1. Electrophysiological effects of adipose graft transposition procedure (AGTP) on the post-myocardial infarction scar: A multimodal characterization of arrhythmogenic substrate
- Author
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Raquel Adeliño, Daina Martínez-Falguera, Carolina Curiel, Albert Teis, Roger Marsal, Oriol Rodríguez-Leor, Cristina Prat-Vidal, Edgar Fadeuilhe, Júlia Aranyó, Elena Revuelta-López, Axel Sarrias, Víctor Bazan, Joan F. Andrés-Cordón, Santiago Roura, Roger Villuendas, Josep Lupón, Antoni Bayes-Genis, Carolina Gálvez-Montón, and Felipe Bisbal
- Subjects
myocardial infarction ,adipose graft transposition procedure ,myocardial repair ,arrhythmic risk ,ventricular tachycardia ,mapping ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
ObjectiveTo assess the arrhythmic safety profile of the adipose graft transposition procedure (AGTP) and its electrophysiological effects on post-myocardial infarction (MI) scar.BackgroundMyocardial repair is a promising treatment for patients with MI. The AGTP is a cardiac reparative therapy that reduces infarct size and improves cardiac function. The impact of AGTP on arrhythmogenesis has not been addressed.MethodsMI was induced in 20 swine. Contrast-enhanced magnetic resonance (ce-MRI), electrophysiological study (EPS), and left-ventricular endocardial high-density mapping were performed 15 days post-MI. Animals were randomized 1:1 to AGTP or sham-surgery group and monitored with ECG-Holter. Repeat EPS, endocardial mapping, and ce-MRI were performed 30 days post-intervention. Myocardial SERCA2, Connexin-43 (Cx43), Ryanodine receptor-2 (RyR2), and cardiac troponin-I (cTnI) gene and protein expression were evaluated.ResultsThe AGTP group showed a significant reduction of the total infarct scar, border zone and dense scar mass by ce-MRI (p = 0.04), and a decreased total scar and border zone area in bipolar voltage mapping (p < 0.001). AGTP treatment significantly reduced the area of very-slow conduction velocity (
- Published
- 2022
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