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18 results on '"Zhou, Qihui"'

12. Regulation of T Cell Responses by Nano-Hydroxyapatite to Mediate the Osteogenesis

Author

Guo, Fangze, Yuan, Changqing, Huang, Hailin, Deng, Xuyang, Bian, Zirui, Wang, Danyang, Dou, Keke, Mei, Li, and Zhou, Qihui

Subjects
Histology, Biomedical Engineering, Bioengineering, Biotechnology
Abstract

Nano-hydroxyapatite (nHA) has been widely applied as a tissue-engineering biomaterial and interacted with osteoblasts/stem cells to repair bone defects. In addition, T cells that coexist with osteoblasts/stem cells in the bone modulate the regulation of osteoimmunology by cytokine formation. However, the effects of nHA on T cells and the following regulatory interplay on osteogenic differentiation have been rarely examined. In this work, the physicochemical properties of needle-like nHA are characterized by field emission scanning electron microscopy, zeta potential, Fourier transform-infrared and X-ray diffraction. It is found that as the concentration of nHA increases, the proliferation of T cells gradually increases, and the proportion of apoptotic T cells decreases. The percentage of CD4+ T cells is higher than that of CD8+ T cells under the regulation of needle-like nHA. Furthermore, the supernatant of T cells co-cultured with nHA significantly inhibits the osteogenic differentiation of MC3T3-E1 by downregulating the formation of alkaline phosphatase and calcium nodule compared with the supernatant of nHA. Thus, our findings provide new insight into the nHA-mediated T cell and osteoblast interactions.

Published
2022

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