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Ischemic stroke is common in the elderly, and is one of the main causes of long-term disability worldwide. After ischemic stroke, spontaneous recovery and functional reconstruction take place. These processes are possible thanks to neuroplasticity, which involves neurogenesis, synaptogenesis, and angiogenesis. However, the repair of ischemic damage is not complete, and neurological deficits develop eventually. The WHO recommends acupuncture as an alternative and complementary method for the treatment of stroke. Moreover, clinical and experimental evidence has documented the potential of acupuncture to ameliorate ischemic stroke-induced neurological deficits, particularly sequelae such as dyskinesia, spasticity, cognitive impairment, and dysphagia. These effects are related to the ability of acupuncture to promote spontaneous neuroplasticity after ischemic stroke. Specifically, acupuncture can stimulate neurogenesis, activate axonal regeneration and sprouting, and improve the structure and function of synapses. These processes modify the neural network and function of the damaged brain area, producing the improvement of various skills and adaptability. Astrocytes and microglia may be involved in the regulation of neuroplasticity by acupuncture, such as by the production and release of a variety of neurotrophic factors, including brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF). Moreover, the evidence presented indicates that acupuncture promotes neuroplasticity by modulating the functional reconstruction of the whole brain after ischemia. Therefore, the promotion of neuroplasticity is expected to become a new target for acupuncture in the treatment of neurological deficits after ischemic stroke, and research into the mechanisms responsible for these actions will be of significant clinical value.

Geopolitical borderlands are politically sensitive areas and biodiversity hotspots, strictly controlled by the government and military. How to ensure political security, while protecting the biodiversity in borderlands is a problem for ecologists and governments. In this study, the nest site selection of the wild boar Sus scrofa was a case study in the Sino-Russia borderland to understand the survival strategy of wild life under anthropogenic pressure. We investigated (a) how the spatial distribution of anthropogenic pressure and wild boar nests in the borderland and (b) how anthropogenic pressure and the border influence on the wild boars’ nest site selection. The Getis-Ord Gi* analysis was used to analyze the distribution patterns of wild boar nest sites and anthropogenic pressures in the borderland, the Structural Equation Models was used to explore the influence of border, roads, settlements, agricultural land, grassland and anthropogenic pressure on wild boars’ nest site selection. The results indicated that wild boar nest sites are close to the border, roads and agricultural land and away from settlements and grassland. Regardless of the combination of anthropogenic pressure, wild boars make the most advantageous choice and prefer to be closer to the borderland. We speculated that military control played a vital role in borderlands for animal protection under anthropogenic pressure. Wild boars benefit from the prohibition of anthropogenic persecution due to military control. Compared with existing measures, we suggest a different protection/wildlife management strategy, what we need to do may be to prohibit anthropogenic persecution rather than perform other human interventions to protect animals. However, for a species with trouble potential, we need to base our conservation strategies on the recovery of top predators, and play the community control role of top predators to avoid the occurrence of trouble.

The induction of a coma by traumatic brain injury (TBI) is a crucial factor for poor clinical prognoses. We report that acupuncture at the hand 12 Jing-Well points (HTWP) improved consciousness and neurologic function in TBI rats. Gene chip analyses showed that HTWP acupuncture mostly activated genes modulating neuronal projections (P2rx7, P2rx3, Trpv1, Tacr1, and Cacna1d), protein secretion (Exoc1, Exoc3l1, Fgb, and Fgr), and dopamine (DA) receptor D3 (Drd3) in the ventral periaqueductal gray (vPAG), among which the expression rate of P2rx7 was the most obviously increased. Acupuncture also increased the expression and excitability of DA and P2RX7 neurons, and the DA neurons expressed P2RX7, P2RX3, and TRPV1 in the vPAG. Intracerebroventricular administration of P2RX7, P2RX3, or TRPV1 antagonists blocked acupuncture-induced consciousness, and the subsequent injection of a P2RX7 antagonist into the vPAG nucleus also inhibited this effect. Our findings provide evidence that acupuncture alleviates TBI-induced comas via DA neurons expressing P2RX7 in the vPAG, so as to reveal the cellular and molecular mechanisms of the improvement of TBI clinical outcomes by HTWP acupuncture.