1. Active tuberculosis patients have high systemic IgG levels and B-cell fingerprinting, characterized by a reduced capacity to produce IFN-γ or IL-10 as a response to M.tb antigens.
- Author
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Flores-Gonzalez, Julio, Urbán-Solano, Alexia, Ramón-Luing, Lucero A., Carlos Cancino-Diaz, Juan, Contreras-Rodriguez, Araceli, Curiel-Quesada, Everardo, Hernández-Pando, Rogelio, and Chavez-Galan, Leslie
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TUBERCULOSIS patients ,B cells ,INTERLEUKIN-10 ,HUMORAL immunity ,MYCOBACTERIUM tuberculosis - Abstract
Introduction: Tuberculosis (TB) is a bacterial infection caused by Mycobacterium tuberculosis (M.tb). B cells are the central mediator of the humoral response; they are responsible for producing antibodies in addition to mediating other functions. The role of the cellular response during the TB spectrum by B cells is still controversial. Methods: In this study, we evaluated the distribution of the circulating B cell subsets in patients with active and latent TB (ATB and LTB, respectively) and how they respond to stimuli of protein or lipid from M.tb. Results: Here, we show that ATB patients show an immune fingerprinting. However, patients with drug-sensitive- (DS-TB) or drug-resistant- (DR-TB) TB have altered frequencies of circulating B cells. DS-TB and DR-TB display a unique profile characterized by high systemic levels of IFN-γ, IL-10, IgG, IgG/IgM ratio, and total B cells. Moreover, B cells from DR-TB are less efficient in producing IL-10, and both DS-TB and DR-TB produce less IFN-γ in response to M.tb antigens. Conclusion: These results provide new insights into the population dynamics of the cellular immune response by B cells against M. tb and suggest a fingerprinting to characterize the B-cell response on DR-TB. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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