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Adolescence is an important period when the brain undergoes many changes. Because the brain is changing so much at this time, our experiences can have a huge impact on the brain’s health. Positive experiences keep the mind healthy, whereas negative experiences can lead to mental disorders. To process all the information that comes into the brain, the brain cells must talk with each other. They communicate via messenger systems. One of these systems is called the endocannabinoid (eCB) system. The eCB system plays an important role in the changes that happen in the adolescent brain. In this article, we see how the eCB system is affected by cannabis and how this may lead to a mental disorder.