1. Total serum FGF-21 levels positively relate to visceral adiposity differently from its functional intact form
- Author
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Lucilla Crudele, Oihane Garcia-Irigoyen, Marica Cariello, Marilidia Piglionica, Natasha Scialpi, Marilina Florio, Giuseppina Piazzolla, Patrizia Suppressa, Carlo Sabbà, Raffaella Maria Gadaleta, and Antonio Moschetta
- Subjects
visceral obesity ,HDL cholesterol ,intact FGF21 ,waist circumference ,vitamin D ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
ObjectiveIncreased Fibroblast Growth Factor-21 (FGF-21) circulating levels have been described in obesity. In this observational study, we analysed a group of subjects with metabolic disorders to unravel the putative link between visceral adiposity and FGF-21 serum levels.MethodsTotal and intact serum FGF-21 concentration was measured with an ELISA assay respectively in 51 and 46 subjects, comparing FGF-21 levels in dysmetabolic conditions. We also tested Spearman’s correlations between FGF-21 serum levels and biochemical and clinical metabolic parameters.ResultsFGF-21 was not significantly increased in high-risk conditions such as visceral obesity, Metabolic Syndrome, diabetes, smoking, and atherosclerosis. Waist Circumference (WC), but not BMI, positively correlated with total FGF-21 levels (r=0.31, p
- Published
- 2023
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