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8 results on '"Pirchio, Rosa"'

1. Metabolic effects of prolactin

Author

Pirchio, Rosa, primary, Graziadio, Chiara, additional, Colao, Annamaria, additional, Pivonello, Rosario, additional, and Auriemma, Renata S., additional

Published
2022
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2. Vitamin D Reverts the Exosome-Mediated Transfer of Cancer Resistance to the mTOR Inhibitor Everolimus in Hepatocellular Carcinoma

Author

Negri, Mariarosaria, primary, Amatrudo, Feliciana, additional, Gentile, Annalisa, additional, Patalano, Roberta, additional, Montò, Tatiana, additional, de Angelis, Cristina, additional, Simeoli, Chiara, additional, Pirchio, Rosa, additional, Auriemma, Renata Simona, additional, Colao, Annamaria, additional, Pivonello, Rosario, additional, and Pivonello, Claudia, additional

Published
2022
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4. Effects of Pituitary Surgery and High-Dose Cabergoline Therapy on Metabolic Profile in Patients With Prolactinoma Resistant to Conventional Cabergoline Treatment

Author

Pirchio, Rosa, primary, Auriemma, Renata S., additional, Solari, Domenico, additional, Arnesi, Mauro, additional, Pivonello, Claudia, additional, Negri, Mariarosaria, additional, de Angelis, Cristina, additional, Cavallo, Luigi M., additional, Cappabianca, Paolo, additional, Colao, Annamaria, additional, and Pivonello, Rosario, additional

Published
2021
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6. The Interplay Between Prolactin and Reproductive System: Focus on Uterine Pathophysiology

Author

Auriemma, Renata S., primary, Del Vecchio, Guendalina, additional, Scairati, Roberta, additional, Pirchio, Rosa, additional, Liccardi, Alessia, additional, Verde, Nunzia, additional, de Angelis, Cristina, additional, Menafra, Davide, additional, Pivonello, Claudia, additional, Conforti, Alessandro, additional, Alviggi, Carlo, additional, Pivonello, Rosario, additional, and Colao, Annamaria, additional

Published
2020
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8. Vitamin D Reverts the Exosome-Mediated Transfer of Cancer Resistance to the mTOR Inhibitor Everolimus in Hepatocellular Carcinoma

Author

Mariarosaria Negri, Feliciana Amatrudo, Annalisa Gentile, Roberta Patalano, Tatiana Montò, Cristina de Angelis, Chiara Simeoli, Rosa Pirchio, Renata Simona Auriemma, Annamaria Colao, Rosario Pivonello, Claudia Pivonello, Negri, Mariarosaria, Amatrudo, Feliciana, Gentile, Annalisa, Patalano, Roberta, Montò, Tatiana, de Angelis, Cristina, Simeoli, Chiara, Pirchio, Rosa, Auriemma, Renata Simona, Colao, Annamaria, Pivonello, Rosario, and Pivonello, Claudia

Subjects
Cancer Research, drug resistance, animal structures, Oncology, embryonic structures, fungi, everolimu, exosomes, HCC, PI3K/Akt/mTOR pathway
Abstract

Several multi-kinase inhibitors were widely tested as potential first-line or second-line therapy in patients with advanced hepatocellular carcinoma (HCC). However, acquired drug resistance limits their clinical efficacy. Exosomes are microvesicles secreted by tumor and stromal cells that participate in many biological processes, including drug resistance. The current study evaluated the capability of exosomes derived from everolimus (EVE)-resistant HCC cells in inducing drug resistance in parental human HCC cells and the effect of 1,25(OH)2Vitamin D (VitD) treatment in restoring EVE sensitivity. The internalization of exosomes from EVE-resistant (EveR) cells into parental cells conferred the transmission of aggressive phenotype by promoting the transition of epithelial-to-mesenchymal phenotype, as demonstrated by immunofluorescence, and the acquisition of EVE resistance, as demonstrated by cell proliferation and colony formation assays. Moreover, the internalization of exosomes from EveR into parental cells induced deregulation of the mTOR pathway mainly by triggering the activation of the serine/threonine protein kinase Akt, involved in the cellular survival pathway, as demonstrated by Western blot analysis. Interestingly, the treatment with VitD prevented exosome-induced EVE resistance in HCC cells, significantly inhibiting cell proliferation but also partially reducing colony and size number when combined with EVE compared with control. In conclusion, the results of the current study demonstrated that exosomes derived from EveR cells could induce EVE resistance in EVE-sensitive HCC cells and that VitD can revert the exosome-induced EVE resistance by resensitizing to EVE treatment.

Published
2022
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