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Your search keyword '"Michaël Loschi"' showing total 1 results
Start Over Author "Michaël Loschi" Publisher frontiers media s.a.
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1. Effects of MicroRNA on Regulatory T Cells and Implications for Adoptive Cellular Therapy to Ameliorate Graft-versus-Host Disease

Author

Keli L. Hippen, Michael Loschi, Jemma Nicholls, Kelli P. A. MacDonald, and Bruce R. Blazar

Subjects
regulatory T cell, tTreg, iTreg, microRNA, graft-versus-host disease, Immunologic diseases. Allergy, RC581-607
Abstract

Regulatory T cells (Tregs) are key mediators of the immune system. MicroRNAs (miRNAs) are a family of ~22 nucleotide non-coding RNAs that are processed from longer precursors by the RNases Drosha and Dicer. miRNA regulates protein expression posttranscriptionally through mRNA destabilization or translational silencing. A critical role for miRNA in Treg function was initially discovered when both Dicer and Drosha knockout (KO) mice were found to develop a fatal autoimmune disease phenotypically similar to Foxp3 KO mice.

Published
2018
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