1. Curcumin Supplementation Protects Broiler Chickens Against the Renal Oxidative Stress Induced by the Dietary Exposure to Low Levels of Aflatoxin B1
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Sara Damiano, Watanya Jarriyawattanachaikul, Flavia Girolami, Consiglia Longobardi, Carlo Nebbia, Emanuela Andretta, Chiara Lauritano, Sihem Dabbou, Giuseppina Avantaggiato, Achille Schiavone, Paola Badino, Roberto Ciarcia, Damiano, S., Jarriyawattanachaikul, W., Girolami, F., Longobardi, C., Nebbia, C., Andretta, E., Lauritano, C., Dabbou, S., Avantaggiato, G., Schiavone, A., Badino, P., and Ciarcia, R.
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2. Zero hunger ,chicken--broiler ,0303 health sciences ,oxidative stre ,kidney ,Aflatoxin B1 ,General Veterinary ,Veterinary medicine ,030302 biochemistry & molecular biology ,renal damage ,chicken—broiler ,curcumin ,oxidative stress ,turmeric powder ,Aflatoxin B1, turmeric powder, curcumin, oxidative stress, kidney, chicken—broiler, renal damage ,03 medical and health sciences ,SF600-1100 ,Veterinary Science ,Original Research ,030304 developmental biology - Abstract
Aflatoxin B1 (AFB1) causes hepatotoxicity, immunotoxicity, and kidney damage, and it is included in group I of human carcinogens. The European Commission has established maximum limits of AFB1 in feed, ranging from 5 to 20 μg/kg. Chicken is moderately sensitive to AFB1, which results in reduced growth performance and economic losses. Oxidative stress triggered by AFB1 plays a crucial role in kidney damage and the antioxidant activity of Curcumin (CURC) could help in preventing such adverse effect. Twenty-days-old broilers were treated for 10 days with AFB1 (0.02 mg/kg feed), alone or in combination with CURC (400 mg/kg feed), to explore the effects on the renal tissue. Animals exposed to AFB1 alone displayed alterations of the oxidative stress parameters compared with controls: serum antioxidant capacity, and enzymatic activity of kidney superoxide dismutase, catalase and glutathione peroxidase were decreased, while renal malondialdehyde levels and NADPH oxidase complex expression were increased. The administration of CURC attenuates all the oxidative stress parameters modified by AFB1 in the chicken kidney, opening new perspectives in the management of aflatoxicosis.
- Published
- 2022
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