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Your search keyword '"Zhao, Xiaoshan"' showing total 17 results
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17 results on '"Zhao, Xiaoshan"'

1. Identification of inhibitors from a functional food-based plant Perillae Folium against hyperuricemia via metabolomics profiling, network pharmacology and all-atom molecular dynamics simulations

Author

Wu, Chuanghai, primary, Wong, Ann Rann, additional, Chen, Qinghong, additional, Yang, Shuxuan, additional, Chen, Meilin, additional, Sun, Xiaomin, additional, Zhou, Lin, additional, Liu, Yanyan, additional, Yang, Angela Wei Hong, additional, Bi, Jianlu, additional, Hung, Andrew, additional, Li, Hong, additional, and Zhao, Xiaoshan, additional

Published
2024
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8. Gut Commensal Fungi Protect Against Acetaminophen-Induced Hepatotoxicity by Reducing Cyp2a5 Expression in Mice

Author

He, Zhuoen, primary, Zeng, Yunong, additional, Li, Shuyu, additional, Lin, Lizhen, additional, Zhou, Ruisi, additional, Wang, Fangzhao, additional, Yang, Wenjiao, additional, Wu, Yuhao, additional, Yang, Junhao, additional, Chen, Ali, additional, Wang, Zhang, additional, Yang, Hong, additional, Zhao, Xiaoshan, additional, Xiao, Wei, additional, Li, Lei, additional, and Gong, Shenhai, additional

Published
2022
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9. Autophagy-Related Genes Are Involved in the Progression and Prognosis of Asthma and Regulate the Immune Microenvironment

Author

Yang, Fan, Kong, Jingwei, Zong, Yuhan, Li, Zhuqing, Lyu, Mingsheng, Li, Wanyang, Li, Wenle, Zhu, Haoyue, Chen, Shunqi, Zhao, Xiaoshan, and Wang, Ji

Subjects
Immunology, Autophagy, Animals, Humans, Immunology and Allergy, Prognosis, Asthma, Epithelium, Serpins, Autophagy-Related Protein 5
Abstract

BackgroundAutophagy has been proven to play an important role in the pathogenesis of asthma and the regulation of the airway epithelial immune microenvironment. However, a systematic analysis of the clinical importance of autophagy-related genes (ARGs) regulating the immune microenvironment in patients with asthma remains lacking.MethodsClustering based on the k-means unsupervised clustering method was performed to identify autophagy-related subtypes in asthma. ARG-related diagnostic markers in low-autophagy subtypes were screened, the infiltration of immune cells in the airway epithelium was evaluated by the CIBERSORT, and the correlation between diagnostic markers and infiltrating immune cells was analyzed. On the basis of the expression of ARGs and combined with asthma control, a risk prediction model was established and verified by experiments.ResultsA total of 66 differentially expressed ARGs and 2 subtypes were identified between mild to moderate and severe asthma. Significant differences were observed in asthma control and FEV1 reversibility between the two subtypes, and the low-autophagy subtype was closely associated with severe asthma, energy metabolism, and hormone metabolism. The autophagy gene SERPINB10 was identified as a diagnostic marker and was related to the infiltration of immune cells, such as activated mast cells and neutrophils. Combined with asthma control, a risk prediction model was constructed, the expression of five risk genes was supported by animal experiments, was established for ARGs related to the prediction model.ConclusionAutophagy plays a crucial role in the diversity and complexity of the asthma immune microenvironment and has clinical value in treatment response and prognosis.

Published
2022

12. JMJD1A/NR4A1 Signaling Regulates the Procession of Renal Tubular Epithelial Interstitial Fibrosis Induced by AGEs in HK-2

Author

Wang, Shaoting, primary, Zuo, Anna, additional, Jiang, Weiqiang, additional, Xie, Jiarun, additional, Lin, Haoyu, additional, Sun, Wei, additional, Zhao, Min, additional, Xia, Jinjin, additional, Shao, Junqiao, additional, Zhao, Xiaoshan, additional, Liang, Donghui, additional, Yang, Aicheng, additional, Sun, Jia, additional, and Wang, Ming, additional

Published
2022
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13. Ginger Extract Decreases Susceptibility to Dextran Sulfate Sodium-Induced Colitis in Mice Following Early Antibiotic Exposure

Author

Zhou, Xinghong, primary, Liu, Xiaoyu, additional, He, Qiuxing, additional, Wang, Ming, additional, Lu, Hanqi, additional, You, Yanting, additional, Chen, Liqian, additional, Cheng, Jingru, additional, Li, Fei, additional, Fu, Xiuqiong, additional, Kwan, Hiu Yee, additional, Zhou, Lin, additional, and Zhao, Xiaoshan, additional

Published
2022
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14. Citrus reticulatae pericarpium Extract Decreases the Susceptibility to HFD-Induced Glycolipid Metabolism Disorder in Mice Exposed to Azithromycin in Early Life

Author

Lu, Hanqi, primary, You, Yanting, additional, Zhou, Xinghong, additional, He, Qiuxing, additional, Wang, Ming, additional, Chen, Liqian, additional, Zhou, Lin, additional, Sun, Xiaomin, additional, Liu, Yanyan, additional, Jiang, Pingping, additional, Dai, Jiaojiao, additional, Fu, Xiuqiong, additional, Kwan, Hiu Yee, additional, Zhao, Xiaoshan, additional, and Lou, Linjie, additional

Published
2021
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