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A suboptimal housing environment such as small cage size can adversely influence many aspects of the biology of laboratory animals including their response in behavioral tests. However, the effect of cage size on the mental and physical conditions of Kunming mice, which have been widely used to develop models of depression, anxiety, and many other diseases in China, are still far from clear. The purpose of this study was to investigate the effects of cage size on reproductive ability, exploratory behavior, anxiety, and working memory of Kunming mice. Two cage sizes were used, including a standard cage (20 × 30 × 25 cm 3 ) and a restricted cage (10 × 20 × 25 cm 3 ). The results revealed that compared with mice in the standard cages, mice in the restricted cages showed: (I) a decreased delivery rate of dams ( P < 0.05) and a lower survival rate of offspring ( P < 0.05), specifically in females ( P < 0.05); (II) a decreased exploratory behavior ( P < 0.01) and an increased anxiety level ( P < 0.01); and (III) higher working memory in the T -maze test ( P < 0.05). These results indicated that a restricted cage size has detrimental effects on the reproductive ability and anxiety level, but its effect on cognitive ability is complex and warrants further study. In short, these results provide empirical evidence for better practices in caring for Kunming mice, with some cautions about the effects of cage size on behavioral tests., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2021 An, Zhang, Zhou and Hu.)

Considerable research has shown that children with dyslexia have deficits in visual spatial attention orientation. Additionally, self-referential processing makes self-related information play a unique role in the individual visual spatial attention orientation. However, it is unclear whether such self-referential processing impacts the visual spatial attention orientation of children with dyslexia. Therefore, we manipulated the reference task systematically in the cue-target paradigm and investigated the modulation effect of self-referential processing on visual spatial attention of children with dyslexia. In the self-referential processing condition, we observed that children with dyslexia demonstrated stable cue effects in the visual spatial attention orientation tasks when the Stimulus Onset Asynchronies (SOAs) were set to 100 ms, while other-referential processing weakened the cue effects of the visual spatial attention orientation of children with dyslexia. With cue effect as the index, we also observed that the self-referential processing had a significant larger regulatory effect at the early stage of visual spatial attention orientation, as compared with other-referential processing. These differences have a high-ranked consistency between children with dyslexia and typically developing reader. The results suggested that self-referential processing can regulate the visual spatial attention deficits of children with dyslexia., (Copyright © 2019 Zhou, Duan, Wen, Wu, Li, Ma and Tan.)

The self-face is the unique representation of oneself, and it has a processing advantage over familiar faces and the faces of strangers. Generally, recognition of the self-face is significantly faster or more accurate in a variety of tasks compared with recognizing others' faces. While previous studies that used the present self-face as stimuli have found a processing advantage, what happens when the self-face turns old? To investigate whether an old self-face can still produce the processing advantage, we conducted two experiments. Experiment 1 used a standard visual search paradigm, and Experiment 2 used the implicit association test. In both experiments, the old self-face was compared with the present self-face or an old friend-face. We found that when the self-face turns old, the processing advantage disappears. This research demonstrates a new way to investigate the future self.

Previous studies have documented that people tend to respond faster and memorize better to the in-group traits. It may be particularly manifest for ethnic minorities, due to their salient ethnic identity. However, few studies have explored how the valence of traits modulates the in-group preference effect. The present study examined the impacts of ethnic identity salience and the valence of traits on the group-preference effect among 33 Han Chinese in a Tibetan-dominant area and 32 Tibetan participants in a Han-dominant area. Two weeks before the experiment, we measured the ethnic identity salience of participants in both groups. In the formal experiment, we used the group-reference effect (GRE) paradigm with three encoding tasks. The results showed that, regardless of whether ethnic identity was salient, both groups responded faster to positive traits than to negative traits when evaluating their own group, whereas there were no significant difference between the processing of positive traits and negative traits in the out-group evaluation and font judgment tasks. This suggested a pervasive processing advantage of the in-group positive characteristics. The results imply that self-enhancement motivation had a moderation effect on the GRE, as well as the ethnic identity salience may not be necessary for a GRE.

Existing neuroimaging studies have shown that religion, as a subjective culture, can influence self-referential processing. However, the time course of this impact remains unclear. The present study examined how Christians process their own names, the name of their religious leader (i.e., Jesus), and a famous person's name (i.e., Yao Ming). Behavioral and EEG data were recorded while the participants performed a name-color judgment task for these three names. The behavioral data showed no significant differences in reaction time or accuracy among the names. However, the ERP data showed that the P200 and P300 amplitudes elicited by the self-name and religious leader name were larger than those elicited by the famous name. Furthermore, the self-name also elicited a larger P300 amplitude than the religious leader name did. These results suggested that both the self-name and the religious leader name were processed preferentially due to their important social value for the self as compared to a generally famous name. Importantly, the dissociation between the self-name and the religious leader name was observed at a high-order cognitive stage, which might be attributed to their different roles in one's self-concept.

A growing number of studies have demonstrated preferential processing of self-related information. However, previous research has been limited in examining the distinction between processes related to the self and those related to the non-self, it remains unclear how self-related information with differing levels of importance is processed within the self. The present study examined how the importance of self-related content affects the neural activity involved in self-referential processing. The behavioral results showed that the participants had faster responses to more important self-related content. The event-related potential (ERP) results showed that early attention resources were diverted to the identification of highly important self-related content compared with minimally important self-related content, as reflected by the enhanced P200. Furthermore, the N200 amplitude for highly important self-related content was smaller than for moderately important self-related content which, in turn, were smaller than minimally important self-related content. Moreover, the P300 amplitudes were modulated by the degree of importance of self-related content, whereby a higher importance of self-related content led to larger P300 amplitudes. Taken together, these findings demonstrate an effect of the degree of importance of the self-related content at both behavioral and neurophysiological levels.