not a major risk of plaque rupture (hazard ratio [HR]: 1.59, CI: 0.44-5.67; p = 0.48). Conclusion: Female sex seems to have no significant impact. ClincalTrial. gov registration number: NCT02486861. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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