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Your search keyword '"Liu, Xueyuan"' showing total 21 results
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21 results on '"Liu, Xueyuan"'

3. Genomic selection analysis of morphological and adaptation traits in Chinese indigenous dog breeds

Author

Li, Yangfeng, primary, Huang, Min, additional, Wang, Zhenjie, additional, Liu, Xueyuan, additional, He, Shan, additional, Wang, Tao, additional, Ma, Baicheng, additional, Liu, Jianyun, additional, Li, Xingnuan, additional, Xiong, Jianjun, additional, Hua, Jinlian, additional, Ye, Junhua, additional, Lei, Anmin, additional, and Yang, Qianyong, additional

Published
2023
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6. A nomogram incorporating red blood cell indices to predict post-stroke cognitive impairment in the intracerebral hemorrhage population

Author

Gu, Yongzhe, Wang, Fang, Gong, Li, Fang, Min, and Liu, Xueyuan

Subjects
Aging, Cognitive Neuroscience
Abstract

BackgroundPost-stroke cognitive impairment (PSCI) plagues 20–80% of stroke survivors worldwide. There is a lack of an easy and effective scoring tool to predict the risk of PSCI in intracerebral hemorrhage (ICH) patients. We aimed to develop a risk prediction model incorporating red blood cell (RBC) indices to identify ICH populations at risk of PSCI.MethodsPatients diagnosed with ICH at the stroke center were consecutively enrolled in the study as part of the development cohort from July 2017 to December 2018, and of the validation cohort from July 2019 to February 2020. Univariable and multivariable analyses were applied in the development cohort to screen the patients for PSCI risk factors. Then, a nomogram based on RBC indices and other risk factors was developed and validated to evaluate its performance in predicting PSCI occurrence.ResultsA total of 123 patients were enrolled in the development cohort, of which 69 (56.1%) were identified as PSCI, while 38 (63.3%) of 60 patients in the validation cohort were identified as PSCI. According to the multivariate analysis, seven independent risk factors, including three RBC indices (hemoglobin, mean corpuscular volume, RBC distribution width), as well as age, education level, hematoma volume, and dominant-hemisphere hemorrhage were incorporated into the model. The nomogram incorporating RBC indices displayed good discrimination and calibration. The area under the receiver operating characteristic curve was 0.940 for the development cohort and 0.914 for the validation cohort. Decision curve analysis and clinical impact curve showed that the nomogram was clinically useful.ConclusionRBC indices are independent and important predictors of PSCI. A nomogram incorporating RBC indices can be used as a reasonable and reliable graphic tool to help clinicians identify high cognition impairment-risk patients and adjust individualized therapy.

Published
2022

8. Transplantation of fecal microbiota from APP/PS1 mice and Alzheimer’s disease patients enhanced endoplasmic reticulum stress in the cerebral cortex of wild-type mice

Author

Wang, Fang, Gu, Yongzhe, Xu, Chenhaoyi, Du, Kangshuai, Zhao, Chence, Zhao, Yanxin, and Liu, Xueyuan

Subjects
Aging, Cognitive Neuroscience
Abstract

Background and purposeThe gut-brain axis is bidirectional and the imbalance of the gut microbiota usually coexists with brain diseases, including Alzheimer’s disease (AD). Accumulating evidence indicates that endoplasmic reticulum (ER) stress is a core lesion in AD and persistent ER stress promotes AD pathology and impairs cognition. However, whether the imbalance of the gut microbiota is involved in triggering the ER stress in the brain remains unknown.Materials and methodsIn the present study, fecal microbiota transplantation (FMT) was performed with gut microbiota from AD patients and APP/PS1 mice, respectively, resulting in two mouse models with dysregulated gut microbiota. The ER stress marker protein levels in the cerebral cortex were assessed using western blotting. The composition of the gut microbiota was assessed using 16S rRNA sequencing.ResultsExcessive ER stress was induced in the cerebral cortex of mice after FMT. Elevated ER stress marker proteins (p-perk/perk, p-eIF2α/eIF2α) were observed, which were rescued by 3,3-dimethyl-1-butanol (DMB). Notably, DMB is a compound that significantly attenuates serum trimethylamine-N-oxide (TMAO), a metabolite of the gut microbiota widely reported to affect cognition.ConclusionThe findings indicate that imbalance of the gut microbiota induces ER stress in the cerebral cortex, which may be mediated by TMAO.

Published
2022

11. Computed Tomography Density and β-Amyloid Deposition of Intraorbital Optic Nerve May Assist in Diagnosing Mild Cognitive Impairment and Alzheimer’s Disease: A 18F-Flutemetamol Positron Emission Tomography/Computed Tomography Study

Author

Wu, Han, primary, Lei, Zhe, additional, Ou, Yinghui, additional, Shi, Xin, additional, Xu, Qian, additional, Shi, Keqing, additional, Ding, Jing, additional, Zhao, Qianhua, additional, Wang, Xiuzhe, additional, Cai, Xiaolong, additional, Liu, Xueyuan, additional, Lou, Jingjing, additional, and Liu, Xingdang, additional

Published
2022
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18. Patient and Family Caregiver's Neuroticism and Conscientiousness Personality in Relation to Quality of Life of Patient With Parkinson's Disease: A Cross-Sectional Study Neuroticism and Conscientiousness Personality in Relation to QoL of Patient With PD

Author

Ma, Xiaoye, primary, Meng, Guilin, additional, Tan, Yan, additional, Liu, Xiaohui, additional, Zhao, Yichen, additional, Yu, Jia, additional, Jin, Aiping, additional, Zhao, Yanxin, additional, and Liu, Xueyuan, additional

Published
2018
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