1. Association of the g.19074G>A genetic variant in the osteoprotegerin gene with bone mineral density in Chinese postmenopausal women.
- Author
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Zhang YD, Zhang Z, Zhou NF, Jia WT, Cheng XG, and Wei XJ
- Subjects
- Absorptiometry, Photon, Aged, Alleles, Asian People genetics, Binding Sites genetics, China, DNA Mutational Analysis methods, Deoxyribonucleases, Type II Site-Specific metabolism, Female, Gene Frequency, Genetic Predisposition to Disease ethnology, Genotype, Humans, Linkage Disequilibrium, Middle Aged, Osteoporosis, Postmenopausal ethnology, Polymerase Chain Reaction, Risk Factors, Bone Density genetics, Genetic Predisposition to Disease genetics, Osteoporosis, Postmenopausal genetics, Osteoprotegerin genetics, Polymorphism, Single Nucleotide
- Abstract
Primary osteoporosis is a common health problem in postmenopausal women. This study aimed to detect the association of the g.19074G>A genetic variant in the osteoprotegerin gene (OPG) with bone mineral density (BMD) and primary osteoporosis. The created restriction site-polymerase chain reaction method was used to investigate the g.19074G>A genetic variant. The BMD of the femoral neck hip, lumbar spine (L2-4), and total hip were assessed by dual-energy X-ray absorptiometry (DEXA) in 856 unrelated Chinese postmenopausal women. We found significant differences in the BMDs of the femoral neck hip, lumbar spine (L2-4), and total hip among different genotypes; individuals with the GG genotype had significantly higher BMDs than those with the GA and AA genotypes (P < 0.05). Our results indicated that the A allele was an increased risk factor for primary osteoporosis and the g.19074G>A genetic variant of the OPG gene was associated with BMD and primary osteoporosis in Chinese postmenopausal women.
- Published
- 2014
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