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In the northern Da Xing’anling Mountains in Northeast China on the southern margin of the Eastern Asia permafrost body, the ground thermal state and boreal ecological environment are sensitive to climate change and human activities. Since the 1980s, the Hola Basin here has been continuously and extensively developed. In particular, open pits and later backfilling in strip coal mining alters land–atmospheric hydrothermal exchanges in permafrost regions, leading to serious damages to the permafrost environment and boreal forest. After mining, pits need to be backfilled timely and properly for hydrothermal recovery of Xing’an permafrost and the boreal ecological environment. In this study, based on the comparative analysis of monitored ground temperatures in backfilled and undisturbed areas, influencing factors of thermal recovery after backfilling were analyzed through numerical simulations. Results show that the thermal recovery of permafrost in the backfilled area is closely related to temperature, depth, material, and soil moisture content of backfill. The warmer, finer, and thicker the backfill soils, the longer the permafrost recovery. Thermal recovery of permafrost also depends on the moisture content of backfill; the shortest recovery occurs at 15–25% in the backfilled soil moisture content. Based on numerical simulations and combined with enlightenments from features of the ecosystem-protected Xing’an permafrost in Northeast China, a composite configuration of organic soil, crush-rock layer, and proper re-vegetation measures is advised. Based on prudent regulation of heat transfer modes, this composite backfilling method can effectively cool the backfilled ground and can even possibly offset the climate warming.

Cancer-induced bone pain (CIBP) has a considerable impact on patients’ quality of life as well as physical and mental health. At present, patients with CIBP are managed according to the three-step analgesic therapy algorithm proposed by the World Health Organization. Opioids are commonly used as the first-line treatment for moderate-to-severe cancer pain but are limited due to addiction, nausea, vomiting and other gastrointestinal side effects. Moreover, opioids have a limited analgesic effect in some patients. In order to optimize the management of CIBP, we must first identify the underlying mechanisms. In some patients, surgery, or surgery combined with radiotherapy or radiofrequency ablation is the first step in the management of CIBP. Various clinical studies have shown that anti-nerve growth factor (NGF) antibodies, bisphosphonates, or RANKL inhibitors can reduce the incidence and improve the management of cancer pain. Herein, we review the mechanisms of cancer pain and potential therapeutic strategies to provide insights for optimizing the management of CIBP.

Osteosarcoma is the most common bone tumor affecting both adolescents and children. Although localized osteosarcoma has an overall survival of >70% in the clinic, metastatic, refractory, and recurrent osteosarcoma have poorer survival rates. Exosomes are extracellular vesicles released by cells and originally thought to be a way for cells to discard unwanted products. Currently, exosomes have been reported to be involved in intercellular cross-talk and induce changes in cellular behavior by transferring cargoes (proteins, DNA, RNA, and lipids) between cells. Exosomes regulate osteosarcoma progression, and processes such as tumorigenesis, proliferation, metastasis, angiogenesis, immune evasion, and drug resistance. Increasing evidences shows that exosomes have significant potential in promoting osteosarcoma progression and development. In this review, we describe the current research status of exosomes in osteosarcoma, focusing on the biological functions of osteosarcoma exosomes as well as their application in osteosarcoma as diagnostic biomarkers and therapeutic targets.