Search

Background: Idiopathic pulmonary fibrosis (IPF) is characterized by a male predominance. The aim of the study was to explore gender differences in a well-designed French multicentre prospective IPF cohort (COhorte FIbrose, COFI) with a 5-year follow-up. Methods: Between 2007 and 2010, 236 patients with incident IPF were included in COFI. Gender characteristics were compared using a t -test, Chi-squared test and ANOVA, as appropriate. Survival analyses were performed. Results: Fifty-one (22%) females and 185 (78%) males with an average age at diagnosis of 70.1 ± 9.20 and 67.4 ± 10.9 years, respectively, were included in the cohort. Women were significantly less exposed to tobacco smoke [never n = 32 (62.7%) vs. n = 39 (21.1%), p < 0.001] and to occupational exposure [ n = 7 (13.7%) vs. n = 63 (34.1%), p = 0.012]. Baseline forced vital capacity, % of predicted (FVC%) was significantly better in women compare to men (83.0% ± 25.0 v. 75.4% ± 18.7 p = 0.046). At presentation honeycombing and emphysema on CT scan were less common in women [ n = 40 (78.4%) vs. n = 167 (90.3%) p = 0.041] and [ n = 6 (11.8%) vs. n = 48 (25.9%) p = 0.029], respectively. During follow-up fewer women were transplanted compared to men [ n = 1 (1.96%) vs. n = 20 (10.8%) p = 0.039]. Medians of survival were comparable by gender [31 months (CI 95%: 28-40) vs. 40 months (CI 95%: 33-72) p = 0.2]. After adjusting for age and FVC at inclusion, being a woman was not associated to a better survival. Conclusions: Women appear to have less advanced disease at diagnosis, maybe due to less exposure history compare to men. Disease progression and overall survival remains comparable regardless gender, but women have less access to lung transplantation., Competing Interests: LS reports personal fees and non-financial support from Roche/Genentech, non-financial support from Boehringer Ingelheim, personal fees from Boehringer Ingelheim, outside the submitted work. HN reports grants and personal fees from Roche/Genentech, Boehringer Ingelheim, personal fees from Galapagos, other from Sanofi, Gilead, Novartis, Galecto Biotech AB, during the conduct of the study; personal fees from Actelion Pharmaceuticals, outside the submitted work. VC reports personal fees and non-financial support from Actelion, grants, personal fees and non-financial support from Boehringer Ingelheim, personal fees from Bayer/MSD, Novartis, personal fees and non-financial support from Roche/Promedior, personal fees from Sanofi, Celgene, Galapagos, Galecto, Shionogi, Astra Zeneca, Fibrogen, outside the submitted work. BC reports personal fees from Astra Zeneca, grants, personal fees and non-financial support from Boehringer Ingelheim, BMS, personal fees from Sanofi, grants, personal fees and non-financial support from Roche, outside the submitted work. AT reports personal fees from Chiesi, other from VitAlaire, Astrazeneca, Boehringer Ingelheim, outside the submitted work. SM-A reports other from roche, other from Boehringer Ingelheim, outside the submitted work. SH reports personal fees from Roche, Boerhinger ingelheim, grants from CSL Behring, outside the submitted work. SD reports personal fees from Boehringer-Ingelheim, Chiesi, Roche, outside the submitted work. PB reports personal fees and other from Roche, Boehringer, Novartis, personal fees from TEVA, other from Chiesi, personal fees from AstraZeneca, other from Stallergene, outside the submitted work. RB reports grants and personal fees from Roche, Boerhinger Ingelheim, personal fees from Savara, outside the submitted work. CP reports personal fees from ROCHE, outside the submitted work. DV reports personal fees from Roche, Boehringer Ingelheim, Roche & BI, outside the submitted work. YU reports personal fees and non-financial support from Boehringer, Roche, grants, personal fees and non-financial support from Oxyvie, outside the submitted work. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2021 Sesé, Nunes, Cottin, Israel-Biet, Crestani, Guillot-Dudoret, Cadranel, Wallaert, Tazi, Maître, Prévot, Marchand-Adam, Hirschi, Dury, Giraud, Gondouin, Bonniaud, Traclet, Juvin, Borie, Carton, Freynet, Gille, Planès, Valeyre and Uzunhan.)