1. Spatial memory deficit across aging: current insights of the role of 5-HT7 receptors
- Author
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Christelle Jozet-Alves, Gregory Beaudet, François Dauphin, Michel Boulouard, Thomas Freret, Valentine Bouet, Pascale Schumann-Bard, Eleni Paizanis, Groupe Mémoire et Plasticité comportementale ( GMPc ), Université de Caen Normandie ( UNICAEN ), Normandie Université ( NU ) -Normandie Université ( NU ), Groupe Mémoire et Plasticité comportementale (GMPc), Université de Caen Normandie (UNICAEN), and Normandie Université (NU)-Normandie Université (NU)
- Subjects
[ SDV.BA.ZI ] Life Sciences [q-bio]/Animal biology/Invertebrate Zoology ,[SDV]Life Sciences [q-bio] ,Cognitive Neuroscience ,double dissociation ,Hippocampal formation ,recognition memory ,in-situ hybridization ,Spatial memory ,lcsh:RC321-571 ,Mini Review Article ,Behavioral Neuroscience ,age-differences ,rat-brain ,spatial cognition ,Cognitive decline ,navigational strategies ,lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry ,Recognition memory ,[ SDV ] Life Sciences [q-bio] ,Cognitive map ,[SCCO.NEUR]Cognitive science/Neuroscience ,5-HT 7 R ,aging ,Cognition ,Spatial cognition ,Alzheimer's disease ,gene-expression ,serotonin ,Barnes maze ,[SDV.BA.ZI]Life Sciences [q-bio]/Animal biology/Invertebrate Zoology ,Neuropsychology and Physiological Psychology ,messenger-rna ,barnes maze ,[ SCCO.NEUR ] Cognitive science/Neuroscience ,caudate-nucleus ,5-ht7r ,Psychology ,Alzheimer’s disease ,Neuroscience - Abstract
WOS:000348100700001; International audience; Elderly persons often face biological, psychological or social changes over time that may cause discomfort or morbidity. While some cognitive domains remain stable over time, others undergo a decline. Spatial navigation is a complex cognitive function essential for independence, safety and quality of life. While egocentric (body centered) navigation is quite preserved during aging, allocentric (externally centered) navigation based on a cognitive map using distant landmarks declines with age. Recent preclinical studies showed that serotonergic 5-HT7 receptors are localized in brain regions associated with allocentric spatial navigation processing. Behavioral assessments with pharmacological or genetic tools have confirmed the role of 5-HT7 receptors in allocentric navigation. Moreover, few data suggested a selective age-related decrease in the expression of 5-HT7 receptors in pivotal brain structures implicated in allocentric navigation such as the hippocampal CA3 region. We aim to provide a short overview of the potential role of 5-HT7 receptors in spatial navigation, and to argue for their interests as therapeutic targets against age-related cognitive decline.
- Published
- 2015
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