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Objective To observe the effect of nalbuphine on postoperative analgesia after laparoscopic radical cervical cancer surgery. Methods Sixty patients with ASA Ⅰ - Ⅱ underwent laparoscopic radical cervical cancer surgery in Obstetrics & Gynecology Hospital, Fudan University from Sep 2017 to Feb 2018 were randomly divided into group nalbuphine (N, n=29）and group sufentanil (S, n= 27) by random number table. Nalbuphine and sufentanil were used for pain management during the perioperative period respectively. We measured visual analogue score (VAS) in motion and static state at postoperative 2, 6, 12, 24 and 48 h, the number of patient-controlled analgesia (PCA) the number of nausea, vomiting and adverse reactions. Results VAS scores in both static and motion state at postoperative 2, 6, 12 h as well as VAS scores in motion state at postoperative 24 h in group N were significantly lower than those in group S (P<0.05). The number of PCA, nausea, vomiting and other adverse reactions in the two groups were not significantly different. Conclusion Compared with sufentanil, nalbuphine was associated with lower postoperative pain score after laparoscopic radical surgery for cervical cancer without increasing adverse reactions. [ABSTRACT FROM AUTHOR]