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The Jurassic strata constitute a focal area for recent exploration and development of tight gas reservoirs in the western Sichuan Basin. This study investigates the Jurassic Shaximiao Formation in the northern Longmenshan in the Western Sichuan basin, focusing on tight gas reservoirs. The research integrates core and outcrop observations, seismic interpretations, and burial history analyses to understand hydrocarbon source rocks, sedimentation, reservoir characteristics, and structural characteristics. The impact of Yanshan-Himalayan tectonic movements on tight gas reservoir accumulation in the Shaximiao Formation is dissected, primarily around the Qiulin structure. The Western Sichuan Depression basin’s formation is influenced by gravitational gliding tectonics, which can be classified into the ‘Three Zones and One Belt,’ with Longmenshan in the frontal belt. Burial history analysis reveals distinct processes in the foreland belt and the depression basin. In the Qiulin area, gas reservoirs in the Shaximiao Formation are mainly charged by source rocks from the Xujiahe Formation. Tectonic movements play a significant role in creating favorable reservoirs and conditions for hydrocarbon migration and preservation. Natural gas accumulation is primarily controlled by fault connectivity to hydrocarbon sources and effective reservoir thickness. Gravitational sliding tectonics have shaped a fluvial-lacustrine environment for the Shaximiao Formation, with fluvial sand bodies acting as favorable reservoir zones. Small-scale normal faults formed by tectonic movements serve as conduits for natural gas migration. The research findings are of significant guidance for the exploration and development of tight oil and gas resources in western Sichuan basin.

Background: Patients diagnosed with influenza and upper respiratory tract infections (URTIs) have similar clinical manifestations and biochemical indices and a low detection rate of viral pathogens, mixed infection with diverse respiratory viruses, and targeted antiviral treatment difficulty in the early stage. According to the treatment strategy of “homotherapy for heteropathy” in traditional Chinese medicine (TCM), different diseases with the same clinical symptoms can be treated with the same medicines. Qingfei Dayuan granules (QFDY), a type of Chinese herbal preparation included in the TCM Diagnosis and Treatment Protocol for COVID-19 of Hubei Province issued by the Health Commission of Hubei Province in 2021, are recommended for patients suffering from COVID-19 with symptoms of fever, cough, and fatigue, among others. Additionally, recent studies have shown that QFDY effectively alleviates fever, cough, and other clinical symptoms in patients with influenza and URTIs.Materials and methods: The study was designed as a multicenter, randomized, double-blind, placebo-controlled clinical trial for treatment for influenza and URTIs manifested by pulmonary heat-toxin syndrome (PHTS) with QFDY. A total of 220 eligible patients were enrolled from eight first-class hospitals in five cities of Hubei Province in China and randomly assigned to receive either 15 g of QFDY or a placebo three times a day for 5 days. The primary outcome was the complete fever relief time. Secondary outcomes included efficacy evaluation of TCM syndromes, scores of TCM syndromes, cure rate of each single symptom, incidence of comorbidities and progression to severe conditions, combined medications, and laboratory tests. Safety evaluations mainly involved adverse events (AEs) and changes in vital signs during the study.Results: Compared with the placebo group, the complete fever relief time was shorter in the QFDY group, 24 h (12.0, 48.0) in the full analysis set (FAS) and 24 h (12.0, 49.5) in the per-protocol set (PPS) (p ≤ 0.001). After a 3-day treatment, the clinical recovery rate (22.3% in the FAS and 21.6% in the PPS) and cure rate of cough (38.6% in the FAS and 37.9% in the PPS), a stuffy and running nose, and sneezing (60.0% in the FAS and 59.5% in the PPS) in the QFDY group were higher than those in the placebo group (p < 0.05). The number of patients taking antibiotics for more than 24 h in the placebo group (nine cases) was significantly higher than that in the QFDY group (one case) (p < 0.05). There were no significant differences between the two groups in terms of scores of TCM syndromes, incidence of comorbidities or progression to severe conditions, combined use of acetaminophen tablets or phlegm-resolving medicines, and laboratory tests (p > 0.05). Meanwhile, no significant difference was found in the incidence of AEs and vital signs between the two groups (p > 0.05).Conclusion: The trial showed that QFDY was an effective and safe treatment modality for influenza and URTIs manifested by PHTS because it shortened the complete fever relief time, accelerated clinical recovery, and alleviated symptoms such as cough, a stuffy and running nose, and sneezing during the course of treatment.Clinical trial registration:https://www.chictr.org.cn/showproj.aspx?proj=131702, identifier ChiCTR2100049695.

With the development of autonomous vehicle technology, human-centered transport research will likely shift to the interaction between humans and vehicles. This study focuses on the human trust variation in autonomous vehicles (AVs) as the technology becomes increasingly intelligent. This study uses electroencephalogram data to analyze human trust in AVs during simulated driving conditions. Two driving conditions, the semi-autonomous and the autonomous, which correspond to the two highest levels of automatic driving, are used for the simulation, accompanied by various driving and car conditions. The graph theoretical analysis (GTA) is the primary method for data analysis. In semi-autonomous driving mode, the local efficiency and cluster coefficient are lower in car-normal conditions than in car-malfunction conditions with the car approaching. This finding suggests that the human brain has a strong information processing ability while facing predictable potential hazards. However, when it comes to a traffic light with a car malfunctioning under the semi-autonomous driving mode, the characteristic path length is higher for the car malfunction manifesting a weak information processing ability while facing unpredictable potential hazards. Furthermore, in fully automatic driving conditions, participants cannot do anything and need low-level brain function to take emergency actions as lower local efficiency and small worldness for car malfunction. Our results shed light on the design of the human-machine interaction and human factor engineering on the high level of an autonomous vehicle.